U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry MIXED
Molecular Formula C18H16Cl2N2O2
Molecular Weight 363.238
Optical Activity UNSPECIFIED
Defined Stereocenters 0 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MEXAZOLAM

SMILES

CC1COC2(N1CC(=O)NC3=CC=C(Cl)C=C23)C4=C(Cl)C=CC=C4

InChI

InChIKey=ANUCDXCTICZJRH-UHFFFAOYSA-N
InChI=1S/C18H16Cl2N2O2/c1-11-10-24-18(13-4-2-3-5-15(13)20)14-8-12(19)6-7-16(14)21-17(23)9-22(11)18/h2-8,11H,9-10H2,1H3,(H,21,23)

HIDE SMILES / InChI
Molecular Formula C18H16Cl2N2O2
Molecular Weight 363.238
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry MIXED
Additional Stereochemistry No
Defined Stereocenters 0 / 2
E/Z Centers 0
Optical Activity UNSPECIFIED

Description

Mexazolam (trade names Melex and Sedoxil) is indicated for the management of anxiety with or without psychoneurotic conditions. In adult patients, the recommended daily dosage of mexazolam is 1-3 mg, administered three times daily. Mexazolam is metabolised via the CYP3A4 pathway.

Approval Year

Unknown
139,594

Conditions

ConditionModalityTargetsHighest PhaseProduct
Anxiety
267
 Curative
Phase III
656
Unknown

PubMed

Patents

US20080279784A1
1

Sample Use Guides

In Vivo Use Guide
1-3 mg, administered three times daily
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Record UNII
S5969B6237
Record Status Validated (UNII)
Record Version
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966