CAY-10505

Details

Stereochemistry	ACHIRAL
Molecular Formula	C14H8FNO3S
Molecular Weight	289.282
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

FC1=CC=C(C=C1)C2=CC=C(O2)\C=C3\SC(=O)NC3=O

InChI

InChIKey=UFBTYTGRUBUUIL-KPKJPENVSA-N

InChI=1S/C14H8FNO3S/c15-9-3-1-8(2-4-9)11-6-5-10(19-11)7-12-13(17)16-14(18)20-12/h1-7H,(H,16,17,18)/b12-7+

HIDE SMILES / InChI

Molecular Formula	C14H8FNO3S
Molecular Weight	289.282
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 6 Target ID: P48736 Gene ID: 5294.0 Gene Symbol: PIK3CG Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/16789742	Inhibitor 8504		30.0 nM [IC50]

PubMed

Title	Date	PubMed
PI3K-dependent multiple myeloma cell survival is mediated by the PIK3CA isoform.	2014-08	24766330
Effect of phosphatidylinositol 3-kinase-γ inhibitor CAY10505 in hypertension, and its associated vascular endothelium dysfunction in rats.	2012-07	22731503

Substance Class	Chemical Created by `admin` on `Wed Apr 02 13:17:05 GMT 2025` Edited by `admin` on `Wed Apr 02 13:17:05 GMT 2025`
Record UNII	S8TQU87RAT
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CAY-10505

Code

English

CAY10505

Preferred Name

English

2,4-THIAZOLIDINEDIONE, 5-((5-(4-FLUOROPHENYL)-2-FURANYL)METHYLENE)-, (5E)-

Systematic Name

English

Code System Code Type Description

FDA UNII

S8TQU87RAT

Created by admin on Wed Apr 02 13:17:05 GMT 2025 , Edited by admin on Wed Apr 02 13:17:05 GMT 2025

PRIMARY

PUBCHEM

1204893

Created by admin on Wed Apr 02 13:17:05 GMT 2025 , Edited by admin on Wed Apr 02 13:17:05 GMT 2025

PRIMARY

CAS

1218777-13-9

Created by admin on Wed Apr 02 13:17:05 GMT 2025 , Edited by admin on Wed Apr 02 13:17:05 GMT 2025

PRIMARY

EPA CompTox

DTXSID60360955

Created by admin on Wed Apr 02 13:17:05 GMT 2025 , Edited by admin on Wed Apr 02 13:17:05 GMT 2025

PRIMARY

Related Record Type Details


					1C47E5QIN2

PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM

TARGET -> INHIBITOR

Comments:

Better than the ?, ?, and ? isoforms (IC50 = 0.94, 20, and 20 ?M, respectively).

Qualification:

IC50

Amount:

Related Record Type Details


					S8TQU87RAT

CAY-10505

ACTIVE MOIETY

Qualification:

IC50

Amount: