U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C25H30N2O5
Molecular Weight 438.5161
Optical Activity UNSPECIFIED
Defined Stereocenters 3 / 3
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of QUINAPRIL

SMILES

CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@@H](C)C(=O)N2CC3=C(C[C@H]2C(O)=O)C=CC=C3

InChI

InChIKey=JSDRRTOADPPCHY-HSQYWUDLSA-N
InChI=1S/C25H30N2O5/c1-3-32-25(31)21(14-13-18-9-5-4-6-10-18)26-17(2)23(28)27-16-20-12-8-7-11-19(20)15-22(27)24(29)30/h4-12,17,21-22,26H,3,13-16H2,1-2H3,(H,29,30)/t17-,21-,22-/m0/s1

HIDE SMILES / InChI

Molecular Formula C25H30N2O5
Molecular Weight 438.5161
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 3 / 3
E/Z Centers 0
Optical Activity UNSPECIFIED

Description
Curator's Comment: description was created based on several sources, including https://clinicaltrials.gov/ct2/show/NCT00651287 | https://www.ncbi.nlm.nih.gov/pubmed/25922179 | https://www.ncbi.nlm.nih.gov/pubmed/1691409

Quinapril is the hydrochloride salt of quinapril, the ethyl ester of a non-sulfhydryl, angiotensin-converting enzyme (ACE) inhibitor, quinaprilat. Quinapril hydrochloride is a white to off-white amorphous powder that is freely soluble in aqueous solvents. Quinapril is indicated for the treatment of high blood pressure (hypertension) and as adjunctive therapy in the management of heart failure. It may be used for the treatment of hypertension by itself or in combination with thiazide diuretics, and with diuretics and digoxin for heart failure.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
2.8 nM [IC50]
110.0 nM [IC50]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
ACCURETIC

Approved Use

INDICATIONS AND USA. Hypertension: ACCURETIC is indicated for the treatment of hypertension, to lower blood pressure. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions. These benefits have been seen in controlled trials of antihypertensive drugs from a wide variety of pharmacologic classes including the class to which this drug principally belongs. There are no controlled trials demonstrating risk reduction with ACCURETIC. Control of high blood pressure should be part of comprehensive cardiovascular risk management, including, as appropriate, lipid control, diabetes management, antithrombotic therapy, smoking cessation, exercise, and limited sodium intake. Many patients will require more than one drug to achieve blood pressure goals. For specific advice on goals and management, see published guidelines, such as those of the National High Blood Pressure Education Program’s Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC). Numerous antihypertensive drugs, from a variety of pharmacologic classes and with different mechanisms of action, have been shown in randomized controlled trials to reduce cardiovascular morbidity and mortality, and it can be concluded that it is blood pressure reduction, and not some other pharmacologic property of the drugs, that is largely responsible for those benefits. The largest and most consistent cardiovascular outcome benefit has been a reduction in the risk of stroke, but reductions in myocardial infarction and cardiovascular mortality also have been seen regularly. 6 Reference ID: 3818285 Elevated systolic or diastolic pressure causes increased cardiovascular risk, and the absolute risk increase per mmHg is greater at higher blood pressures, so that even modest reductions of severe hypertension can provide substantial benefit. Relative risk reduction from blood pressure reduction is similar across populations with varying absolute risk, so the absolute benefit is greater in patients who are at higher risk independent of their hypertension (for example, patients with diabetes or hyperlipidemia), and such patients would be expected to benefit from more aggressive treatment to a lower blood pressure goal. Some antihypertensive drugs have smaller blood pressure effects (as monotherapy) in black patients, and many antihypertensive drugs have additional approved indications and effects (e.g., on angina, heart failure, or diabetic kidney disease). These considerations may guide selection of therapy. This fixed combination is not indicated for the initial therapy of hypertension (see DOSAGE AND ADMINISTRATION). In using ACCURETIC, consideration should be given to the fact that another angiotensinconverting enzyme inhibitor, captopril, has caused agranulocytosis, particularly in patients with renal impairment or collagen-vascular disease. Available data are insufficient to show that quinapril does not have a similar risk (see WARNINGS: Neutropenia/Agranulocytosis). Angioedema in Black Patients: Black patients receiving ACE inhibitor monotherapy have been reported to have a higher incidence of angioedema compared to non-blacks. It should also be noted that in controlled clinical trials, ACE inhibitors have an effect on blood pressure that is less in black patients than in non-blacks.

