7-CHLOROKYNURENIC ACID

OC(=O)C1=NC2=C(C=CC(Cl)=C2)C(O)=C1

InChIKey=UAWVRVFHMOSAPU-UHFFFAOYSA-N

InChI=1S/C10H6ClNO3/c11-5-1-2-6-7(3-5)12-8(10(14)15)4-9(6)13/h1-4H,(H,12,13)(H,14,15)

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Targets

Primary Target	Pharmacology	Condition	Potency
Glutamate NMDA receptor; Grin1/Grin2c 5 Target ID: CHEMBL2096911 Sources: https://www.ncbi.nlm.nih.gov/pubmed/2842779	Antagonist 2849		0.56 µM [IC50]

PubMed

Title	Date	PubMed
Role for D-serine within the ventral tegmental area in the development of cocaine's sensitization.	2008-04	17609678
Prevention of cocaine-induced convulsions and lethality in mice: effectiveness of targeting different sites on the NMDA receptor complex.	2000-01-28	10698007
Anticonvulsant efficacy of N-methyl-D-aspartate antagonists against convulsions induced by cocaine.	1999-05	10215643
Some central effects of kynurenic acid, 7-chlorokynurenic acid and 5,7- dichloro-kynurenic acid, glycine site antagonists.	1994-05-01	8000442
Glycine site antagonists abolish dopamine D2 but not D1 receptor mediated catalepsy in rats.	1994	7865167

Substance Class	Chemical Created by `admin` on `Mon Mar 31 19:07:08 GMT 2025` Edited by `admin` on `Mon Mar 31 19:07:08 GMT 2025`
Record UNII	S7936QON2K
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

7-CHLOROKYNURENIC ACID

Common Name

English

NSC-149792

Preferred Name

English

2-QUINOLINECARBOXYLIC ACID, 7-CHLORO-4-HYDROXY-

Systematic Name

English

KYNURENIC ACID, 7-CHLORO-

Common Name

English

Code System Code Type Description

CAS

18000-24-3