Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C20H27N5O6 |
| Molecular Weight | 433.4583 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCCCOC(=O)N[C@@H](CNC(=O)C[C@H]1CC(=NO1)C2=CC=C(C=C2)C(N)=N)C(O)=O
InChI
InChIKey=SRRJCHGGTPFZSS-ZBFHGGJFSA-N
InChI=1S/C20H27N5O6/c1-2-3-8-30-20(29)24-16(19(27)28)11-23-17(26)10-14-9-15(25-31-14)12-4-6-13(7-5-12)18(21)22/h4-7,14,16H,2-3,8-11H2,1H3,(H3,21,22)(H,23,26)(H,24,29)(H,27,28)/t14-,16+/m1/s1
| Molecular Formula | C20H27N5O6 |
| Molecular Weight | 433.4583 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Roxifiban (also known as DMP754), a potent antiplatelet agent in inhibiting platelet aggregation, and has a high specificity and affinity for human platelet glycoprotein IIb/IIIa complex (GPIIb/IIIa) receptors. Roxifiban participated in clinical trials phase III for the treatment of peripheral arterial disorders. This drug was also well tolerated in patients with chronic stable angina pectoris and was studied in the treatment of heparin-induced thrombocytopenia, and thrombosis. However, the development of this drug appears to have been discontinued.
Approval Year
Sample Use Guides
Ninety-eight patients were randomized to receive either a placebo or 1 of 8 oral dosages of roxifiban. Twenty-two patients were enrolled in multiple-dose regimens, bringing the total study population to 120. The oral dosages were 0.25, 0.5, 0.75, 1, 1.25, 1.5, 2, or 2.5 mg/day for up to 30 days.
Route of Administration:
Oral
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 19:51:25 GMT 2023
by
admin
on
Sat Dec 16 19:51:25 GMT 2023
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| Record UNII |
R96EWZ6KUZ
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| Record Status |
Validated (UNII)
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| Record Version |
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170902-52-0
Created by
admin on Sat Dec 16 19:51:25 GMT 2023 , Edited by admin on Sat Dec 16 19:51:25 GMT 2023
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177231
Created by
admin on Sat Dec 16 19:51:25 GMT 2023 , Edited by admin on Sat Dec 16 19:51:25 GMT 2023
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R96EWZ6KUZ
Created by
admin on Sat Dec 16 19:51:25 GMT 2023 , Edited by admin on Sat Dec 16 19:51:25 GMT 2023
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PRIMARY |
| Related Record | Type | Details | ||
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TARGET -> INHIBITOR |
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| Related Record | Type | Details | ||
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PRODRUG -> METABOLITE ACTIVE |
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ACTIVE MOIETY |
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