MEXAZOLAM

Details

Stereochemistry	MIXED
Molecular Formula	C18H16Cl2N2O2
Molecular Weight	363.238
Optical Activity	UNSPECIFIED
Defined Stereocenters	0 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1COC2(N1CC(=O)NC3=CC=C(Cl)C=C23)C4=C(Cl)C=CC=C4

InChI

InChIKey=ANUCDXCTICZJRH-UHFFFAOYSA-N

InChI=1S/C18H16Cl2N2O2/c1-11-10-24-18(13-4-2-3-5-15(13)20)14-8-12(19)6-7-16(14)21-17(23)9-22(11)18/h2-8,11H,9-10H2,1H3,(H,21,23)

HIDE SMILES / InChI

Molecular Formula	C18H16Cl2N2O2
Molecular Weight	363.238
Charge	0
Count

Stereochemistry	MIXED
Additional Stereochemistry	No
Defined Stereocenters	0 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/26000220
Curator's Comment: description was created based on several sources, including http://www.rad-ar.or.jp/siori/english/kekka.cgi?n=1538

Mexazolam (trade names Melex and Sedoxil) is indicated for the management of anxiety with or without psychoneurotic conditions. In adult patients, the recommended daily dosage of mexazolam is 1-3 mg, administered three times daily. Mexazolam is metabolised via the CYP3A4 pathway.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Anxiety 267 Sources: http://www.rad-ar.or.jp/siori/english/kekka.cgi?n=1538	Curative		Phase III 656	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method.	2010 Dec	21818443
Generalized skin drug eruption to natalizumab in a patient with multiple sclerosis.	2010 Jun 15	20579469

Patents

Sample Use Guides

In Vivo Use Guide

1-3 mg, administered three times daily

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:11:03 UTC 2023` Edited by `admin` on `Fri Dec 15 16:11:03 UTC 2023`
Record UNII	S5969B6237
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

MEXAZOLAM

Official Name

English

MEXAZOLAM [MART.]

Common Name

English

10-CHLORO-11B-(O-CHLOROPHENYL)-2,3,7,11B-TETRAHYDRO-3-METHYLOXAZOLO(3,2-D)(1,4)BENZODIAZEPIN-6(5H)-ONE

Common Name

English

mexazolam [INN]

Common Name

English

MEXAZOLAM [MI]

Common Name

English

Mexazolam [WHO-DD]

Common Name

English

10-CHLORO-11B-(2-CHLOROPHENYL)-2,3,7,11B-TETRAHYDRO-3-METHYLOXAZOLO(3,2-D)(1,4)BENZODIAZEPIN-6(5H)-ONE

Common Name

English

MEXAZOLAM [JAN]

Common Name

English

MELEX

Brand Name

English

CS-386

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C1012