LINAROTENE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C23H30N2O2S
Molecular Weight	398.562
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C\C(=N/NC1=CC=C(C=C1)S(C)(=O)=O)C2=CC=C3C(=C2)C(C)(C)CCC3(C)C

InChI

InChIKey=KGRBTTOECAZCNW-LFVJCYFKSA-N

InChI=1S/C23H30N2O2S/c1-16(24-25-18-8-10-19(11-9-18)28(6,26)27)17-7-12-20-21(15-17)23(4,5)14-13-22(20,2)3/h7-12,15,25H,13-14H2,1-6H3/b24-16+

HIDE SMILES / InChI

Molecular Formula	C23H30N2O2S
Molecular Weight	398.562
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Description
Sources: https://adisinsight.springer.com/drugs/800008151 | https://apps.who.int/iris/bitstream/handle/10665/275695/WHO-EMP-RHT-TSN-2018.1-eng.pdf

Linarotene is arotinoid derivative. It is an antikeratolytic agent. Linarotene had been in preclinical phase by Ortho Pharmaceutical (Johnson & Johnson) and BASF Pharma for the treatment of skin disorders. However, this research was discontinued.

Originator

Approval Year

Substance Class	Chemical Created by `admin` on `Sat Dec 16 05:43:05 GMT 2023` Edited by `admin` on `Sat Dec 16 05:43:05 GMT 2023`
Record UNII	S3WF2KTK27
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

LINAROTENE

Official Name

English

BASF-52404

Code

English

LINAROTENE [USAN]

Common Name

English

RWJ-24834

Code

English

linarotene [INN]

Common Name

English

BASF 52404

Code

English

5',6',7',8'-TETRAHYDRO-5',5',8',8'-TETRAMETHYL-2'-ACETONAPHTHONE (E)-(P-(METHYLSULFONYL)PHENYL)HYDRAZONE

Systematic Name

English

RWJ 24834

Code

English

ETHANONE, 1-(5,6,7,8-TETRAHYDRO-5,5,8,8-TETRAMETHYL-2-NAPHTHALENYL)-, (4-(METHYLSULFONYL)PHENYL)HYDRAZONE, (E)-

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C26017