Etripamil

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C27H36N2O4
Molecular Weight	452.5857
Optical Activity	( - )
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC(=O)C1=CC=CC(CCN(C)CCC[C@](C#N)(C(C)C)C2=CC(OC)=C(OC)C=C2)=C1

InChI

InChIKey=VAZNEHLGJGSQEL-MHZLTWQESA-N

InChI=1S/C27H36N2O4/c1-20(2)27(19-28,23-11-12-24(31-4)25(18-23)32-5)14-8-15-29(3)16-13-21-9-7-10-22(17-21)26(30)33-6/h7,9-12,17-18,20H,8,13-16H2,1-6H3/t27-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C27H36N2O4
Molecular Weight	452.5857
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.milestonepharma.com/research-development/etripamil/

Etripamil is a non-dihydropyridine, L-type calcium channel blocker. Currently, etripamil is in Phase 3 development for the treatment of paroxysmal supraventricular tachycardia. Milestone Pharmaceuticals is also developing etripamil to provide rapid heartbeat control for patients living with atrial fibrillation and acute symptom relief for patients with angina.

Originator

Approval Year

PubMed

Title	Date	PubMed
High-density mapping of the slow pathway in a patient with atrioventricular nodal reentry given intranasal Etripamil during the NODE-1 study.	2017 Oct	29062702
Etripamil Nasal Spray for Rapid Conversion of Supraventricular Tachycardia to Sinus Rhythm.	2018 Jul 31	30049309

Sample Use Guides

In Vivo Use Guide

Phase II study: Etripamil via 4 intranasal applications (140 mg, 105 mg, 70 mg, or 35 mg)

Route of Administration: Nasal

Substance Class	Chemical Created by `admin` on `Sat Dec 16 09:40:05 GMT 2023` Edited by `admin` on `Sat Dec 16 09:40:05 GMT 2023`
Record UNII	S82A18Y42P
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Etripamil

Official Name

English

MSP-2017

Code

English

Methyl 3-[2-[[(4S)-4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl]methylamino]ethyl]benzoate

Systematic Name

English

ETRIPAMIL [USAN]

Common Name

English

Benzoic acid, 3-[2-[[(4S)-4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl]methylamino]ethyl]-, methyl ester

Systematic Name

English

Etripamil [WHO-DD]

Common Name

English

etripamil [INN]

Common Name

English

(-)-MSP-2017

Code

English

Code System Code Type Description

FDA UNII

S82A18Y42P