PARSACLISIB HYDROCHLORIDE

Investigational

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C20H22ClFN6O2.ClH
Molecular Weight	469.34
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.CCOC1=C(C=C(Cl)C(F)=C1[C@@H]2CNC(=O)C2)[C@H](C)N3N=C(C)C4=C3N=CN=C4N

InChI

InChIKey=TWHUONANZMKBKX-ACMTZBLWSA-N

InChI=1S/C20H22ClFN6O2.ClH/c1-4-30-18-12(6-13(21)17(22)16(18)11-5-14(29)24-7-11)10(3)28-20-15(9(2)27-28)19(23)25-8-26-20;/h6,8,10-11H,4-5,7H2,1-3H3,(H,24,29)(H2,23,25,26);1H/t10-,11-;/m0./s1

HIDE SMILES / InChI

Molecular Formula	C20H22ClFN6O2
Molecular Weight	432.879
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

C_max

Value	Dose	Co-administered	Analyte	Population
793 nM CLINICAL TRIAL https://accp1.onlinelibrary.wiley.com/doi/full/10.1002/jcph.1653	10 mg single, oral dose: 10 mg route of administration: Oral experiment type: SINGLE co-administered:		PARSACLISIB plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
954 nM CLINICAL TRIAL https://accp1.onlinelibrary.wiley.com/doi/full/10.1002/jcph.1653	10 mg single, oral dose: 10 mg route of administration: Oral experiment type: SINGLE co-administered: Itraconazole	Itraconazole	PARSACLISIB plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
1650 nM CLINICAL TRIAL https://pubmed.ncbi.nlm.nih.gov/32515832/	20 mg single, oral dose: 20 mg route of administration: Oral experiment type: SINGLE co-administered:		PARSACLISIB plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED

AUC

Value	Dose	Co-administered	Analyte	Population
7500 nM × h CLINICAL TRIAL https://accp1.onlinelibrary.wiley.com/doi/full/10.1002/jcph.1653	10 mg single, oral dose: 10 mg route of administration: Oral experiment type: SINGLE co-administered:		PARSACLISIB plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
15600 nM × h CLINICAL TRIAL https://accp1.onlinelibrary.wiley.com/doi/full/10.1002/jcph.1653	10 mg single, oral dose: 10 mg route of administration: Oral experiment type: SINGLE co-administered: Itraconazole	Itraconazole	PARSACLISIB plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
14800 nM × h CLINICAL TRIAL https://pubmed.ncbi.nlm.nih.gov/32515832/	20 mg single, oral dose: 20 mg route of administration: Oral experiment type: SINGLE co-administered:		PARSACLISIB plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED

T_1/2

Value	Dose	Co-administered	Analyte	Population
13.2 h CLINICAL TRIAL https://accp1.onlinelibrary.wiley.com/doi/full/10.1002/jcph.1653	10 mg single, oral dose: 10 mg route of administration: Oral experiment type: SINGLE co-administered:		PARSACLISIB plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
21.1 h CLINICAL TRIAL https://accp1.onlinelibrary.wiley.com/doi/full/10.1002/jcph.1653	10 mg single, oral dose: 10 mg route of administration: Oral experiment type: SINGLE co-administered: Itraconazole	Itraconazole	PARSACLISIB plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
14.7 h CLINICAL TRIAL https://pubmed.ncbi.nlm.nih.gov/32515832/	20 mg single, oral dose: 20 mg route of administration: Oral experiment type: SINGLE co-administered:		PARSACLISIB plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED

F_unbound

Value	Dose	Co-administered	Analyte	Population
5.8% EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/31749910/	unknown, unknown		PARSACLISIB plasma	Homo sapiens population: UNKNOWN age: UNKNOWN sex: UNKNOWN food status: UNKNOWN

Substance Class	Chemical Created by `admin` on `Mon Mar 31 22:38:17 GMT 2025` Edited by `admin` on `Mon Mar 31 22:38:17 GMT 2025`
Record UNII	S0GJ8VM4P9
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

INCB-050465 HYDROCHLORIDE

Preferred Name

English

PARSACLISIB HYDROCHLORIDE

Official Name

English

(4R)-4-{3-[(1S)-1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl]-5-chloro-2-ethoxy-6-fluorophenyl}pyrrolidin-2-oneùhydrochloric acid (1:1)

Systematic Name

English

PARSACLISIB HYDROCHLORIDE [USAN]

Common Name

English

2-PYRROLIDINONE, 4-(3-((1S)-1-(4-AMINO-3-METHYL-1H-PYRAZOLO(3,4-D)PYRIMIDIN-1-YL)ETHYL)-5-CHLORO-2-ETHOXY-6-FLUOROPHENYL)-, HYDROCHLORIDE (1:1), (4R)-

Systematic Name

English

INCB050465 HYDROCHLORIDE

Common Name

English

PARSACLISIB HYDROCHLORIDE [JAN]

Common Name

English

Code System Code Type Description

USAN

FG-214