U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C20H22N4O6S
Molecular Weight 446.477
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of FEBANTEL

SMILES

COCC(=O)NC1=CC(SC2=CC=CC=C2)=CC=C1N=C(NC(=O)OC)NC(=O)OC

InChI

InChIKey=HMCCXLBXIJMERM-UHFFFAOYSA-N
InChI=1S/C20H22N4O6S/c1-28-12-17(25)21-16-11-14(31-13-7-5-4-6-8-13)9-10-15(16)22-18(23-19(26)29-2)24-20(27)30-3/h4-11H,12H2,1-3H3,(H,21,25)(H2,22,23,24,26,27)

HIDE SMILES / InChI
Molecular Formula C20H22N4O6S
Molecular Weight 446.477
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Febantel is a anthelminthic agent used for the treatment of parasitic worms in animals.

Approval Year

1994
149
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
Approved
8429
DRONTAL

Approved Use

DRONTAL Plus (praziquantel/pyrantel pamoate/febantel) TASTE TABS Broad Spectrum Chewable Anthelmintic Tablets are indicated for the removal of Tapeworms (Dipylidium caninum, Taenia pisiformis, Echinococcus granulosus, and removal and control of Echinococcus multilocularis) and for removal of Hookworms (Ancylostoma caninum, Uncinaria stenocephala), Ascarids (Toxocara canis, Toxascaris leonina) and Whipworms (Trichuris vulpis) in dogs.

Launch Date

2006
PubMed

PubMed

TitleDatePubMed
Efficacy of Drontal Flavour Plus (50 mg praziquantel, 144 mg pyrantel embonate, 150 mg febantel per tablet) against Giardia sp in naturally infected dogs.
2008 Oct
Synergistic effect of febantel and pyrantel embonate in elimination of Giardia in a gerbil model.
2009 Aug
Treatment of naturally occurring, asymptomatic Giardia sp. in dogs with Drontal Plus flavour tablets.
2009 Aug
Patents

