DANVATIRSEN SODIUM

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National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Sat Dec 16 13:54:23 UTC 2023` Edited by `admin` on `Sat Dec 16 13:54:23 UTC 2023`
Nucleic Acid Type	OLIGONUCLEOTIDE
Nucleic Acid Subtype
Sequence Type	COMPLETE
Record UNII	S6A2UYH57V
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DANVATIRSEN SODIUM

Official Name

English

DANVATIRSEN PENTADECASODIUM

Common Name

English

DANVATIRSEN SODIUM [USAN]

Common Name

English

AZD9150 SODIUM

Code

English

DNA, D(P-THIO)(((5'.XI.)-2',5'-ANHYDRO-6'-DEOXY-4'-C-(HYDROXYMETHYL)-.ALPHA.-L-LYXO-HEXOFURANO)M5C-(3'->4')-((5'.XI.)-2',5'-ANHYDRO-6'-DEOXY-4'-C-(HYDROXYMETHYL)-.ALPHA.-L-LYXO-HEXOFURANO)M5U-(3'->4')-((5'.XI.)-2',5'-ANHYDRO-6'-DEOXY-4'-C-(HYDROXYMETHYL)

Systematic Name

English

AZD-9150 PENTADECASODIUM

Code

English

ALL-P-AMBO-2'-O,4'-C-((1S)-ETHANE-1,1-DIYL)-5-METHYL-P-THIOCYTIDYLYL-(3'->5')-2'-O,4'-C-((1S)-ETHANE-1,1-DIYL)-5-METHYL-P-THIOURIDYLYL-(3'->5')-2'-O,4'-C-((1S)-2-ETHANE-1,1-DIYL)-P-THIOADENYLYL-(3'->5')-P-THIOTHYMIDYLYL-(3'->5')-P-THIOTHYMIDYLYL-(3'->5')

Systematic Name

English

AZD-9150 SODIUM

Code

English

Code System Code Type Description

CAS

2135720-99-7

Created by admin on Sat Dec 16 13:54:23 UTC 2023 , Edited by admin on Sat Dec 16 13:54:23 UTC 2023

PRIMARY

USAN

FG-84

Created by admin on Sat Dec 16 13:54:23 UTC 2023 , Edited by admin on Sat Dec 16 13:54:23 UTC 2023

PRIMARY

NCI_THESAURUS

C169875

Created by admin on Sat Dec 16 13:54:23 UTC 2023 , Edited by admin on Sat Dec 16 13:54:23 UTC 2023

PRIMARY

FDA UNII

S6A2UYH57V

Created by admin on Sat Dec 16 13:54:23 UTC 2023 , Edited by admin on Sat Dec 16 13:54:23 UTC 2023

PRIMARY

SMS_ID

100000175533

Created by admin on Sat Dec 16 13:54:23 UTC 2023 , Edited by admin on Sat Dec 16 13:54:23 UTC 2023

PRIMARY

Sugar	Site Range	Site Count
Deoxyribose (DNA)	1_4-1_13	10 / 16
	1_1-1_3;1_14-1_16	6 / 16

Linkage	Site Range	Site Count
Sodium Phosporothioate	1_2-1_16	15 / 15

Related Record Type Details


					31N550RD05

PARENT -> SALT/SOLVATE

Related Record Type Details


					31N550RD05

ACTIVE MOIETY

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
NUCLEOSIDE_SUBSTITUTION	[1_2]	SITE_SPECIFIC			2'-O,4'-C-((1S)-ETHANE-1,1-DIYL).BETA.-D-RIBOSE 5-METHYL URIDINE	I12206O08P
NUCLEOSIDE_SUBSTITUTION	[1_1] [1_16]	SITE_SPECIFIC			2'-O,4'-C-((1S)-ETHANE-1,1-DIYL).BETA.-D-RIBOSE 5-METHYL CYTIDINE	7XRE49320R
NUCLEOSIDE_SUBSTITUTION	[1_13]	SITE_SPECIFIC			5-METHYLDEOXYCYTIDINE	B200GV71QM

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	PHYSICAL