SULFAETHIDOLE

US Previously Marketed

First approved in 1956

Details

Stereochemistry	ACHIRAL
Molecular Formula	C10H12N4O2S2
Molecular Weight	284.358
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCC1=NN=C(NS(=O)(=O)C2=CC=C(N)C=C2)S1

InChI

InChIKey=SVYBEBLNQGDRHF-UHFFFAOYSA-N

InChI=1S/C10H12N4O2S2/c1-2-9-12-13-10(17-9)14-18(15,16)8-5-3-7(11)4-6-8/h3-6H,2,11H2,1H3,(H,13,14)

HIDE SMILES / InChI

Molecular Formula	C10H12N4O2S2
Molecular Weight	284.358
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.drugfuture.com/chemdata/sulfaethidole.html | https://www.ndrugs.com/?s=sulfamethizole/sulfaethidole | https://www.ncbi.nlm.nih.gov/pubmed/13636044

Sulfaethidole is an antibacterial agent, indicated for the treatment of urinary tract infection.

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Urinary tract infections 205 Sources: https://www.ncbi.nlm.nih.gov/pubmed/13636044 http://pharmabook.net/en/protivomikrobnye--protivoparaz/sinteti4eskie-antibakterialnye/sulfanilamidy/sulfaethidole.html	Curative		Approved 8429	Sul-Spansion Approved Use Urinary tract infections Launch Date 1958

C_max

Value	Dose	Co-administered	Analyte	Population
125 μg/mL EXPERIMENT https://doi.org/10.1002/j.1552-4604.1980.tb02547.x	1 g single, oral dose: 1 g route of administration: Oral experiment type: SINGLE co-administered: DICLOXACILLIN	DICLOXACILLIN	SULFAETHIDOLE serum	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN

F_unbound

Value	Dose	Co-administered	Analyte	Population
2.5% OTHER https://www.karger.com/Article/Abstract/414185			SULFAETHIDOLE plasma	Homo sapiens population: UNKNOWN age: UNKNOWN sex: UNKNOWN food status: UNKNOWN

Sourcing

Vendor/Aggregator	ID	URL
3B Scientific (Wuhan) Corp	3B3-044092	http://www.3bsc.com/index/pro_info.php?id=76291
AA Blocks	AA005SWT	https://www.aablocks.com/goods/Goods/detail?id=AA005SWT
AHH Chemical co.,ltd	MT-41364	http://www.ahhchemical.com/product/MT-41364.html
Acadechem	ACDR-030610	http://acadechemical.com/product/43112
Angene	AGN-PC-0JK7YM	http://www.angenechemical.com/productshow/AGN-PC-0JK7YM.html
Aronis	ARONIS018063	http://www.aronis.ru/store/index.php?main_page=product_info&cPath=1&products_id=1486
Aurum Pharmatech LLC	Z-2045	http://www.Aurumpharmatech.com/Product/ProductDetails/Z_2045
BLD Pharm	BD94193	http://www.bldpharm.com/products/94-19-9.html
ChemMol	80101503	http://www.chemmol.com/chemmol/80101503.html
Chemspace	CSSB00000389409	https://chem-space.com/CSSB00000389409
Clearsynth	CS-M-04062	https://www.clearsynth.com/en/CSM04062.html
Finetech	FT-0676645	http://www.finetechnology-ind.com/prod/detail/pub/94-19-9.html
LGC Standards	DRE-C16990660	https://www.lgcstandards.com/US/en/p/DRE-C16990660
Matrix Scientific	8104	https://www.matrixscientific.com/008104.html
Oakwood	30934	http://www.oakwoodchemical.com/ProductsList.aspx?CategoryID=-2&txtSearch=24812&ExtHyperLink=1
Smolecule	S592133	https://www.smolecule.com/products/s592133
THE BioTek	bt-318415	https://www.thebiotek.com/product/others/bt-318415
eNovation Chemicals	D112666	https://www.enovationchem.com/ProductDetails.asp?ProductID=D112666
mcule	MCULE-9256808333	https://mcule.com/MCULE-9256808333/

PubMed

Title	Date	PubMed
Drug absorption VII: influence of mesenteric blood flow on intestinal drug absorption in dogs.	1975 Apr	1173597
Influence of sulfaethidole on the human pharmacokinetics of dicloxacillin.	1980 Aug-Sep	6893599
Pharmacokinetics of sulfaethidole in the rat: nonlinear multicompartment solution.	1982 Feb	6896071

Patents

Sample Use Guides

In Vivo Use Guide

Urinary tract infections Adult: 1.5-4 g/day in 3-4 divided doses. Child: 30-45 mg/kg/day in 4 divided doses.

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:18:19 GMT 2023` Edited by `admin` on `Fri Dec 15 15:18:19 GMT 2023`
Record UNII	R77Q4O5ZMD
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SULFAETHIDOLE

Official Name

English

Sulfaethidole [WHO-DD]

Common Name

English

sulfaethidole [INN]

Common Name

English

SUL-SPANSION

Brand Name

English

SULPHAETHIDOLE

Common Name

English

SULFAETHIDOLE [MI]

Common Name

English

BENZENESULFONAMIDE, 4-AMINO-N-(5-ETHYL-1,3,4-THIADIAZOL-2-YL)-

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29739