U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C39H49ClN4O2
Molecular Weight 641.285
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of GSK-1004723

SMILES

ClC1=CC=C(CC2=NN(C[C@H]3CCCN3CCCCC4=CC=C(OCCCN5CCCCCC5)C=C4)C(=O)C6=C2C=CC=C6)C=C1

InChI

InChIKey=YANGEESWIGIKOP-UUWRZZSWSA-N
InChI=1S/C39H49ClN4O2/c40-33-19-15-32(16-20-33)29-38-36-13-3-4-14-37(36)39(45)44(41-38)30-34-12-9-27-43(34)26-8-5-11-31-17-21-35(22-18-31)46-28-10-25-42-23-6-1-2-7-24-42/h3-4,13-22,34H,1-2,5-12,23-30H2/t34-/m1/s1

HIDE SMILES / InChI

Molecular Formula C39H49ClN4O2
Molecular Weight 641.285
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

GSK-1004723 is a dual histamine H(1) and H(3) receptor antagonist with a long duration of action that has been investigated for the treatment of allergic rhinitis. GSK-1004723 was designed for intranasal administration as a suspension or solution. Clinical trials (phase 1 and 2) showed that GSK-1004723 is well tolerated and demonstrates clinically significant attenuation of symptoms (tested in an environmental allergen challenge chamber). However, attenuation of symptoms was less than seen for treatment with cetirizine (a commonly used over-the-counter antihistamine).

Originator

Approval Year

Patents

Patents

Substance Class Chemical
Created
by admin
on Sat Dec 16 03:01:36 GMT 2023
Edited
by admin
on Sat Dec 16 03:01:36 GMT 2023
Record UNII
S08212J4ZR
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
GSK-1004723
Common Name English
GSK1004723
Code English
1(2H)-PHTHALAZINONE, 4-((4-CHLOROPHENYL)METHYL)-2-(((2R)-1-(4-(4-(3-(HEXAHYDRO-1H-AZEPIN-1-YL)PROPOXY)PHENYL)BUTYL)-2-PYRROLIDINYL)METHYL)-
Systematic Name English
Code System Code Type Description
CAS
955359-72-5
Created by admin on Sat Dec 16 03:01:36 GMT 2023 , Edited by admin on Sat Dec 16 03:01:36 GMT 2023
PRIMARY
DRUG BANK
DB12806
Created by admin on Sat Dec 16 03:01:36 GMT 2023 , Edited by admin on Sat Dec 16 03:01:36 GMT 2023
PRIMARY
PUBCHEM
17747460
Created by admin on Sat Dec 16 03:01:36 GMT 2023 , Edited by admin on Sat Dec 16 03:01:36 GMT 2023
PRIMARY
FDA UNII
S08212J4ZR
Created by admin on Sat Dec 16 03:01:36 GMT 2023 , Edited by admin on Sat Dec 16 03:01:36 GMT 2023
PRIMARY
Related Record Type Details
ACTIVE MOIETY