Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C19H23N3O |
| Molecular Weight | 309.4054 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC1=CC(NC(=O)CN2CCC(CC2)C3=NC=CC=C3)=CC=C1
InChI
InChIKey=JFCDMGGMCUKHST-UHFFFAOYSA-N
InChI=1S/C19H23N3O/c1-15-5-4-6-17(13-15)21-19(23)14-22-11-8-16(9-12-22)18-7-2-3-10-20-18/h2-7,10,13,16H,8-9,11-12,14H2,1H3,(H,21,23)
| Molecular Formula | C19H23N3O |
| Molecular Weight | 309.4054 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
DescriptionCurator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/19020411
Curator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/19020411
A-412,997 or A-412997 is a highly selective agonist for the dopamine D4 receptor. In animal tests, it improved cognitive performance to a similar extent as methylphenidate, but without producing place preference or other signs of abuse liability. When dosed systemically, A-412997 crossed the blood brain barrier rapidly. It was suggested, that selective activation of the D4 receptor, A-412997, might represent a target for the treatment of attention deficit hyperactivity disorder without the potential drug abuse liability associated with current psychostimulant therapies.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| A-412997, a selective dopamine D4 agonist, improves cognitive performance in rats. | 2005 Sep |
|
| A-412997 is a selective dopamine D4 receptor agonist in rats. | 2005 Sep |
|
| Selective dopamine D4 receptor agonist (A-412997) improves cognitive performance and stimulates motor activity without influencing reward-related behaviour in rat. | 2008 Dec |
Patents
Sample Use Guides
rats: A-412997 (effective dose=0.1 micromol/kg, s.c.)
Route of Administration:
Other
In Vitro Use Guide
Curator's Comment: A-412997 is a highly selective dopamine D4 receptor agonist that binds with high affinity to rat dopamine D4 and human dopamine D4.4 receptors (Ki=12.1 and 7.9 nM, respectively). In contrast to the dopamine D4 receptor agonists PD168077 and CP226269, A-412997 showed a better selectivity profile and no affinity <1000 nM for other dopamine receptors or any other proteins in a panel of seventy different receptors and channels. In functional assays using calcium flux, A-412997 was a potent full agonist at rat dopamine D4 receptors (28.4 nM, intrinsic activity=0.83) and did not activate rat dopamine D2L receptors, unlike CP226269.
Unknown
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 08:34:43 UTC 2023
by
admin
on
Sat Dec 16 08:34:43 UTC 2023
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| Record UNII |
RWL9H93ARB
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| Record Status |
Validated (UNII)
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| Record Version |
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10425450
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A-412997
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DTXSID70212234
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RWL9H93ARB
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630116-49-3
Created by
admin on Sat Dec 16 08:34:43 UTC 2023 , Edited by admin on Sat Dec 16 08:34:43 UTC 2023
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ACTIVE MOIETY |
