RICASETRON

Details

Stereochemistry	ACHIRAL
Molecular Formula	C19H27N3O
Molecular Weight	313.4372
Optical Activity	UNSPECIFIED
Defined Stereocenters	3 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN1[C@H]2CC[C@@H]1C[C@@H](C2)NC(=O)N3CC(C)(C)C4=C3C=CC=C4

InChI

InChIKey=ILXWRFDRNAKTDD-QDMKHBRRSA-N

InChI=1S/C19H27N3O/c1-19(2)12-22(17-7-5-4-6-16(17)19)18(23)20-13-10-14-8-9-15(11-13)21(14)3/h4-7,13-15H,8-12H2,1-3H3,(H,20,23)/t13-,14+,15-

HIDE SMILES / InChI

Molecular Formula	C19H27N3O
Molecular Weight	313.4372
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	3 / 3
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.sciencedirect.com/science/article/pii/002839089390180B | https://www.ncbi.nlm.nih.gov/pubmed/7831418 | https://adisinsight.springer.com/drugs/800001328 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4399007/

Ricasetron (BRL 46470) is a selective serotonin 5-HT3 receptor antagonist. This compound was found to be a potent anxiolytic agent and have antiemetic (effective against vomiting and nausea) effects when tested in animal models. Moreover, this drug was reported to have less side effects than benzodiazepines (used for anxiety). Ricasetron was not further developed for medical use.

Originator

Approval Year

PubMed

Title	Date	PubMed
Pharmacological comparison of human homomeric 5-HT3A receptors versus heteromeric 5-HT3A/3B receptors.	2001 Aug	11489465

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:21:20 UTC 2023` Edited by `admin` on `Fri Dec 15 16:21:20 UTC 2023`
Record UNII	R92JB88O88
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

RICASETRON

Official Name

English

ricasetron [INN]

Common Name

English

BRL46470

Code

English

BRL-46470

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C94726