Details
Stereochemistry | ACHIRAL |
Molecular Formula | C7H6NO3.Na.2H2O |
Molecular Weight | 211.1478 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
O.O.[Na+].NC1=CC(O)=C(C=C1)C([O-])=O
InChI
InChIKey=GMUQJDAYXZXBOT-UHFFFAOYSA-M
InChI=1S/C7H7NO3.Na.2H2O/c8-4-1-2-5(7(10)11)6(9)3-4;;;/h1-3,9H,8H2,(H,10,11);;2*1H2/q;+1;;/p-1
Molecular Formula | H2O |
Molecular Weight | 18.0153 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Molecular Formula | Na |
Molecular Weight | 22.9898 |
Charge | 1 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Molecular Formula | C7H7NO3 |
Molecular Weight | 153.1354 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
DescriptionSources: http://www.drugbank.ca/drugs/DB00233Curator's Comment: Description was created based on several sources, including http://www.rxlist.com/paser-drug.htm
Sources: http://www.drugbank.ca/drugs/DB00233
Curator's Comment: Description was created based on several sources, including http://www.rxlist.com/paser-drug.htm
4-AMINOSALICYLIC ACID (Paser) is an anti-tuberculosis drug used to treat tuberculosis in combination with other active agents. 4-AMINOSALICYLIC ACID (Paser) is most commonly used in patients with Multi-drug Resistant TB (MDR-TB) or when isoniazid and rifampin use is not possible due to a combination of resistance and/or intolerance. There are two mechanisms responsible for aminosalicylic acid's bacteriostatic action against Mycobacterium tuberculosis. Firstly, aminosalicylic acid inhibits folic acid synthesis (without potentiation with antifolic compounds). The binding of para-aminobenzoic acid to pteridine synthetase acts as the first step in the folic acid synthesis. Aminosalicylic acid binds pteridine synthetase with greater affinity than para-aminobenzoic acid, effectively inhibiting the synthesis of folic acid. As bacteria are unable to use external sources of folic acid, cell growth and multiplication slow. Secondly, the aminosalicylic acid may inhibit the synthesis of the cell wall component, mycobactin, thus reducing iron uptake by M. tuberculosis.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL6065 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Sources: http://www.rxlist.com/paser-drug.htm |
Primary | PASER Approved UseTuberculosis Launch Date1994 |
||
Primary | PASER Approved UseUnknown Launch Date1994 |
|||
Primary | Unknown Approved UseUnknown |
Cmax
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
53.63 mg/L EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/31682027/ |
4 g 2 times / day multiple, oral dose: 4 g route of administration: Oral experiment type: MULTIPLE co-administered: |
AMINOSALICYLIC ACID plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: FED |
|
82.69 mg/L EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/31682027/ |
8 g 1 times / day multiple, oral dose: 8 g route of administration: Oral experiment type: MULTIPLE co-administered: |
AMINOSALICYLIC ACID plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: FED |
|
20 μg/mL |
4 g single, oral dose: 4 g route of administration: Oral experiment type: SINGLE co-administered: |
AMINOSALICYLIC ACID plasma | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
|
16.36 mg/L EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/31682027/ |
8 g 1 times / day multiple, oral dose: 8 g route of administration: Oral experiment type: MULTIPLE co-administered: |
4-ACETAMIDOSALICYLIC ACID plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: FED |
|
14.59 mg/L EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/31682027/ |
4 g 2 times / day multiple, oral dose: 4 g route of administration: Oral experiment type: MULTIPLE co-administered: |
4-ACETAMIDOSALICYLIC ACID plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: FED |
AUC
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
414.07 mg × h/L EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/31682027/ |
4 g 2 times / day multiple, oral dose: 4 g route of administration: Oral experiment type: MULTIPLE co-administered: |
AMINOSALICYLIC ACID plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: FED |
|
690.35 mg × h/L EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/31682027/ |
8 g 1 times / day multiple, oral dose: 8 g route of administration: Oral experiment type: MULTIPLE co-administered: |
AMINOSALICYLIC ACID plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: FED |
|
142.49 mg × h/L EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/31682027/ |
8 g 1 times / day multiple, oral dose: 8 g route of administration: Oral experiment type: MULTIPLE co-administered: |
4-ACETAMIDOSALICYLIC ACID plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: FED |
|
145.02 mg × h/L EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/31682027/ |
4 g 2 times / day multiple, oral dose: 4 g route of administration: Oral experiment type: MULTIPLE co-administered: |
4-ACETAMIDOSALICYLIC ACID plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: FED |
T1/2
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
1.62 h |
4 g single, oral dose: 4 g route of administration: Oral experiment type: SINGLE co-administered: |
AMINOSALICYLIC ACID plasma | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
Funbound
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
45% |
4 g single, oral dose: 4 g route of administration: Oral experiment type: SINGLE co-administered: |
AMINOSALICYLIC ACID plasma | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
Doses
Dose | Population | Adverse events |
---|---|---|
3 g 2 times / day multiple, oral Highest studied dose Dose: 3 g, 2 times / day Route: oral Route: multiple Dose: 3 g, 2 times / day Sources: Page: p.356 |
unhealthy, 45.5 n = 23 Health Status: unhealthy Condition: Ulcerative colitis Age Group: 45.5 Sex: M+F Population Size: 23 Sources: Page: p.356 |