Launch Date

9.4625281E11
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
1526 ng/mL
10 mg single, intravenous
dose: 10 mg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
QUINAPRILAT plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FASTED
345 ng/mL
2.5 mg single, intravenous
dose: 2.5 mg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
QUINAPRILAT plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FASTED
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
1706 μg × h/L
10 mg 2 times / day steady-state, oral
dose: 10 mg
route of administration: Oral
experiment type: STEADY-STATE
co-administered:
QUINAPRILAT plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
2670 ng × h/mL
10 mg single, intravenous
dose: 10 mg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
QUINAPRILAT plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FASTED
580 ng × h/mL
2.5 mg single, intravenous
dose: 2.5 mg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
QUINAPRILAT plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FASTED
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
3.7 h
10 mg 2 times / day steady-state, oral
dose: 10 mg
route of administration: Oral
experiment type: STEADY-STATE
co-administered:
QUINAPRILAT plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
2.29 h
10 mg single, intravenous
dose: 10 mg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
QUINAPRILAT plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FASTED
2.26 h
2.5 mg single, intravenous
dose: 2.5 mg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
QUINAPRILAT plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FASTED
Doses

Doses

DosePopulationAdverse events​
40 mg 1 times / day multiple, oral (max)
Recommended
Dose: 40 mg, 1 times / day
Route: oral
Route: multiple
Dose: 40 mg, 1 times / day
Sources: Page: 11
unhealthy, adult
n = 1563
Health Status: unhealthy
Condition: Hypertension
Age Group: adult
Sex: M+F
Population Size: 1563
Sources: Page: 11
Disc. AE: Headache, Dizziness...
AEs leading to
discontinuation/dose reduction:
Headache (0.7%)
Dizziness (0.8%)
Fatigue (0.3%)
Coughing (0.5%)
Nausea and vomiting (0.3%)
Abdominal pain (0.2%)
Sources: Page: 11
40 mg 1 times / day multiple, oral (max)
Recommended
Dose: 40 mg, 1 times / day
Route: oral
Route: multiple
Dose: 40 mg, 1 times / day
Sources: Page: 12
unhealthy, adult
n = 585
Health Status: unhealthy
Condition: Hypertension
Age Group: adult
Sex: M+F
Population Size: 585
Sources: Page: 12
Disc. AE: Dizziness, Coughing...
AEs leading to
discontinuation/dose reduction:
Dizziness (0.7%)
Coughing (0.3%)
Fatigue (0.2%)
Nausea and vomiting (0.2%)
Hypotension (0.5%)
Dyspnea (0.2%)
Rash (0.2%)
Sources: Page: 12
AEs

