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Details

Stereochemistry RACEMIC
Molecular Formula C21H30N4O4
Molecular Weight 402.4881
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CINITAPRIDE

SMILES

CCOc1cc(c(cc1C(=NC2CCN(CC2)CC3CC=CCC3)O)N(=O)=O)N

InChI

InChIKey=ZDLBNXXKDMLZMF-UHFFFAOYSA-N
InChI=1S/C21H30N4O4/c1-2-29-20-13-18(22)19(25(27)28)12-17(20)21(26)23-16-8-10-24(11-9-16)14-15-6-4-3-5-7-15/h3-4,12-13,15-16H,2,5-11,14,22H2,1H3,(H,23,26)

HIDE SMILES / InChI

Molecular Formula C21H30N4O4
Molecular Weight 402.4881
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Cinitapride is an agonist of 5-HT4 and 5-HT1 receptors and antagonist of 5-HT2 receptors. Cinitapride is marketed worldwide for the treatment of gastrointestinal disorders related to motility such as indigestion or functional or non-ulcer dyspepsia, gastroesophageal reflux diseases, delay in gastric emptying and vomiting.

Approval Year

PubMed

PubMed

TitleDatePubMed
[Efficacy and tolerance of cinitapride on the disturbances of gastrointestinal transit].
1991 Jul-Sep
[Cinitapride in the treatment of gastroesophageal reflux. Comparative study with metoclopramide and placebo].
1992 Jan-Mar
[Metoclopramide versus cinitapride in the treatment of functional dyspepsia].
1993 Jul
Cinitapride protects against ethanol-induced gastric mucosal injury in rats: role of 5-hydroxytryptamine, prostaglandins and sulfhydryl compounds.
1997 Apr
Effects of cinitapride on gastric ulceration and secretion in rats.
1998 Mar
[Prokinetic agents as a cause of granulomatous interstitial nephritis].
2007 Dec
The prokinetic cinitapride has no clinically relevant pharmacokinetic interaction and effect on QT during coadministration with ketoconazole.
2007 Jul
[Efficacy and tolerability of cinitapride in the treatment of functional dyspepsia and delayed gastric emptying].
2009 Dec
Substance Class Chemical
Created
by admin
on Fri Jun 25 22:57:41 UTC 2021
Edited
by admin
on Fri Jun 25 22:57:41 UTC 2021
Record UNII
R8I97I2L24
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CINITAPRIDE
INN   MART.   MI   WHO-DD  
INN  
Official Name English
CINITAPRIDE [MI]
Common Name English
CINITAPRIDE [WHO-DD]
Common Name English
CINITAPRIDE [MART.]
Common Name English
CINITAPRIDE [INN]
Common Name English
PAXAPRIDE
Brand Name English
Classification Tree Code System Code
WHO-ATC A03FA08
Created by admin on Fri Jun 25 22:57:41 UTC 2021 , Edited by admin on Fri Jun 25 22:57:41 UTC 2021
NCI_THESAURUS C66885
Created by admin on Fri Jun 25 22:57:41 UTC 2021 , Edited by admin on Fri Jun 25 22:57:41 UTC 2021
NCI_THESAURUS C47794
Created by admin on Fri Jun 25 22:57:41 UTC 2021 , Edited by admin on Fri Jun 25 22:57:41 UTC 2021
Code System Code Type Description
CAS
66564-14-5
Created by admin on Fri Jun 25 22:57:41 UTC 2021 , Edited by admin on Fri Jun 25 22:57:41 UTC 2021
PRIMARY
EVMPD
SUB06298MIG
Created by admin on Fri Jun 25 22:57:41 UTC 2021 , Edited by admin on Fri Jun 25 22:57:41 UTC 2021
PRIMARY
ChEMBL
CHEMBL2104523
Created by admin on Fri Jun 25 22:57:41 UTC 2021 , Edited by admin on Fri Jun 25 22:57:41 UTC 2021
PRIMARY
PUBCHEM
68867
Created by admin on Fri Jun 25 22:57:41 UTC 2021 , Edited by admin on Fri Jun 25 22:57:41 UTC 2021
PRIMARY
DRUG CENTRAL
652
Created by admin on Fri Jun 25 22:57:41 UTC 2021 , Edited by admin on Fri Jun 25 22:57:41 UTC 2021
PRIMARY
FDA UNII
R8I97I2L24
Created by admin on Fri Jun 25 22:57:41 UTC 2021 , Edited by admin on Fri Jun 25 22:57:41 UTC 2021
PRIMARY
INN
4555
Created by admin on Fri Jun 25 22:57:41 UTC 2021 , Edited by admin on Fri Jun 25 22:57:41 UTC 2021
PRIMARY
NCI_THESAURUS
C77257
Created by admin on Fri Jun 25 22:57:41 UTC 2021 , Edited by admin on Fri Jun 25 22:57:41 UTC 2021
PRIMARY
MERCK INDEX
M3565
Created by admin on Fri Jun 25 22:57:41 UTC 2021 , Edited by admin on Fri Jun 25 22:57:41 UTC 2021
PRIMARY Merck Index
WIKIPEDIA
CINITAPRIDE
Created by admin on Fri Jun 25 22:57:41 UTC 2021 , Edited by admin on Fri Jun 25 22:57:41 UTC 2021
PRIMARY
MESH
C045316
Created by admin on Fri Jun 25 22:57:41 UTC 2021 , Edited by admin on Fri Jun 25 22:57:41 UTC 2021
PRIMARY
RXCUI
21125
Created by admin on Fri Jun 25 22:57:41 UTC 2021 , Edited by admin on Fri Jun 25 22:57:41 UTC 2021
PRIMARY RxNorm
DRUG BANK
DB08810
Created by admin on Fri Jun 25 22:57:41 UTC 2021 , Edited by admin on Fri Jun 25 22:57:41 UTC 2021
PRIMARY
Related Record Type Details
ENANTIOMER -> RACEMATE
ENANTIOMER -> RACEMATE
TARGET -> INHIBITOR
Related Record Type Details
ACTIVE MOIETY