MEXAZOLAM

Details

Stereochemistry	MIXED
Molecular Formula	C18H16Cl2N2O2
Molecular Weight	363.238
Optical Activity	UNSPECIFIED
Defined Stereocenters	0 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1COC2(N1CC(=O)NC3=CC=C(Cl)C=C23)C4=C(Cl)C=CC=C4

InChI

InChIKey=ANUCDXCTICZJRH-UHFFFAOYSA-N

InChI=1S/C18H16Cl2N2O2/c1-11-10-24-18(13-4-2-3-5-15(13)20)14-8-12(19)6-7-16(14)21-17(23)9-22(11)18/h2-8,11H,9-10H2,1H3,(H,21,23)

HIDE SMILES / InChI

Molecular Formula	C18H16Cl2N2O2
Molecular Weight	363.238
Charge	0
Count

Stereochemistry	MIXED
Additional Stereochemistry	No
Defined Stereocenters	0 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/26000220
Curator's Comment: description was created based on several sources, including http://www.rad-ar.or.jp/siori/english/kekka.cgi?n=1538

Mexazolam (trade names Melex and Sedoxil) is indicated for the management of anxiety with or without psychoneurotic conditions. In adult patients, the recommended daily dosage of mexazolam is 1-3 mg, administered three times daily. Mexazolam is metabolised via the CYP3A4 pathway.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Anxiety 267 Sources: http://www.rad-ar.or.jp/siori/english/kekka.cgi?n=1538	Curative		Phase III 656	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
A comparison of the effects of 3-hydroxy-3-methylglutaryl-coenzyme a (HMG-CoA) reductase inhibitors on the CYP3A4-dependent oxidation of mexazolam in vitro.	2001 Mar	11181496
Sex difference in inhibition of in vitro mexazolam metabolism by various 3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibitors in rat liver microsomes.	2002 Aug	12124308
Psychomotor and anxiolytic effects of mexazolam in patients with generalised anxiety disorder.	2003	17535036
The effects of concurrent atorvastatin therapy on the pharmacokinetics of intravenous midazolam.	2003 Sep	12911366
Do the pleiotropic effects of statins in the vasculature predict a role in inflammatory diseases?	2005	15743490
Passiflora for anxiety disorder.	2007 Jan 24	17253512
Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method.	2010 Dec	21818443
Generalized skin drug eruption to natalizumab in a patient with multiple sclerosis.	2010 Jun 15	20579469

Patents

Sample Use Guides

In Vivo Use Guide

1-3 mg, administered three times daily

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:11:03 GMT 2023` Edited by `admin` on `Fri Dec 15 16:11:03 GMT 2023`
Record UNII	S5969B6237
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

MEXAZOLAM

Official Name

English

MEXAZOLAM [MART.]

Common Name

English

10-CHLORO-11B-(O-CHLOROPHENYL)-2,3,7,11B-TETRAHYDRO-3-METHYLOXAZOLO(3,2-D)(1,4)BENZODIAZEPIN-6(5H)-ONE

Common Name

English

mexazolam [INN]

Common Name

English

MEXAZOLAM [MI]

Common Name

English

Mexazolam [WHO-DD]

Common Name

English

10-CHLORO-11B-(2-CHLOROPHENYL)-2,3,7,11B-TETRAHYDRO-3-METHYLOXAZOLO(3,2-D)(1,4)BENZODIAZEPIN-6(5H)-ONE

Common Name

English

MEXAZOLAM [JAN]

Common Name

English

MELEX

Brand Name

English

CS-386

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C1012