BUDRALAZINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C14H16N4
Molecular Weight	240.3036
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)=CC(C)=NNC1=NN=CC2=C1C=CC=C2

InChI

InChIKey=DQGFCLJXYFXXIJ-LFIBNONCSA-N

InChI=1S/C14H16N4/c1-10(2)8-11(3)16-18-14-13-7-5-4-6-12(13)9-15-17-14/h4-9H,1-3H3,(H,17,18)/b16-11+

HIDE SMILES / InChI

Molecular Formula	C14H16N4
Molecular Weight	240.3036
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Description
Sources: https://books.google.ru/books?id=PghVgVDfF7UC&pg=PA316&lpg=PA316&dq=Buterazine+use&source=bl&ots=ecek3NMJTc&sig=PL9iCBDDaQG9C7pFXOO17hdGoZY&hl=en&sa=X&ved=0ahUKEwjt3dXMwonPAhXNOSwKHQUIBr0Q6AEIKTAD#v=onepage&q=Buterazine%20use&f=false Retrieved from Antihypertensive Drugs Today edited by Hideya Saito, Masaru Minami
Curator's Comment: Description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/3656776 and http://synapse.koreamed.org/DOIx.php?id=10.4070/kcj.1984.14.2.373

Budralazine is a vasodilator. Budralazine is a direct-acting vasodilating agent that does not produce marked tachycardia. Hypotensive effect of Buterazine has being shown. Budralazine is reported as an ingredient of Buterazine in Japan.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
adrenergic receptor signaling pathway 1 Target ID: GO:0071875 Sources: http://www.ncbi.nlm.nih.gov/pubmed/6268123	Modulator 828

Conditions

Condition	Modality	Targets	Highest Phase	Product
Hypertension 567 Sources: http://synapse.koreamed.org/DOIx.php?id=10.4070/kcj.1984.14.2.373	Primary		Approved 8429	Buterazine Approved Use Antihypertensive drug

PubMed

Title	Date	PubMed
Pre- and postsynaptic alpha-adrenergic effects of the antihypertensive drug budralazine.	1981	6268123

Patents

Sample Use Guides

In Vivo Use Guide

The initial dose should be 90-120 mg. The maintenance dosage is usually 90-180 mg. The maintenance dosage is usually 90-180 mg per day, given in two or three divided doses.

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:37:19 GMT 2023` Edited by `admin` on `Fri Dec 15 17:37:19 GMT 2023`
Record UNII	S0177QHV2B
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BUDRALAZINE

Official Name

English

Budralazine [WHO-DD]

Common Name

English

BUTERAZINE

Brand Name

English

budralazine [INN]

Common Name

English

BUDRALAZINE [MI]

Common Name

English

BUDRALAZINE [JAN]

Common Name

English

4-METHYL-3-PENTEN-2-ONE (1-PHTHALAZINYL)HYDRAZONE

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C270