Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C10H20O2.H2O |
| Molecular Weight | 190.2799 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
O.CC(C)(O)[C@H]1CC[C@@](C)(O)CC1
InChI
InChIKey=JGKJMBOJWVAMIJ-OFAZAQPOSA-N
InChI=1S/C10H20O2.H2O/c1-9(2,11)8-4-6-10(3,12)7-5-8;/h8,11-12H,4-7H2,1-3H3;1H2/t8-,10+;
| Molecular Formula | C10H20O2 |
| Molecular Weight | 172.2646 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
| Molecular Formula | H2O |
| Molecular Weight | 18.0153 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
DescriptionCurator's Comment: Description was created using several sources including: http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfCFR/CFRSearch.cfm?fr=310.545
http://www.fda.gov/regulatoryinformation/dockets/ucm113857.htm; https://www.drugs.com/uk/pdf/leaflet/849432.pdf; https://www.ncbi.nlm.nih.gov/pubmed/?term=19557607; https://www.ncbi.nlm.nih.gov/pubmed/?term=19551736
Curator's Comment: Description was created using several sources including: http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfCFR/CFRSearch.cfm?fr=310.545
http://www.fda.gov/regulatoryinformation/dockets/ucm113857.htm; https://www.drugs.com/uk/pdf/leaflet/849432.pdf; https://www.ncbi.nlm.nih.gov/pubmed/?term=19557607; https://www.ncbi.nlm.nih.gov/pubmed/?term=19551736
Terpin hydrate is an expectorant commonly used to loosen mucus in patients presenting with acute or chronic bronchitis, and related conditions. Terpin is derived from oil of turpentine, oregano, thyme and eucalyptus. In 1855 Lepin who first investigated terpin reported that it acted upon the mucous membranes and also the nervous system in a manner similar to the oil of turpentine. Terpin hydrate was available in the USA in 1907 in the preparations such as Elixir of Terpin Hydrate alone or in combination with codein or heroin as an antitussives. It was banned by the U.S. Food and Drug Administration (FDA) in the 1990s due to lack of proof of efficacy but is a medicine available in a number of countries worldwide commonly used in combination with codein. At present it is FDA approved for as an OTC use in combination formulations (with acetaminophen and other drugs) used as internal analgesics. Terpin was recently introduced as a natural topical insect repellent.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| tert-Butyl 6-bromo-1,4-dimethyl-9H-carbazole-9-carboxyl-ate. | 2010-07-10 |
|
| Adverse drug effects in hospitalized elderly: data from the healthcare cost and utilization project. | 2010 |
|
| Limitation of using synthetic human odours to test mosquito repellents. | 2009-07-07 |
|
| Acaricidal effects of Corymbia citriodora oil containing para-menthane-3,8-diol against nymphs of Ixodes ricinus (Acari: Ixodidae). | 2009-07 |
|
| Effective insect repellent formulation in both surfactantless and classical microemulsions with a long-lasting protection for human beings. | 2009-06 |
|
| Percutaneous absorption of an insect repellent p-menthane-3,8-DIOL: a model for human dermal absorption. | 2009 |
|
| Fragrance material review on geranodyle. | 2008-11 |
|
| A low-cost repellent for malaria vectors in the Americas: results of two field trials in Guatemala and Peru. | 2007-08-01 |
|
| PMD, a registered botanical mosquito repellent with deet-like efficacy. | 2006-09 |
|
| Repellency of oils of lemon eucalyptus, geranium, and lavender and the mosquito repellent MyggA natural to Ixodes ricinus (Acari: Ixodidae) in the laboratory and field. | 2006-07 |
|
| Repellency of MyggA Natural spray (para-menthane-3,8-diol) and RB86 (neem oil) against the tick Ixodes ricinus (Acari: Ixodidae) in the field in east-central Sweden. | 2006 |
|
| Enhancement effect of p-menthane-3,8-diol on in vitro permeation of antipyrine and indomethacin through Yucatan micropig skin. | 2004-07 |
|
| Repellency of IR3535, KBR3023, para-menthane-3,8-diol, and deet to black salt marsh mosquitoes (Diptera: Culicidae) in the Everglades National Park. | 2002-11 |
|
| Repellent activities of stereoisomers of p-menthane-3,8-diols against Anopheles gambiae (Diptera: Culicidae). | 2002-09 |
|
| Field evaluation of three plant-based insect repellents against malaria vectors in Vaca Diez Province, the Bolivian Amazon. | 2002-06 |
Sample Use Guides
Adults: Take 1 x 5ml (32.5 mg terpin hydrate) spoonful, diluted with water, after food. Repeat after 6 hours if required, but not more than 3 doses in 24 hours. The elderly: Ask your doctor for advice.
A lower dose may be more suitable. Do not give to children under 18 years old
Route of Administration:
Oral
| Substance Class |
Chemical
Created
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admin
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Edited
Mon Mar 31 17:36:53 GMT 2025
by
admin
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Mon Mar 31 17:36:53 GMT 2025
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| Record UNII |
S3V868548T
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| Record Status |
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PARENT -> SALT/SOLVATE | |||
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ANHYDROUS->SOLVATE |
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IMPURITY -> PARENT |
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IMPURITY -> PARENT |
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