MALOTILATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C12H16O4S2
Molecular Weight	288.383
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)OC(=O)C(C(=O)OC(C)C)=C1SC=CS1

InChI

InChIKey=YPIQVCUJEKAZCP-UHFFFAOYSA-N

InChI=1S/C12H16O4S2/c1-7(2)15-10(13)9(11(14)16-8(3)4)12-17-5-6-18-12/h5-8H,1-4H3

HIDE SMILES / InChI

Molecular Formula	C12H16O4S2
Molecular Weight	288.383
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.ncbi.nlm.nih.gov/pubmed/2544209
Curator's Comment: description was created based on several sources, including https://www.medchemexpress.com/malotilate.html

Malotilate (NKK-105) is a drug used in the treatment of liver disease. Malotilate selectively inhibits the 5-lipoxygenase. Malotilate prevented increases in serum markers of type III and IV collagen synthesis as well as accumulation of the collagens, laminin and fibronectin in the liver.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Arachidonate 5-lipoxygenase 49 Target ID: CHEMBL215 Sources: http://www.ncbi.nlm.nih.gov/pubmed/2537738	Inhibitor 8297

Conditions

Condition	Modality	Targets	Highest Phase	Product
Alcoholic liver disease 2 Sources: http://www.ncbi.nlm.nih.gov/pubmed/2544209	Primary		Phase II 1132	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
[Protective effect of malotilate (diisopropyl 1,3-dithiol-2-ylidenemalonate) on chemical-induced hepatotoxicity].	1986 Aug	3795300
Modulation of the reductive metabolism of halothane by microsomal cytochrome b5 in rat liver.	1987 Dec 7	3689822
[Acute alcoholic hepatitis: treatments].	2001 Jun 9	11433695
Serum levels of YKL-40 and PIIINP as prognostic markers in patients with alcoholic liver disease.	2003 Aug	12873813
Matrix metalloproteinase gene delivery for liver fibrosis.	2008 Feb	17577645

Patents

Sample Use Guides

In Vivo Use Guide

Six patients in an open 6-month trial received malotilate 200 mg t.i.d. for 2 months and 400 mg t.i.d. for 4 months

Route of Administration: Oral

In Vitro Use Guide

Effects of NKK-105 (MALOTILATE) against lipid peroxidation of microsomes by CCl4 are investigated, in vitro. NKK-105 had no effect on microsomal lipid peroxidation. With the microsomal fraction was preincubated with NKK-105 before adding CCl4, the lipid peroxidation induced with CCl4 was almost prevented by NKK-105.

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:52:53 GMT 2023` Edited by `admin` on `Fri Dec 15 17:52:53 GMT 2023`
Record UNII	RV59PND975
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

MALOTILATE

Official Name

English

KANTEC

Brand Name

English

MALOTILATE [MART.]

Common Name

English

PROPANEDIOIC ACID, 2-(1,3-DITHIOL-2-YLIDENE)-, 1,3-BIS(1-METHYLETHYL) ESTER

Common Name

English

HEPATION

Brand Name

English

NKK-105

Code

English

MALOTILATE [MI]

Common Name

English

PROPANEDIOIC ACID, 1,3-DITHIOL-2-YLIDENE-, BIS(1-METHYLETHYL) ESTER

Common Name

English

MALOTILATE [JAN]

Common Name

English

malotilate [INN]

Common Name

English

Malotilate [WHO-DD]

Common Name

English

MALOTILATE [USAN]

Common Name

English

DIISOPROPYL 1,3-DITHIOL-2-YLIDENEMALONATE

Systematic Name

English

NKK 105

Code

English

Code System Code Type Description

SMS_ID

100000081740