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Details

Stereochemistry RACEMIC
Molecular Formula C16H15NO4
Molecular Weight 285.2946
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ANIROLAC

SMILES

COC1=CC=C(C=C1)C(=O)C2=CC=C3C(CCN23)C(O)=O

InChI

InChIKey=HEOZYYOUKGGSBJ-UHFFFAOYSA-N
InChI=1S/C16H15NO4/c1-21-11-4-2-10(3-5-11)15(18)14-7-6-13-12(16(19)20)8-9-17(13)14/h2-7,12H,8-9H2,1H3,(H,19,20)

HIDE SMILES / InChI

Molecular Formula C16H15NO4
Molecular Weight 285.2946
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Anirolac is a nonsteroidal anti-inflammatory drug. It is chemically related to ketorolac, and to tolmetin and indomethacin, approved nonsteroidal anti-inflammatory drugs marketed as antiarthritics but not as analgesics. Anirolac has shown both analgesic and anti-inflammatory actions in animal models. Anirolac is absorbed rapidly and completely after oral intake and has a plasma elimination half-life of about 2 hours in humans with normal renal function. Anirolac is a cyclooxygenase inhibitor and also inhibits platelet aggregation in vitro. Drowsiness is the most common side effect associated with anirolac. The pain relief provided by oral anirolac was slower to take effect, safe, and lasted longer than that provided by injectable morphine sulfate. It potentiated the GABA-antagonistic effects of the quinolones (norfloxacin, ciprofloxacin, enoxacin, and pipemidic acid).

Approval Year

Sample Use Guides

Single doses - 50 or 100 mg
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Sat Dec 16 16:35:37 GMT 2023
Edited
by admin
on Sat Dec 16 16:35:37 GMT 2023
Record UNII
S9B9E35WUX
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ANIROLAC
INN   MART.   USAN  
INN   USAN  
Official Name English
anirolac [INN]
Common Name English
ANIROLAC [USAN]
Common Name English
RS-37326
Code English
ANIROLAC [MART.]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C257
Created by admin on Sat Dec 16 16:35:37 GMT 2023 , Edited by admin on Sat Dec 16 16:35:37 GMT 2023
Code System Code Type Description
INN
5661
Created by admin on Sat Dec 16 16:35:37 GMT 2023 , Edited by admin on Sat Dec 16 16:35:37 GMT 2023
PRIMARY
NCI_THESAURUS
C80536
Created by admin on Sat Dec 16 16:35:37 GMT 2023 , Edited by admin on Sat Dec 16 16:35:37 GMT 2023
PRIMARY
FDA UNII
S9B9E35WUX
Created by admin on Sat Dec 16 16:35:37 GMT 2023 , Edited by admin on Sat Dec 16 16:35:37 GMT 2023
PRIMARY
EPA CompTox
DTXSID80867239
Created by admin on Sat Dec 16 16:35:37 GMT 2023 , Edited by admin on Sat Dec 16 16:35:37 GMT 2023
PRIMARY
MESH
C053023
Created by admin on Sat Dec 16 16:35:37 GMT 2023 , Edited by admin on Sat Dec 16 16:35:37 GMT 2023
PRIMARY
USAN
T-119
Created by admin on Sat Dec 16 16:35:37 GMT 2023 , Edited by admin on Sat Dec 16 16:35:37 GMT 2023
PRIMARY
PUBCHEM
47975
Created by admin on Sat Dec 16 16:35:37 GMT 2023 , Edited by admin on Sat Dec 16 16:35:37 GMT 2023
PRIMARY
ChEMBL
CHEMBL428479
Created by admin on Sat Dec 16 16:35:37 GMT 2023 , Edited by admin on Sat Dec 16 16:35:37 GMT 2023
PRIMARY
CAS
66635-85-6
Created by admin on Sat Dec 16 16:35:37 GMT 2023 , Edited by admin on Sat Dec 16 16:35:37 GMT 2023
PRIMARY
EVMPD
SUB05518MIG
Created by admin on Sat Dec 16 16:35:37 GMT 2023 , Edited by admin on Sat Dec 16 16:35:37 GMT 2023
PRIMARY
SMS_ID
100000086947
Created by admin on Sat Dec 16 16:35:37 GMT 2023 , Edited by admin on Sat Dec 16 16:35:37 GMT 2023
PRIMARY
Related Record Type Details
ENANTIOMER -> RACEMATE
ENANTIOMER -> RACEMATE
Related Record Type Details
ACTIVE MOIETY