Disc. AE: Dyspepsia, Lipase increased... AEs leading to discontinuation/dose reduction: Dyspepsia (severe, 4.3%) Sources: Page: p.356Lipase increased (4.3%) Aspartate aminotransferase abnormal (4.3%) |
4 g 3 times / day multiple, oral Recommended Dose: 4 g, 3 times / day Route: oral Route: multiple Dose: 4 g, 3 times / day Sources: |
unhealthy n = 7492 Health Status: unhealthy Condition: Tuberculosis Sex: M+F Population Size: 7492 Sources: |
Disc. AE: Drug-induced hepatitis... AEs leading to discontinuation/dose reduction: Drug-induced hepatitis (0.5%) Sources: |
AEs
AE | Significance | Dose | Population |
---|---|---|---|
Aspartate aminotransferase abnormal | 4.3% Disc. AE |
3 g 2 times / day multiple, oral Highest studied dose Dose: 3 g, 2 times / day Route: oral Route: multiple Dose: 3 g, 2 times / day Sources: Page: p.356 |
unhealthy, 45.5 n = 23 Health Status: unhealthy Condition: Ulcerative colitis Age Group: 45.5 Sex: M+F Population Size: 23 Sources: Page: p.356 |
Lipase increased | 4.3% Disc. AE |
3 g 2 times / day multiple, oral Highest studied dose Dose: 3 g, 2 times / day Route: oral Route: multiple Dose: 3 g, 2 times / day Sources: Page: p.356 |
unhealthy, 45.5 n = 23 Health Status: unhealthy Condition: Ulcerative colitis Age Group: 45.5 Sex: M+F Population Size: 23 Sources: Page: p.356 |
Dyspepsia | severe, 4.3% Disc. AE |
3 g 2 times / day multiple, oral Highest studied dose Dose: 3 g, 2 times / day Route: oral Route: multiple Dose: 3 g, 2 times / day Sources: Page: p.356 |
unhealthy, 45.5 n = 23 Health Status: unhealthy Condition: Ulcerative colitis Age Group: 45.5 Sex: M+F Population Size: 23 Sources: Page: p.356 |
Drug-induced hepatitis | 0.5% Disc. AE |
4 g 3 times / day multiple, oral Recommended Dose: 4 g, 3 times / day Route: oral Route: multiple Dose: 4 g, 3 times / day Sources: |
unhealthy n = 7492 Health Status: unhealthy Condition: Tuberculosis Sex: M+F Population Size: 7492 Sources: |
PubMed
Title | Date | PubMed |
---|---|---|
Tuberculostatic derivatives of rho-aminobenzoic acid; esters and amides of 4-aminosalicylic acid. | 1948 |
|
A procedure for the determination of 4-aminosalicylic acid (p-aminosalicylic acid) in blood and in urine. | 1949 Feb |
|
[Ethers of 4-aminosalicylic acid]. | 1953 May |
|
A double-blind clinical trial to compare the effects of 4-aminosalicylic acid to 5-aminosalicylic acid in topical treatment of ulcerative colitis. | 1984 |
|
4-Aminosalicylic acid retention enemas in treatment of distal colitis. | 1987 Jul |
|
Treatment of left-sided ulcerative colitis with 4-aminosalicylic acid enemas. A double-blind, placebo-controlled trial. | 1988 Feb |
|
[Inhibition of intestinal leukotriene formation as a possible mechanism of action of sulfasalazine, 5-aminosalicylic acid and 4-aminosalicylic acid]. | 1988 Nov 15 |
|
Experience with topical administration of 4-aminosalicylic acid in ulcerative colitis. | 1989 Feb |
|
4-Aminosalicylic acid enemas for ulcerative colitis. | 1989 Feb 25 |
|
Luminal concentrations of orally ingested 4-aminosalicylic acid as determined by in-vivo equilibrium dialysis. | 1990 Dec |
|
Double blind, controlled trial of 4-aminosalicylic acid and prednisolone enemas in distal ulcerative colitis. | 1992 Jul |
|
A prospective randomized double blind trial comparing prednisolone and 4-aminosalicylic acid enemas in acute distal ulcerative colitis. | 1992 Mar-Apr |
|
Oral 4-aminosalicylic acid versus 5-aminosalicylic acid slow release tablets. Double blind, controlled pilot study in the maintenance treatment of Crohn's ileocolitis. | 1994 Aug |
|
Tolerance of 4-aminosalicylic acid enemas in patients with inflammatory bowel disease and 5-aminosalicylic-induced acute pancreatitis. | 2004 May |
|
Colon-specific prodrugs of 4-aminosalicylic acid for inflammatory bowel disease. | 2014 Apr 7 |
Patents
Sample Use Guides
The adult dosage of four grams (one packet) three times per day or correspondingly smaller doses in children.
Route of Administration:
Oral
In Vitro Use Guide
Curator's Comment: The developed nanodelivery formulation based on para-aminosalicylic acid (PAS) and zinc layered hydroxide has a fourfold higher efficacy of PAS against mycobacterium tuberculosis with a minimum inhibitory concentration (MIC) found to be at 1.40 ug/mL compared to the free drug PAS with a MIC of 5.0 ug/mL.
5.0 ug/mL MIC against mycobacterium tuberculosis.
Substance Class |
Chemical
Created
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Edited
Fri Dec 15 15:36:04 GMT 2023
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Record UNII |
S38B9W6AXW
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Record Status |
Validated (UNII)
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Record Version |
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Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C280
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WHO-ATC |
J04AA02
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FDA ORPHAN DRUG |
68592
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WHO-VATC |
QJ04AA02
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6018-19-5
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m1743
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CHEMBL1169
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89753
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S38B9W6AXW
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16211148
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C47958
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755862
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DTXSID5036638
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DBSALT001938
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100000088683
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