AEs

AESignificanceDosePopulation
Abdominal pain 0.2%
Disc. AE
40 mg 1 times / day multiple, oral (max)
Recommended
Dose: 40 mg, 1 times / day
Route: oral
Route: multiple
Dose: 40 mg, 1 times / day
Sources: Page: 11
unhealthy, adult
n = 1563
Health Status: unhealthy
Condition: Hypertension
Age Group: adult
Sex: M+F
Population Size: 1563
Sources: Page: 11
Fatigue 0.3%
Disc. AE
40 mg 1 times / day multiple, oral (max)
Recommended
Dose: 40 mg, 1 times / day
Route: oral
Route: multiple
Dose: 40 mg, 1 times / day
Sources: Page: 11
unhealthy, adult
n = 1563
Health Status: unhealthy
Condition: Hypertension
Age Group: adult
Sex: M+F
Population Size: 1563
Sources: Page: 11
Nausea and vomiting 0.3%
Disc. AE
40 mg 1 times / day multiple, oral (max)
Recommended
Dose: 40 mg, 1 times / day
Route: oral
Route: multiple
Dose: 40 mg, 1 times / day
Sources: Page: 11
unhealthy, adult
n = 1563
Health Status: unhealthy
Condition: Hypertension
Age Group: adult
Sex: M+F
Population Size: 1563
Sources: Page: 11
Coughing 0.5%
Disc. AE
40 mg 1 times / day multiple, oral (max)
Recommended
Dose: 40 mg, 1 times / day
Route: oral
Route: multiple
Dose: 40 mg, 1 times / day
Sources: Page: 11
unhealthy, adult
n = 1563
Health Status: unhealthy
Condition: Hypertension
Age Group: adult
Sex: M+F
Population Size: 1563
Sources: Page: 11
Headache 0.7%
Disc. AE
40 mg 1 times / day multiple, oral (max)
Recommended
Dose: 40 mg, 1 times / day
Route: oral
Route: multiple
Dose: 40 mg, 1 times / day
Sources: Page: 11
unhealthy, adult
n = 1563
Health Status: unhealthy
Condition: Hypertension
Age Group: adult
Sex: M+F
Population Size: 1563
Sources: Page: 11
Dizziness 0.8%
Disc. AE
40 mg 1 times / day multiple, oral (max)
Recommended
Dose: 40 mg, 1 times / day
Route: oral
Route: multiple
Dose: 40 mg, 1 times / day
Sources: Page: 11
unhealthy, adult
n = 1563
Health Status: unhealthy
Condition: Hypertension
Age Group: adult
Sex: M+F
Population Size: 1563
Sources: Page: 11
Dyspnea 0.2%
Disc. AE
40 mg 1 times / day multiple, oral (max)
Recommended
Dose: 40 mg, 1 times / day
Route: oral
Route: multiple
Dose: 40 mg, 1 times / day
Sources: Page: 12
unhealthy, adult
n = 585
Health Status: unhealthy
Condition: Hypertension
Age Group: adult
Sex: M+F
Population Size: 585
Sources: Page: 12
Fatigue 0.2%
Disc. AE
40 mg 1 times / day multiple, oral (max)
Recommended
Dose: 40 mg, 1 times / day
Route: oral
Route: multiple
Dose: 40 mg, 1 times / day
Sources: Page: 12
unhealthy, adult
n = 585
Health Status: unhealthy
Condition: Hypertension
Age Group: adult
Sex: M+F
Population Size: 585
Sources: Page: 12
Nausea and vomiting 0.2%
Disc. AE
40 mg 1 times / day multiple, oral (max)
Recommended
Dose: 40 mg, 1 times / day
Route: oral
Route: multiple
Dose: 40 mg, 1 times / day
Sources: Page: 12
unhealthy, adult
n = 585
Health Status: unhealthy
Condition: Hypertension
Age Group: adult
Sex: M+F
Population Size: 585
Sources: Page: 12
Rash 0.2%
Disc. AE
40 mg 1 times / day multiple, oral (max)
Recommended
Dose: 40 mg, 1 times / day
Route: oral
Route: multiple
Dose: 40 mg, 1 times / day
Sources: Page: 12
unhealthy, adult
n = 585
Health Status: unhealthy
Condition: Hypertension
Age Group: adult
Sex: M+F
Population Size: 585
Sources: Page: 12
Coughing 0.3%
Disc. AE
40 mg 1 times / day multiple, oral (max)
Recommended
Dose: 40 mg, 1 times / day
Route: oral
Route: multiple
Dose: 40 mg, 1 times / day
Sources: Page: 12
unhealthy, adult
n = 585
Health Status: unhealthy
Condition: Hypertension
Age Group: adult
Sex: M+F
Population Size: 585
Sources: Page: 12
Hypotension 0.5%
Disc. AE
40 mg 1 times / day multiple, oral (max)
Recommended
Dose: 40 mg, 1 times / day
Route: oral
Route: multiple
Dose: 40 mg, 1 times / day
Sources: Page: 12
unhealthy, adult
n = 585
Health Status: unhealthy
Condition: Hypertension
Age Group: adult
Sex: M+F
Population Size: 585
Sources: Page: 12
Dizziness 0.7%
Disc. AE
40 mg 1 times / day multiple, oral (max)
Recommended
Dose: 40 mg, 1 times / day
Route: oral
Route: multiple
Dose: 40 mg, 1 times / day
Sources: Page: 12
unhealthy, adult
n = 585
Health Status: unhealthy
Condition: Hypertension
Age Group: adult
Sex: M+F
Population Size: 585
Sources: Page: 12
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG

OverviewOther

Other InhibitorOther SubstrateOther Inducer




Drug as perpetrator​

Drug as perpetrator​

TargetModalityActivityMetaboliteClinical evidence
yes [IC50 6.2 uM]
Drug as victim
PubMed

