FEBANTEL

Details

Stereochemistry	ACHIRAL
Molecular Formula	C20H22N4O6S
Molecular Weight	446.477
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COCC(=O)NC1=CC(SC2=CC=CC=C2)=CC=C1N=C(NC(=O)OC)NC(=O)OC

InChI

InChIKey=HMCCXLBXIJMERM-UHFFFAOYSA-N

InChI=1S/C20H22N4O6S/c1-28-12-17(25)21-16-11-14(31-13-7-5-4-6-8-13)9-10-15(16)22-18(23-19(26)29-2)24-20(27)30-3/h4-11H,12H2,1-3H3,(H,21,25)(H2,22,23,24,26,27)

HIDE SMILES / InChI

Molecular Formula	C20H22N4O6S
Molecular Weight	446.477
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.inchem.org/documents/jecfa/jecmono/v29je03.htm

Febantel is a anthelminthic agent used for the treatment of parasitic worms in animals.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Tapeworms, Hookworms, Ascarids and Whipworms infection 1 Sources: http://www.fda.gov/downloads/AnimalVeterinary/Products/ApprovedAnimalDrugProducts/FOIADrugSummaries/ucm116081.pdf	Curative		Approved 8583	DRONTAL Approved Use DRONTAL Plus (praziquantel/pyrantel pamoate/febantel) TASTE TABS Broad Spectrum Chewable Anthelmintic Tablets are indicated for the removal of Tapeworms (Dipylidium caninum, Taenia pisiformis, Echinococcus granulosus, and removal and control of Echinococcus multilocularis) and for removal of Hookworms (Ancylostoma caninum, Uncinaria stenocephala), Ascarids (Toxocara canis, Toxascaris leonina) and Whipworms (Trichuris vulpis) in dogs. Launch Date 2006

PubMed

Title	Date	PubMed
Synergistic effect of febantel and pyrantel embonate in elimination of Giardia in a gerbil model.	2009-08	19575234
Treatment of naturally occurring, asymptomatic Giardia sp. in dogs with Drontal Plus flavour tablets.	2009-08	19575233
Efficacy of Drontal Flavour Plus (50 mg praziquantel, 144 mg pyrantel embonate, 150 mg febantel per tablet) against Giardia sp in naturally infected dogs.	2008-10	18661153

Patents

Sample Use Guides

In Vivo Use Guide

Weight 0.9 to 1.8 kg (2 to 4 pounds): Dose is one-half tablet No.1 (22.7 milligrams praziquantel, 22.7 milligrams pyrantel base, and 113.4 milligrams febantel); Weight 2.3 to 3.2 kg (5 to 7 pounds): Dose is one tablet No.1; Weight 3.6 to 5.4 kg (8 to 12 pounds): Dose is one and one-half tablet No.1; Weight 5.9 to 8.2 kg (13 to 18 pounds): Dose is two tablets No.1; Weight 8.6 to 11.4 kg (19 to 25 pounds): Dose is two and one-half tablets No.1; Weight 11.8 to 13.6 kg (26 to 30 pounds): Dose is one tablet No.2 (68 milligrams praziquantel, 68 milligrams pyrantel base, and 340.2 milligrams febantel); Weight 14.1 to 20.0 kg (31 to 44 pounds): Dose is one and one-half tablets No.2; Weight 20.4 to 27.2 kg (45 to 60 pounds): Dose is two tablet No.2 and one tablet No. 3 (136 milligrams praziquantel, 136 milligrams pyrantel base, and 680.4 milligrams febantel); Weight 27.7 to 40.9 kg (61 to 90 pounds): Dose is one and one-half tablets No. 3; Weight 41.3 to 54.5 kg (91 to 120 pounds): Dose is two tablets No. 3.

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:14:14 GMT 2025` Edited by `admin` on `Mon Mar 31 18:14:14 GMT 2025`
Record UNII	S75C401OS1
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

FEBANTEL

Official Name

English

FEBANTEL FOR VETERINARY USE

Preferred Name

English

Dimethyl [[2-(2-methoxyacetamido)-4-(phenylthio)phenyl]imidocarbonyl]dicarbamate

Systematic Name

English

BAY VH 5757

Code

English

BAY H 5757

Code

English

FEBANTEL [USAN]

Common Name

English

febantel [INN]

Common Name

English

FEBANTEL [MART.]

Common Name

English

BAY-VH-5757

Code

English

ORATEL

Code

English

FEBANTEL [GREEN BOOK]

Common Name

English

FEBANTEL FOR VETERINARY USE [EP MONOGRAPH]

Common Name

English

FEBANTEL [USP-RS]

Common Name

English

NEGABOT PLUS PASTE

Code

English

RINTAL

Code

English

FEBANTEL [MI]

Common Name

English

CARBAMIC ACID, ((2-((METHOXYACETYL)AMINO)-4-(PHENYLTHIO)PHENYL)CARBONIMIDOYL)BIS-, DIMETHYL ESTER

Systematic Name

English

BAYH-5757

Code

English

BAYVH-5757

Code

English

COMBOTEL

Code

English

BAY-H-5757

Code

English

Classification Tree Code System Code

CFR

21 CFR 520.903D