Patents

CN101412689 A
1

Sample Use Guides

In Vivo Use Guide
Weight 0.9 to 1.8 kg (2 to 4 pounds): Dose is one-half tablet No.1 (22.7 milligrams praziquantel, 22.7 milligrams pyrantel base, and 113.4 milligrams febantel); Weight 2.3 to 3.2 kg (5 to 7 pounds): Dose is one tablet No.1; Weight 3.6 to 5.4 kg (8 to 12 pounds): Dose is one and one-half tablet No.1; Weight 5.9 to 8.2 kg (13 to 18 pounds): Dose is two tablets No.1; Weight 8.6 to 11.4 kg (19 to 25 pounds): Dose is two and one-half tablets No.1; Weight 11.8 to 13.6 kg (26 to 30 pounds): Dose is one tablet No.2 (68 milligrams praziquantel, 68 milligrams pyrantel base, and 340.2 milligrams febantel); Weight 14.1 to 20.0 kg (31 to 44 pounds): Dose is one and one-half tablets No.2; Weight 20.4 to 27.2 kg (45 to 60 pounds): Dose is two tablet No.2 and one tablet No. 3 (136 milligrams praziquantel, 136 milligrams pyrantel base, and 680.4 milligrams febantel); Weight 27.7 to 40.9 kg (61 to 90 pounds): Dose is one and one-half tablets No. 3; Weight 41.3 to 54.5 kg (91 to 120 pounds): Dose is two tablets No. 3.
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:56:56 GMT 2023
Edited
by admin
on Fri Dec 15 15:56:56 GMT 2023
Record UNII
S75C401OS1
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
FEBANTEL
GREEN BOOK   INN   MART.   MI   USAN  
INN   USAN  
Official Name English
Dimethyl [[2-(2-methoxyacetamido)-4-(phenylthio)phenyl]imidocarbonyl]dicarbamate
Systematic Name English
BAY VH 5757
Code English
BAY H 5757
Code English
FEBANTEL [USAN]
Common Name English
febantel [INN]
Common Name English
FEBANTEL [MART.]
Common Name English
BAY-VH-5757
Code English
ORATEL
Code English
FEBANTEL [GREEN BOOK]
Common Name English
FEBANTEL FOR VETERINARY USE [EP MONOGRAPH]
Common Name English
FEBANTEL [USP-RS]
Common Name English
NEGABOT PLUS PASTE
Code English
RINTAL
Code English
FEBANTEL [MI]
Common Name English
CARBAMIC ACID, ((2-((METHOXYACETYL)AMINO)-4-(PHENYLTHIO)PHENYL)CARBONIMIDOYL)BIS-, DIMETHYL ESTER
Systematic Name English
BAYH-5757
Code English
BAYVH-5757
Code English
COMBOTEL
Code English
FEBANTEL FOR VETERINARY USE
EP  
Common Name English
BAY-H-5757
Code English
Classification Tree Code System Code
CFR 21 CFR 520.903D
Created by admin on Fri Dec 15 15:56:56 GMT 2023 , Edited by admin on Fri Dec 15 15:56:56 GMT 2023
CFR 21 CFR 520.903B
Created by admin on Fri Dec 15 15:56:56 GMT 2023 , Edited by admin on Fri Dec 15 15:56:56 GMT 2023
CFR 21 CFR 520.903
Created by admin on Fri Dec 15 15:56:56 GMT 2023 , Edited by admin on Fri Dec 15 15:56:56 GMT 2023
WHO-VATC QP52AC05
Created by admin on Fri Dec 15 15:56:56 GMT 2023 , Edited by admin on Fri Dec 15 15:56:56 GMT 2023
CFR 21 CFR 520.903A
Created by admin on Fri Dec 15 15:56:56 GMT 2023 , Edited by admin on Fri Dec 15 15:56:56 GMT 2023
CFR 21 CFR 520.1872
Created by admin on Fri Dec 15 15:56:56 GMT 2023 , Edited by admin on Fri Dec 15 15:56:56 GMT 2023
CFR 21 CFR 520.903E
Created by admin on Fri Dec 15 15:56:56 GMT 2023 , Edited by admin on Fri Dec 15 15:56:56 GMT 2023
WHO-VATC QP52AC55
Created by admin on Fri Dec 15 15:56:56 GMT 2023 , Edited by admin on Fri Dec 15 15:56:56 GMT 2023
NCI_THESAURUS C250
Created by admin on Fri Dec 15 15:56:56 GMT 2023 , Edited by admin on Fri Dec 15 15:56:56 GMT 2023
Code System Code Type Description
NCI_THESAURUS
C65625
Created by admin on Fri Dec 15 15:56:56 GMT 2023 , Edited by admin on Fri Dec 15 15:56:56 GMT 2023
PRIMARY
DAILYMED
S75C401OS1
Created by admin on Fri Dec 15 15:56:56 GMT 2023 , Edited by admin on Fri Dec 15 15:56:56 GMT 2023
PRIMARY
RS_ITEM_NUM
1269356
Created by admin on Fri Dec 15 15:56:56 GMT 2023 , Edited by admin on Fri Dec 15 15:56:56 GMT 2023
PRIMARY
CAS
58306-30-2
Created by admin on Fri Dec 15 15:56:56 GMT 2023 , Edited by admin on Fri Dec 15 15:56:56 GMT 2023
PRIMARY
MESH
C017309
Created by admin on Fri Dec 15 15:56:56 GMT 2023 , Edited by admin on Fri Dec 15 15:56:56 GMT 2023
PRIMARY
ECHA (EC/EINECS)
261-205-0
Created by admin on Fri Dec 15 15:56:56 GMT 2023 , Edited by admin on Fri Dec 15 15:56:56 GMT 2023
PRIMARY
EVMPD
SUB07518MIG
Created by admin on Fri Dec 15 15:56:56 GMT 2023 , Edited by admin on Fri Dec 15 15:56:56 GMT 2023
PRIMARY
DRUG BANK
DB11409
Created by admin on Fri Dec 15 15:56:56 GMT 2023 , Edited by admin on Fri Dec 15 15:56:56 GMT 2023
PRIMARY
INN
4385
Created by admin on Fri Dec 15 15:56:56 GMT 2023 , Edited by admin on Fri Dec 15 15:56:56 GMT 2023
PRIMARY
SMS_ID
100000081766
Created by admin on Fri Dec 15 15:56:56 GMT 2023 , Edited by admin on Fri Dec 15 15:56:56 GMT 2023
PRIMARY
FDA UNII
S75C401OS1
Created by admin on Fri Dec 15 15:56:56 GMT 2023 , Edited by admin on Fri Dec 15 15:56:56 GMT 2023
PRIMARY
MERCK INDEX
m5251
Created by admin on Fri Dec 15 15:56:56 GMT 2023 , Edited by admin on Fri Dec 15 15:56:56 GMT 2023
PRIMARY Merck Index
ChEMBL
CHEMBL1080983
Created by admin on Fri Dec 15 15:56:56 GMT 2023 , Edited by admin on Fri Dec 15 15:56:56 GMT 2023
PRIMARY
PUBCHEM
135449328
Created by admin on Fri Dec 15 15:56:56 GMT 2023 , Edited by admin on Fri Dec 15 15:56:56 GMT 2023
PRIMARY
EPA CompTox
DTXSID6046898
Created by admin on Fri Dec 15 15:56:56 GMT 2023 , Edited by admin on Fri Dec 15 15:56:56 GMT 2023
PRIMARY
RXCUI
24805
Created by admin on Fri Dec 15 15:56:56 GMT 2023 , Edited by admin on Fri Dec 15 15:56:56 GMT 2023
PRIMARY RxNorm
Related Record Type Details
Structure of METHYL ((2-((METHOXYACETYL)AMINO)-4-(PHENYLTHIO)PHENYL)CARBAMIMIDOYL)CARBAMATE
IMPURITY -> PARENT
Structure of 2-(METHOXYMETHYL)-6-(PHENYLTHIO)-1H-BENZIMIDAZOLE
IMPURITY -> PARENT
Related Record Type Details
Structure of FEBANTEL
ACTIVE MOIETY
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966