MECLONAZEPAM

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C16H12ClN3O3
Molecular Weight	329.738
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C[C@@H]1N=C(C2=C(Cl)C=CC=C2)C3=C(NC1=O)C=CC(=C3)[N+]([O-])=O

InChI

InChIKey=LMUVYJCAFWGNSY-VIFPVBQESA-N

InChI=1S/C16H12ClN3O3/c1-9-16(21)19-14-7-6-10(20(22)23)8-12(14)15(18-9)11-4-2-3-5-13(11)17/h2-9H,1H3,(H,19,21)/t9-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C16H12ClN3O3
Molecular Weight	329.738
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/3931136 | https://www.ncbi.nlm.nih.gov/pubmed/17767796 | https://www.ncbi.nlm.nih.gov/pubmed/19374857

Meclonazepam (Ro11-3128 or 3-methylclonazepam) is a benzodiazepine derivative. It exerts anxiolytic activity. Meclonazepam demonstrated anti-schistosomal action, it causes spastic paralysis, calcium influx and tegumental disruption in the parasites. Contracturant effect of meclonazepam is not a result of its binding to the worm benzodiazepine binding sites.

CNS Activity

Approval Year

PubMed

Title	Date	PubMed
Comparison of microscopy and Alamar blue reduction in a larval based assay for schistosome drug screening.	2010-08-10	20706580
The effects of 3-methylclonazepam on Schistosoma mansoni musculature are not mediated by benzodiazepine receptors.	2009-03-15	19374857
Schistosoma mansoni: lack of correlation between praziquantel-induced intra-worm calcium influx and parasite death.	2008-07	18456260
Meclonazepam analogues as potential new antihelmintic agents.	2008-04-01	18343662
Praziquantel and the benzodiazepine Ro 11-3128 do not compete for the same binding sites in schistosomes.	2008-01	17767796
The anti-schistosomal drug praziquantel is an adenosine antagonist.	2007-08	17428352

Patents

Sample Use Guides

In Vivo Use Guide

Initial study of meclonazepam in generalized anxiety disorder. Daily dosage was flexible, from three to six tablets of meclonazepam 1 mg

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:38:56 GMT 2025` Edited by `admin` on `Mon Mar 31 18:38:56 GMT 2025`
Record UNII	RN43209SMA
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

MECLONAZEPAM

Official Name

English

(+)-(S)-5-(O-CHLOROPHENYL)-1,3-DIHYDRO-3-METHYL-7-NITRO-2H-1,4-BENZODIAZEPIN-2-ONE

Preferred Name

English

5-(2-chlorophenyl)-3-methyl-7-nitro-2,3-dihydro-1H-1,4-benzodiazepin-2-one

Systematic Name

English

RO 11-3128/002

Common Name

English

meclonazepam [INN]

Common Name

English

2H-1,4-BENZODIAZEPIN-2-ONE, 5-(2-CHLOROPHENYL)-1,3-DIHYDRO-3-METHYL-7-NITRO-, (3S)-

Systematic Name

English

Ro 11-3128

Common Name

English

Meclonazepam [NFLIS-DRUG]

Common Name

English

Classification Tree Code System Code

WIKIPEDIA

Designer-drugs-Meclonazepam