FLUPEROLONE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C22H29FO5
Molecular Weight	392.4611
Optical Activity	UNSPECIFIED
Defined Stereocenters	8 / 8
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]12CC[C@](O)(C(=O)[C@H](C)O)[C@@]1(C)C[C@H](O)[C@@]3(F)[C@@]2([H])CCC4=CC(=O)C=C[C@]34C

InChI

InChIKey=SLVCCRYLKTYUQP-DVTGEIKXSA-N

InChI=1S/C22H29FO5/c1-12(24)18(27)21(28)9-7-15-16-5-4-13-10-14(25)6-8-19(13,2)22(16,23)17(26)11-20(15,21)3/h6,8,10,12,15-17,24,26,28H,4-5,7,9,11H2,1-3H3/t12-,15-,16-,17-,19-,20-,21-,22-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C22H29FO5
Molecular Weight	392.4611
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	8 / 8
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://dtb.bmj.com/content/1/15/58 | https://www.ncbi.nlm.nih.gov/pubmed/13984971 | https://www.ncbi.nlm.nih.gov/pubmed/14209713

Fluperolone (P-1742 or Methral) is a topical fluorinated prednisolone derivative exerting an anti-inflammatory activity. It demonstrated effectivity in the treatment of various dermatoses.

Originator

Approval Year

PubMed

Title	Date	PubMed
A clinical trial of Fluperolone, a new topical steroid.	1963 Mar	13984971
A NEW SYNTHETIC CORTICOSTEROID--P.1742.	1964 Aug	14209713
CLINICAL TRIAL OF P-1742 TOPICAL OR FLUPEROLONE (9 FLUORO-21 METHYL PREDNISOLONE) IN PSORIASIS.	1964 Jun	14192684

Sample Use Guides

In Vivo Use Guide

0.1% ointment

Route of Administration: Transdermal

Substance Class	Chemical Created by `admin` on `Fri Dec 15 18:44:39 UTC 2023` Edited by `admin` on `Fri Dec 15 18:44:39 UTC 2023`
Record UNII	S33056JLS5
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

FLUPEROLONE

Official Name

English

Fluperolone [WHO-DD]

Common Name

English

9-FLUORO-11.BETA.,17.ALPHA.-DIHYDROXY-17-(S)-LACTOYLANDROSTA-1,4-DIEN-3-ONE

Common Name

English

fluperolone [INN]

Common Name

English

ANDROSTA-1,4-DIEN-3-ONE, 9-FLUORO-11,17-DIHYDROXY-17-(2-HYDROXY-1-OXOPROPYL)-, (11.BETA.,17.ALPHA.)-

Common Name

English

ANDROSTA-1,4-DIEN-3-ONE, 9-FLUORO-11.BETA.,17.ALPHA.-DIHYDROXY-17-LACTOYL-

Common Name

English

Classification Tree Code System Code

WHO-VATC

QD07AB05