| Stereochemistry | ACHIRAL |
| Molecular Formula | C15H10O2 |
| Molecular Weight | 222.2387 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
O=C1C=C(OC2=C1C=CC=C2)C3=CC=CC=C3
InChI
InChIKey=VHBFFQKBGNRLFZ-UHFFFAOYSA-N
InChI=1S/C15H10O2/c16-13-10-15(11-6-2-1-3-7-11)17-14-9-5-4-8-12(13)14/h1-10H
| Molecular Formula | C15H10O2 |
| Molecular Weight | 222.2387 |
| Charge | 0 |
| Count |
MOL RATIO
1 MOL RATIO (average) |
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Flavone belongs to the class of organic compounds known as flavones. Flavones are mainly found in cereals and herbs. Flavone is a less potent inhibitor of CYP1A1 than CYP1A2. Flavone inhibited the estrogen action without binding to the estrogen receptor by acting as a competitive agonist for aryl hydrocarbon receptor. This naturally occurring flavone was shown to be an effective inducer of benzpyrene hydroxylase in human liver microsomes in in vitro assays, and the inducing effect of the flavone was concentration-dependent.
Originator
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
| 116.5 µM [IC50] | |||
| 0.14 µM [IC50] | |||
| 0.066 µM [IC50] | |||
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