PubMed

TitleDatePubMed
Preservation of cardiac function and energy reserve by the angiotensin-converting enzyme inhibitor quinapril during postmyocardial infarction remodeling in the rat.
2001
Comparison of endothelial pleiotropic actions of angiotensin converting enzyme inhibitors and statins.
2001 Dec
Beneficial effect of quinapril in patients with angiotensin-converting enzyme D allele after coronary stenting.
2001 Dec
Quinapril with high affinity to tissue angiotensin-converting enzyme reduces restenosis after percutaneous transcatheter coronary intervention.
2001 Jul
Angiotensin converting enzyme inhibitors and restenosis: let's stop teasing ourselves.
2001 Jul
The influence of angiotensin-converting enzyme inhibitors on the aorta elastin metabolism in diet-induced hypercholesterolaemia in rabbits.
2001 Mar
[Quality of life and psychosocial factors during treatment with antihypertensive drugs. A comparison of captopril and quinapril in geriatric patients].
2001 Nov
Inhibition of progression of heart failure and expression of TGF-beta 1 mRNA in rats with heart failure by the ACE inhibitor quinapril.
2001 Oct
[Clinical sequelae of tissue angiotensin converting enzyme inhibition: practicability of use in ischemic heart disease].
2002
Clinical pharmacokinetics and selective pharmacodynamics of new angiotensin converting enzyme inhibitors: an update.
2002
Angiotensin II induced inflammation in the kidney and in the heart of double transgenic rats.
2002
Quinapril: a further update of its pharmacology and therapeutic use in cardiovascular disorders.
2002
Rapid increase in cardiac adrenomedullin gene expression caused by acute pressure overload: effect of the renin-angiotensin system on gene expression.
2002 Apr
Quinapril prevents restenosis after coronary stenting in patients with angiotensin-converting enzyme D allele.
2002 Apr
Inhibition of left ventricular fibrosis by tranilast in rats with renovascular hypertension.
2002 Apr
[Is mild essential hypertension without obvious organ complications and risk factors associated with increased levels of circulating markers of endothelial dysfunction? Effect of ACE inhibitor therapy].
2002 Aug
Circulating intercellular cell adhesion molecule-1, endothelin-1 and von Willebrand factor-markers of endothelial dysfunction in uncomplicated essential hypertension: the effect of treatment with ACE inhibitors.
2002 Aug
Enalapril and quinapril improve endothelial vasodilator function and aortic eNOS gene expression in L-NAME-treated rats.
2002 Aug 16
The ACE inhibitor, quinapril, ameliorates peritoneal fibrosis in an encapsulating peritoneal sclerosis model in mice.
2002 Dec
Effects of antihypertensive drugs in experimental type 2 diabetes-related nephropathy.
2002 Dec
Angiotensin II regulates the synthesis of proinflammatory cytokines and chemokines in the kidney.
2002 Dec
Influence of angiotensinogen M253T gene polymorphism and an angiotensin converting enzyme inhibitor on restenosis after percutaneous coronary intervention.
2002 Feb
Effects of chronic administration of sarpogrelate on systolic blood pressure of spontaneously hypertensive rats: comparison with quinapril.
2002 Feb
Angiotensin II as an inflammatory mediator: evolving concepts in the role of the renin angiotensin system in the failing heart.
2002 Jan
