Details
Stereochemistry | ACHIRAL |
Molecular Formula | C15H10O8 |
Molecular Weight | 318.2357 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
c1cc(c(cc1-c2c(c(=O)c3c(cc(c(c3o2)O)O)O)O)O)O
InChI
InChIKey=YRRAGUMVDQQZIY-UHFFFAOYSA-N
InChI=1S/C15H10O8/c16-6-2-1-5(3-7(6)17)14-13(22)12(21)10-8(18)4-9(19)11(20)15(10)23-14/h1-4,16-20,22H
Molecular Formula | C15H10O8 |
Molecular Weight | 318.2357 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
DescriptionSources: https://goo.gl/xk8dNSCurator's Comment:: The description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/28671312 | https://www.ncbi.nlm.nih.gov/pubmed/25994373
Sources: https://goo.gl/xk8dNS
Curator's Comment:: The description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/28671312 | https://www.ncbi.nlm.nih.gov/pubmed/25994373
Gossypetin (3,5,7,8,3',4'-hexahydroxyflavone) is a flavonoid which has anti-mutagenic, anti-atherosclerotic, antioxidant, as well as cytoprotective and antimicrobial effects. Gossypetin is usually extracted from the flowers of the hibiscus species. Gossypetin has antiproliferative effects on breast cancer (MCF-7) and hepatocellular cancer (HepG2) cell lines. Gossypetin could protect cells against both radiation induced oxidative stress and radiation induced cellular damage via decreasing reactive oxygen species (ROSs).
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL6135 Sources: https://www.ncbi.nlm.nih.gov/pubmed/19729316 |
2.6 µM [IC50] | ||
Target ID: CHEMBL1978 Sources: https://www.ncbi.nlm.nih.gov/pubmed/18778944 |
11.0 µM [IC50] |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Sources: https://goo.gl/xk8dNS |
Primary | Unknown Approved UseUnknown |
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Primary | Unknown Approved UseUnknown |
PubMed
Title | Date | PubMed |
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New erythroxane-type diterpenoids from Fagonia boveana (Hadidi) Hadidi & Graf. | 2003 Jan-Feb |
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Electrospray mass spectrometric decomposition of some glucuronic acid-containing flavonoid diglycosides. | 2003 May-Jun |
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Women's health among the Chumash. | 2006 Mar |
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Dietary flavones and flavonoles are inhibitors of poly(ADP-ribose)polymerase-1 in pulmonary epithelial cells. | 2007 Oct |
|
Metabolic profiling of flavonoids in Lotus japonicus using liquid chromatography Fourier transform ion cyclotron resonance mass spectrometry. | 2008 Jan |
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Screening of herbal constituents for aromatase inhibitory activity. | 2008 Sep 15 |
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A cellular model to monitor proteasome dysfunction by alpha-synuclein. | 2009 Aug 25 |
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MS/MS spectral tag-based annotation of non-targeted profile of plant secondary metabolites. | 2009 Feb |
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Characterization of inhibitor-bound alpha-synuclein dimer: role of alpha-synuclein N-terminal region in dimerization and inhibitor binding. | 2010 Jan 22 |
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Anti-atherosclerotic potential of gossypetin via inhibiting LDL oxidation and foam cell formation. | 2013 Oct 15 |
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In Vitro and in Vivo Atheroprotective Effects of Gossypetin against Endothelial Cell Injury by Induction of Autophagy. | 2015 Feb 16 |
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/25622137
New Zealand white male rabbits were treated with 10 mg/kg gossypetin of 10 weeks
Route of Administration:
Oral
In Vitro Use Guide
Sources: https://goo.gl/xk8dNS
A cell viability test of GP (Gossypetin) was performed on cultured human lymphocytes to detect the maximal non-toxic concentration according to the manufacturer’s protocol. A total of 1 × 10^4 cells were seeded on each well of a 96-well plate and cultured for 24 hours. The cells were treated with different concentrations of CP (1mM), GP (25, 50 and 100 µM) and CP+GP (25, 50 and 100 µM) combinations in a serum-free medium for 24 and 48 hours. Gossypetin concentrations were selected according to previous studies. At the end of the incubation process/time, the medium containing compound was exchanged with a fresh RPMI1640 medium, and 10 μL of the reconstitute MTT mixture kit reagent were added to each well. After culturing for 4 hours, the absorbance of the sample was measured by using a microtiter plate reader (Bio-TEK) at 590 nm.
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Jun 25 23:16:18 UTC 2021
by
admin
on
Fri Jun 25 23:16:18 UTC 2021
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Record UNII |
SET4M23ZTM
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Record Status |
Validated (UNII)
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Record Version |
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GOSSYPETIN
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SET4M23ZTM
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5280647
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489-35-0
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489-35-0
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