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Details

Stereochemistry ACHIRAL
Molecular Formula C8H17NO
Molecular Weight 143.2267
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of VALPROMIDE

SMILES

CCCC(CCC)C(N)=O

InChI

InChIKey=OMOMUFTZPTXCHP-UHFFFAOYSA-N
InChI=1S/C8H17NO/c1-3-5-7(6-4-2)8(9)10/h7H,3-6H2,1-2H3,(H2,9,10)

HIDE SMILES / InChI

Molecular Formula C8H17NO
Molecular Weight 143.2267
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Valpromide (2-propylpentanamide) is a derivative of valproic acid. Bio-pharmacological data show several possible mechanisms of action involving an increase in GABA levels in brain as well as changes in membrane conductance on neurons. Valpromide has been shown to decrease aggressivity in stress-induced animals, to regulate anxious induced behaviours, as well as to potentiate central sedative compounds. It produces a significant increase of cognitive functions. Psychopathological experiments have shown: a wakening of personality, euphoric effects, an improvement of social behaviour, a stabilization of mood in affective disorders. Valpromide is indicated for the treatment of bipolar disorder (manic episodes). It is marketed in some Europe countries.

CNS Activity

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
DEPAMIDE

PubMed

Sample Use Guides

In Vivo Use Guide
Recommended initial dose 750 mg per day
Route of Administration: Oral
In Vitro Use Guide
1 mM valpromide affects epileptiform activities of neuron B3 of buccal ganglia of Helix pomatia
Substance Class Chemical
Record UNII
RUA6CWU76G
Record Status Validated (UNII)
Record Version