ROFLEPONIDE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C25H34F2O6
Molecular Weight	468.5307
Optical Activity	UNSPECIFIED
Defined Stereocenters	10 / 10
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]12C[C@@]3([H])[C@]4([H])C[C@H](F)C5=CC(=O)CC[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]3(C)[C@@]1(O[C@H](CCC)O2)C(=O)CO

InChI

InChIKey=IXTCZMJQGGONPY-XJAYAHQCSA-N

InChI=1S/C25H34F2O6/c1-4-5-21-32-20-10-14-15-9-17(26)16-8-13(29)6-7-22(16,2)24(15,27)18(30)11-23(14,3)25(20,33-21)19(31)12-28/h8,14-15,17-18,20-21,28,30H,4-7,9-12H2,1-3H3/t14-,15-,17-,18-,20+,21+,22-,23-,24-,25+/m0/s1

HIDE SMILES / InChI

Molecular Formula	C25H34F2O6
Molecular Weight	468.5307
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	10 / 10
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/10624832 | https://adisinsight.springer.com/drugs/800007303 | https://patents.google.com/patent/US20050032760A1/en

Rofleponide is a third generation synthetic glucocorticosteroid. This compound has high affinity for the rat thymus glucocorticoid receptor and showed a very high biotransformation rate in the human liver. Rofleponide was being investigated for its anti-inflammatory, immunosuppressive and anti-anaphylactic activity. It was evaluated in phase II clinical trials for its safety and efficacy in allergic rhinitis and asthma, and in a preclinical study for use in inflammatory bowel disease, but development of this drug was discontinued. Rofleponide was never marketed.

Originator

Approval Year

Patents

Substance Class	Chemical Created by `admin` on `Sat Dec 16 15:48:30 GMT 2023` Edited by `admin` on `Sat Dec 16 15:48:30 GMT 2023`
Record UNII	R9IQ7GVL3E
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

ROFLEPONIDE

Official Name

English

rofleponide [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C521