MECLONAZEPAM

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C16H12ClN3O3
Molecular Weight	329.738
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C[C@@H]1N=C(C2=CC=CC=C2Cl)C3=CC(=CC=C3NC1=O)[N+]([O-])=O

InChI

InChIKey=LMUVYJCAFWGNSY-VIFPVBQESA-N

InChI=1S/C16H12ClN3O3/c1-9-16(21)19-14-7-6-10(20(22)23)8-12(14)15(18-9)11-4-2-3-5-13(11)17/h2-9H,1H3,(H,19,21)/t9-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C16H12ClN3O3
Molecular Weight	329.738
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/3931136 | https://www.ncbi.nlm.nih.gov/pubmed/17767796 | https://www.ncbi.nlm.nih.gov/pubmed/19374857

Meclonazepam (Ro11-3128 or 3-methylclonazepam) is a benzodiazepine derivative. It exerts anxiolytic activity. Meclonazepam demonstrated anti-schistosomal action, it causes spastic paralysis, calcium influx and tegumental disruption in the parasites. Contracturant effect of meclonazepam is not a result of its binding to the worm benzodiazepine binding sites.

CNS Activity

Approval Year

PubMed

Title	Date	PubMed
Meclonazepam analogues as potential new antihelmintic agents.	2008 Apr 1	18343662
Praziquantel and the benzodiazepine Ro 11-3128 do not compete for the same binding sites in schistosomes.	2008 Jan	17767796
The effects of 3-methylclonazepam on Schistosoma mansoni musculature are not mediated by benzodiazepine receptors.	2009 Mar 15	19374857
Comparison of microscopy and Alamar blue reduction in a larval based assay for schistosome drug screening.	2010 Aug 10	20706580

Patents

Sample Use Guides

In Vivo Use Guide

Initial study of meclonazepam in generalized anxiety disorder. Daily dosage was flexible, from three to six tablets of meclonazepam 1 mg

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:59:19 GMT 2023` Edited by `admin` on `Fri Dec 15 16:59:19 GMT 2023`
Record UNII	RN43209SMA
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

MECLONAZEPAM

Official Name

English

5-(2-chlorophenyl)-3-methyl-7-nitro-2,3-dihydro-1H-1,4-benzodiazepin-2-one

Systematic Name

English

RO 11-3128/002

Common Name

English

meclonazepam [INN]

Common Name

English

2H-1,4-BENZODIAZEPIN-2-ONE, 5-(2-CHLOROPHENYL)-1,3-DIHYDRO-3-METHYL-7-NITRO-, (3S)-

Systematic Name

English

Ro 11-3128

Common Name

English

(+)-(S)-5-(O-CHLOROPHENYL)-1,3-DIHYDRO-3-METHYL-7-NITRO-2H-1,4-BENZODIAZEPIN-2-ONE

Common Name

English

Meclonazepam [NFLIS-DRUG]

Common Name

English

Classification Tree Code System Code

WIKIPEDIA

Designer-drugs-Meclonazepam