LH-846

Details

Stereochemistry	ACHIRAL
Molecular Formula	C16H13ClN2OS
Molecular Weight	316.805
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=CC2=C(C=C1Cl)N=C(NC(=O)CC3=CC=CC=C3)S2

InChI

InChIKey=DYHAMRNAHTWYKY-UHFFFAOYSA-N

InChI=1S/C16H13ClN2OS/c1-10-7-14-13(9-12(10)17)18-16(21-14)19-15(20)8-11-5-3-2-4-6-11/h2-7,9H,8H2,1H3,(H,18,19,20)

HIDE SMILES / InChI

Molecular Formula	C16H13ClN2OS
Molecular Weight	316.805
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/21954091

LH846 targets casein kinase 1δ activity. It is able to regulate circadian rhythms.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Casein kinase I delta 4 Target ID: CHEMBL2828 Sources: https://www.ncbi.nlm.nih.gov/pubmed/21954091	Inhibitor 8504		290.0 nM [IC50]

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2596

PubMed

Title	Date	PubMed
A small molecule modulates circadian rhythms through phosphorylation of the period protein.	2011-11-04	21954091

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

The benzothiazole derivative LH846 (8 μM) lengthened the period (10 h) with minimal effect on the amplitude of both Per2-dLuc and Bmal1-dLuc rhythms in U2OS cells

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:33:10 GMT 2025` Edited by `admin` on `Mon Mar 31 18:33:10 GMT 2025`
Record UNII	RW5ZBU2L6P
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

N-(5-CHLORO-6-METHYL-2-BENZOTHIAZOLYL)BENZENEACETAMIDE

Preferred Name

English

LH-846

Common Name

English

BENZENEACETAMIDE, N-(5-CHLORO-6-METHYL-2-BENZOTHIAZOLYL)-

Systematic Name

English

LH846

Code

English

Code System Code Type Description

PUBCHEM

851474

Created by admin on Mon Mar 31 18:33:10 GMT 2025 , Edited by admin on Mon Mar 31 18:33:10 GMT 2025

PRIMARY

CAS

639052-78-1

Created by admin on Mon Mar 31 18:33:10 GMT 2025 , Edited by admin on Mon Mar 31 18:33:10 GMT 2025

PRIMARY

FDA UNII

RW5ZBU2L6P

Created by admin on Mon Mar 31 18:33:10 GMT 2025 , Edited by admin on Mon Mar 31 18:33:10 GMT 2025

PRIMARY

Related Record Type Details


					RW5ZBU2L6P

LH-846

ACTIVE MOIETY

Amount:

Details

SMILES

InChI

DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/21954091

Originator

Approval Year

Targets

Conditions

PubMed

Sample Use Guides

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/21954091