7-CHLOROKYNURENIC ACID

OC(=O)C1=NC2=CC(Cl)=CC=C2C(O)=C1

InChIKey=UAWVRVFHMOSAPU-UHFFFAOYSA-N

InChI=1S/C10H6ClNO3/c11-5-1-2-6-7(3-5)12-8(10(14)15)4-9(6)13/h1-4H,(H,12,13)(H,14,15)

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Targets

Primary Target	Pharmacology	Condition	Potency
Glutamate NMDA receptor; Grin1/Grin2c 4 Target ID: CHEMBL2096911 Sources: https://www.ncbi.nlm.nih.gov/pubmed/2842779	Antagonist 2778		0.56 µM [IC50]

PubMed

Title	Date	PubMed
Glycine site antagonists abolish dopamine D2 but not D1 receptor mediated catalepsy in rats.	1994	7865167
Some central effects of kynurenic acid, 7-chlorokynurenic acid and 5,7- dichloro-kynurenic acid, glycine site antagonists.	1994 May-Jun	8000442
Anticonvulsant efficacy of N-methyl-D-aspartate antagonists against convulsions induced by cocaine.	1999 May	10215643
Prevention of cocaine-induced convulsions and lethality in mice: effectiveness of targeting different sites on the NMDA receptor complex.	2000 Jan 28	10698007
Role for D-serine within the ventral tegmental area in the development of cocaine's sensitization.	2008 Apr	17609678

Substance Class	Chemical Created by `admin` on `Fri Dec 15 18:11:08 GMT 2023` Edited by `admin` on `Fri Dec 15 18:11:08 GMT 2023`
Record UNII	S7936QON2K
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

7-CHLOROKYNURENIC ACID

Common Name

English

2-QUINOLINECARBOXYLIC ACID, 7-CHLORO-4-HYDROXY-

Systematic Name

English

KYNURENIC ACID, 7-CHLORO-

Common Name

English

NSC-149792

Code

English

Code System Code Type Description

CAS

18000-24-3