TAZEPROFEN

Details

Stereochemistry	RACEMIC
Molecular Formula	C16H13NO2S
Molecular Weight	283.345
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C(O)=O)C1=CC2=C(C=C1)N=C(S2)C3=CC=CC=C3

InChI

InChIKey=DPRKTNKWAXPYNW-UHFFFAOYSA-N

InChI=1S/C16H13NO2S/c1-10(16(18)19)12-7-8-13-14(9-12)20-15(17-13)11-5-3-2-4-6-11/h2-10H,1H3,(H,18,19)

HIDE SMILES / InChI

Molecular Formula	C16H13NO2S
Molecular Weight	283.345
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2889550 | https://www.ncbi.nlm.nih.gov/pubmed/2897197 | https://adisinsight.springer.com/drugs/800000037

Tazifylline (also known as LN 2974) is a long-acting histamine H1-receptor antagonist that was studied in clinical trials for the treatment of allergic rhinitis and asthma. In addition, this compound was studied on the itching and scratching of patients with atopic eczema. However, the further development of tazifylline appears to have been discontinued by Roche.

Originator

Approval Year

PubMed

Title	Date	PubMed
Multiple-dose pharmacokinetics of the new H1-receptor antagonist tazifylline in healthy volunteers.	1989-01-01	2564283
Antiallergic effects of the new histamine H1-receptor antagonist tazifylline in healthy atopic and non-atopic subjects.	1988-02	2897197
The effect of a new non-sedative H1-receptor antagonist (LN2974) on the itching and scratching of patients with atopic eczema.	1986-11	2889550
Animal pharmacology of the selective histamine H1-receptor antagonist tazifylline.	1986-04	2424463

Sample Use Guides

In Vivo Use Guide

10 mg b.i.d. for 8 days

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:33:00 GMT 2025` Edited by `admin` on `Mon Mar 31 18:33:00 GMT 2025`
Record UNII	S05RV1R3LZ
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

tazeprofen [INN]

Preferred Name

English

TAZEPROFEN

Official Name

English

Classification Tree Code System Code

NCI_THESAURUS

C257