Effects of quinapril on myocardial function, ventricular remodeling and cardiac cytokine expression in congestive heart failure in the rat.
2002 Jan
Effects of a citrate buffer system on the solid-state chemical stability of lyophilized quinapril preparations.
2002 Jan
Determination of the angiotensin-converting enzyme inhibitor quinapril and its metabolite quinaprilat in pharmaceuticals and urine by capillary zone electrophoresis and solid-phase extraction.
2002 Jan
Oxidative stress and nitric oxide synthase in rat diabetic nephropathy: effects of ACEI and ARB.
2002 Jan
The solid-state stability of amorphous quinapril in the presence of beta-cyclodextrins.
2002 Jan
Simultaneous determination of quinapril and its active metabolite quinaprilat in human plasma using high-performance liquid chromatography with ultraviolet detection.
2002 Jan 25
Psychological characteristics and responses to antihypertensive drug therapy.
2002 Jan-Feb
The mechanism of the angiotensin-converting enzyme inhibitor quinapril is not related to bradykinin level in heart tissue.
2002 Jun
Subacute and chronic effects of quinapril on cardiac cytokine expression, remodeling, and function after myocardial infarction in the rat.
2002 Jun
Blockade of endothelial enzymes: new therapeutic targets.
2002 Mar
Ventricular remodeling after myocardial infarction and effects of ACE inhibition on hemodynamics and scar formation in SHR.
2002 Mar-Apr
Pretreatment with angiotensin-converting enzyme inhibitors attenuates ischemia-reperfusion injury.
2002 May
Bradykinin as a major endogenous regulator of endothelial function.
2002 May-Jun
Quinapril treatment restores the vasodilator action of insulin in fructose-hypertensive rats.
2002 May-Jun
Ischemia Management with Accupril post bypass Graft via Inhibition of angiotensin coNverting enzyme (IMAGINE): a multicentre randomized trial - design and rationale.
2002 Nov
Effect of losartan on nocturnal blood pressure in patients with stroke: comparison with angiotensin converting enzyme inhibitor.
2002 Nov
Optimisation by experimental design of a capillary electrophoretic method for the separation of several inhibitors of angiotensin-converting enzyme using alkylsulphonates.
2002 Nov 29
Captopril and quinapril reduce reactive oxygen species.
2002 Oct
[Angiotensin-converting enzyme, quinapril, in treating chronic cardiac failure].
2003
Effect of combination therapy with dipyridamole and quinapril in diabetic nephropathy.
2003 Feb
Comparative effects of angiotensin II receptor blockade (candesartan) with angiotensin-converting enzyme inhibitor (quinapril) in rats with dilated cardiomyopathy.
2003 Jan
Attenuation of heart failure due to coronary stenosis by ACE inhibitor and angiotensin receptor blocker.
2003 Jul
Square wave voltammetric determination of the angiotensin-converting enzyme inhibitors cilazapril, quinapril and ramipril in pharmaceutical formulations.
2003 May
Usefulness of quinapril and irbesartan to improve the anti-inflammatory response of atorvastatin and aspirin in patients with coronary heart disease.
2003 May 1
In vitro study on binding interaction of quinapril with bovine serum albumin (BSA) using multi-spectroscopic and molecular docking methods.
2017 Aug
Genetic variants associated with angiotensin-converting enzyme inhibitor-induced cough: a genome-wide association study in a Swedish population.
2017 Feb
Patents

