Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C10H20O2.H2O |
| Molecular Weight | 190.2799 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
O.CC(C)(O)[C@H]1CC[C@@](C)(O)CC1
InChI
InChIKey=JGKJMBOJWVAMIJ-OFAZAQPOSA-N
InChI=1S/C10H20O2.H2O/c1-9(2,11)8-4-6-10(3,12)7-5-8;/h8,11-12H,4-7H2,1-3H3;1H2/t8-,10+;
| Molecular Formula | C10H20O2 |
| Molecular Weight | 172.2646 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
| Molecular Formula | H2O |
| Molecular Weight | 18.0153 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
DescriptionCurator's Comment: Description was created using several sources including: http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfCFR/CFRSearch.cfm?fr=310.545
http://www.fda.gov/regulatoryinformation/dockets/ucm113857.htm; https://www.drugs.com/uk/pdf/leaflet/849432.pdf; https://www.ncbi.nlm.nih.gov/pubmed/?term=19557607; https://www.ncbi.nlm.nih.gov/pubmed/?term=19551736
Curator's Comment: Description was created using several sources including: http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfCFR/CFRSearch.cfm?fr=310.545
http://www.fda.gov/regulatoryinformation/dockets/ucm113857.htm; https://www.drugs.com/uk/pdf/leaflet/849432.pdf; https://www.ncbi.nlm.nih.gov/pubmed/?term=19557607; https://www.ncbi.nlm.nih.gov/pubmed/?term=19551736
Terpin hydrate is an expectorant commonly used to loosen mucus in patients presenting with acute or chronic bronchitis, and related conditions. Terpin is derived from oil of turpentine, oregano, thyme and eucalyptus. In 1855 Lepin who first investigated terpin reported that it acted upon the mucous membranes and also the nervous system in a manner similar to the oil of turpentine. Terpin hydrate was available in the USA in 1907 in the preparations such as Elixir of Terpin Hydrate alone or in combination with codein or heroin as an antitussives. It was banned by the U.S. Food and Drug Administration (FDA) in the 1990s due to lack of proof of efficacy but is a medicine available in a number of countries worldwide commonly used in combination with codein. At present it is FDA approved for as an OTC use in combination formulations (with acetaminophen and other drugs) used as internal analgesics. Terpin was recently introduced as a natural topical insect repellent.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Field evaluation of three plant-based insect repellents against malaria vectors in Vaca Diez Province, the Bolivian Amazon. | 2002 Jun |
|
| Repellency of IR3535, KBR3023, para-menthane-3,8-diol, and deet to black salt marsh mosquitoes (Diptera: Culicidae) in the Everglades National Park. | 2002 Nov |
|
| Repellent activities of stereoisomers of p-menthane-3,8-diols against Anopheles gambiae (Diptera: Culicidae). | 2002 Sep |
|
| Enhancement effect of p-menthane-3,8-diol on in vitro permeation of antipyrine and indomethacin through Yucatan micropig skin. | 2004 Jul |
|
| Repellency of MyggA Natural spray (para-menthane-3,8-diol) and RB86 (neem oil) against the tick Ixodes ricinus (Acari: Ixodidae) in the field in east-central Sweden. | 2006 |
|
| Repellency of oils of lemon eucalyptus, geranium, and lavender and the mosquito repellent MyggA natural to Ixodes ricinus (Acari: Ixodidae) in the laboratory and field. | 2006 Jul |
|
| PMD, a registered botanical mosquito repellent with deet-like efficacy. | 2006 Sep |
|
| A low-cost repellent for malaria vectors in the Americas: results of two field trials in Guatemala and Peru. | 2007 Aug 1 |
|
| Fragrance material review on geranodyle. | 2008 Nov |
|
| Percutaneous absorption of an insect repellent p-menthane-3,8-DIOL: a model for human dermal absorption. | 2009 |
|
| Acaricidal effects of Corymbia citriodora oil containing para-menthane-3,8-diol against nymphs of Ixodes ricinus (Acari: Ixodidae). | 2009 Jul |
|
| Limitation of using synthetic human odours to test mosquito repellents. | 2009 Jul 7 |
|
| Effective insect repellent formulation in both surfactantless and classical microemulsions with a long-lasting protection for human beings. | 2009 Jun |
|
| Adverse drug effects in hospitalized elderly: data from the healthcare cost and utilization project. | 2010 |
|
| tert-Butyl 6-bromo-1,4-dimethyl-9H-carbazole-9-carboxyl-ate. | 2010 Jul 10 |
Sample Use Guides
Adults: Take 1 x 5ml (32.5 mg terpin hydrate) spoonful, diluted with water, after food. Repeat after 6 hours if required, but not more than 3 doses in 24 hours. The elderly: Ask your doctor for advice.
A lower dose may be more suitable. Do not give to children under 18 years old
Route of Administration:
Oral
| Substance Class |
Chemical
Created
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admin
on
Edited
Fri Dec 15 15:03:14 GMT 2023
by
admin
on
Fri Dec 15 15:03:14 GMT 2023
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| Record UNII |
S3V868548T
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| Record Status |
Validated (UNII)
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CHEMBL1651998
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| Related Record | Type | Details | ||
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PARENT -> SALT/SOLVATE | |||
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ANHYDROUS->SOLVATE |
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IMPURITY -> PARENT |
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IMPURITY -> PARENT |
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IMPURITY -> PARENT |
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IMPURITY -> PARENT |
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