MK6-83

Details

Stereochemistry	ACHIRAL
Molecular Formula	C16H20N2O2S2
Molecular Weight	336.472
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

CC1=CC=C(S1)S(=O)(=O)NC2=C(C=CC=C2)N3CCCCC3

InChI

InChIKey=IRGYSXZCDAWOOC-UHFFFAOYSA-N

InChI=1S/C16H20N2O2S2/c1-13-9-10-16(21-13)22(19,20)17-14-7-3-4-8-15(14)18-11-5-2-6-12-18/h3-4,7-10,17H,2,5-6,11-12H2,1H3

HIDE SMILES / InChI

Molecular Formula	C16H20N2O2S2
Molecular Weight	336.472
Charge	0
Count	MOL RATIO 1 MOL RATIO (average)

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description

MK6-83 is an activator of TRPML and its F408Δ and F465L mutants. MK6-83 restores endolysosomal trafficking and zinc homeostasis in lysosomes of mucolipidosis type IV (MLIV) mutant fibroblasts.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Mucolipin-1 1	Activator 1,447

Conditions

Condition	Modality	Targets	Highest Phase	Product
Mucolipidosis type IV 1	Primary		Basic research	Unknown

PubMed

PubMed

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Title	Date	PubMed
A small molecule restores function to TRPML1 mutant isoforms responsible for mucolipidosis type IV.	2014 Aug 14	25119295

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Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Activation of TRPML and its mutant forms was measured in HEK293 cells transientrly transfected with TRPML and using current–voltage relations of whole-lysosome planar patch-clamp experiments. MK6-83 activated ion channels with EC50 < 10 uM.

Substance Class	Chemical
Record UNII	RE9JUR6NT4
Record Status	`Validated (UNII)`
Record Version

Show entries

Name

Type

Language

2-THIOPHENESULFONAMIDE, 5-METHYL-N-(2-(1-PIPERIDINYL)PHENYL)-

Preferred Name

English

MK6-83

Code

English

5-METHYL-N-(2-(1-PIPERIDINYL)PHENYL)-2-THIOPHENESULFONAMIDE

Systematic Name

English

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Code System

Code

Type

Description

FDA UNII

RE9JUR6NT4

PRIMARY

EPA CompTox

DTXSID501336629

PRIMARY

CAS

1062271-24-2

PRIMARY

PUBCHEM

18191179

PRIMARY

WIKIPEDIA

MK6-83

PRIMARY

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Related Record

Type

Details


					RE9JUR6NT4

MK6-83

ACTIVE MOIETY

Amount:

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SMILES

InChI

Description<div class="info-popup-container"><div><span class="pop-sub-key ">Sources:&nbsp;</span><span class="pop-sub-val"><span class="ext-link"><a target="_self" href="https://www.ncbi.nlm.nih.gov/pubmed/25119295">https://www.ncbi.nlm.nih.gov/pubmed/25119295</a></span></span></div></div>

Originator

Approval Year

Targets

Conditions

PubMed

Sample Use Guides

Description