Sample Use Guides

The recommended initial dosage of ACCUPRIL in patients not on diuretics is 10 or 20 mg once daily. Dosage should be adjusted according to blood pressure response measured at peak (2–6 hours after dosing) and trough (predosing). Generally, dosage adjustments should be made at intervals of at least 2 weeks. Most patients have required dosages of 20, 40, or 80 mg/day, given as a single dose or in two equally divided doses.
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Fri Dec 16 18:05:16 UTC 2022
Edited
by admin
on Fri Dec 16 18:05:16 UTC 2022
Record UNII
RJ84Y44811
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
QUINAPRIL
INN   MI   USP   VANDF   WHO-DD  
INN  
Official Name English
quinapril [INN]
Common Name English
QUINAPRIL [VANDF]
Common Name English
Quinapril [WHO-DD]
Common Name English
QUINAPRIL [USP IMPURITY]
Common Name English
QUINAPRIL [MI]
Common Name English
C09AA06
Code English
Classification Tree Code System Code
NDF-RT N0000175562
Created by admin on Fri Dec 16 18:05:17 UTC 2022 , Edited by admin on Fri Dec 16 18:05:17 UTC 2022
NDF-RT N0000000181
Created by admin on Fri Dec 16 18:05:17 UTC 2022 , Edited by admin on Fri Dec 16 18:05:17 UTC 2022
WHO-VATC QC09BA06
Created by admin on Fri Dec 16 18:05:17 UTC 2022 , Edited by admin on Fri Dec 16 18:05:17 UTC 2022
WHO-ATC C09BA06
Created by admin on Fri Dec 16 18:05:17 UTC 2022 , Edited by admin on Fri Dec 16 18:05:17 UTC 2022
NCI_THESAURUS C247
Created by admin on Fri Dec 16 18:05:17 UTC 2022 , Edited by admin on Fri Dec 16 18:05:17 UTC 2022
WHO-VATC QC09AA06
Created by admin on Fri Dec 16 18:05:17 UTC 2022 , Edited by admin on Fri Dec 16 18:05:17 UTC 2022
WHO-ATC C09AA06
Created by admin on Fri Dec 16 18:05:17 UTC 2022 , Edited by admin on Fri Dec 16 18:05:17 UTC 2022
LIVERTOX NBK548451
Created by admin on Fri Dec 16 18:05:17 UTC 2022 , Edited by admin on Fri Dec 16 18:05:17 UTC 2022
Code System Code Type Description
LACTMED
Quinapril
Created by admin on Fri Dec 16 18:05:17 UTC 2022 , Edited by admin on Fri Dec 16 18:05:17 UTC 2022
PRIMARY
RXCUI
35208
Created by admin on Fri Dec 16 18:05:17 UTC 2022 , Edited by admin on Fri Dec 16 18:05:17 UTC 2022
PRIMARY RxNorm
IUPHAR
6350
Created by admin on Fri Dec 16 18:05:17 UTC 2022 , Edited by admin on Fri Dec 16 18:05:17 UTC 2022
PRIMARY
DRUG CENTRAL
2340
Created by admin on Fri Dec 16 18:05:17 UTC 2022 , Edited by admin on Fri Dec 16 18:05:17 UTC 2022
PRIMARY
EVMPD
SUB10201MIG
Created by admin on Fri Dec 16 18:05:17 UTC 2022 , Edited by admin on Fri Dec 16 18:05:17 UTC 2022
PRIMARY
DRUG BANK
DB00881
Created by admin on Fri Dec 16 18:05:17 UTC 2022 , Edited by admin on Fri Dec 16 18:05:17 UTC 2022
PRIMARY
ChEMBL
CHEMBL1592
Created by admin on Fri Dec 16 18:05:17 UTC 2022 , Edited by admin on Fri Dec 16 18:05:17 UTC 2022
PRIMARY
WIKIPEDIA
QUINAPRIL
Created by admin on Fri Dec 16 18:05:17 UTC 2022 , Edited by admin on Fri Dec 16 18:05:17 UTC 2022
PRIMARY
PUBCHEM
54892
Created by admin on Fri Dec 16 18:05:17 UTC 2022 , Edited by admin on Fri Dec 16 18:05:17 UTC 2022
PRIMARY
MERCK INDEX
M9437
Created by admin on Fri Dec 16 18:05:17 UTC 2022 , Edited by admin on Fri Dec 16 18:05:17 UTC 2022
PRIMARY Merck Index
INN
5780
Created by admin on Fri Dec 16 18:05:17 UTC 2022 , Edited by admin on Fri Dec 16 18:05:17 UTC 2022
PRIMARY
CHEBI
8713
Created by admin on Fri Dec 16 18:05:17 UTC 2022 , Edited by admin on Fri Dec 16 18:05:17 UTC 2022
PRIMARY
NCI_THESAURUS
C62074
Created by admin on Fri Dec 16 18:05:17 UTC 2022 , Edited by admin on Fri Dec 16 18:05:17 UTC 2022
PRIMARY
FDA UNII
RJ84Y44811
Created by admin on Fri Dec 16 18:05:17 UTC 2022 , Edited by admin on Fri Dec 16 18:05:17 UTC 2022
PRIMARY
DAILYMED
RJ84Y44811
Created by admin on Fri Dec 16 18:05:17 UTC 2022 , Edited by admin on Fri Dec 16 18:05:17 UTC 2022
PRIMARY
CAS
85441-61-8
Created by admin on Fri Dec 16 18:05:17 UTC 2022 , Edited by admin on Fri Dec 16 18:05:17 UTC 2022
PRIMARY
EPA CompTox
DTXSID4023547
Created by admin on Fri Dec 16 18:05:17 UTC 2022 , Edited by admin on Fri Dec 16 18:05:17 UTC 2022
PRIMARY
MESH
C041125
Created by admin on Fri Dec 16 18:05:17 UTC 2022 , Edited by admin on Fri Dec 16 18:05:17 UTC 2022
PRIMARY
Related Record Type Details
TARGET -> INHIBITOR
BINDER->LIGAND
BINDING
METABOLIC ENZYME -> SUBSTRATE
SALT/SOLVATE -> PARENT
TRANSPORTER -> INHIBITOR
Related Record Type Details
METABOLITE ACTIVE -> PARENT
METABOLITE -> PARENT
Related Record Type Details
IMPURITY -> PARENT
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ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Volume of Distribution PHARMACOKINETIC
Biological Half-life PHARMACOKINETIC Elimination
PHARMACOKINETIC