CENTPROPAZINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C22H28N2O3
Molecular Weight	368.4693
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

CCC(=O)C1=CC=C(OCC(O)CN2CCN(CC2)C3=CC=CC=C3)C=C1

InChI

InChIKey=ZQPXSRTZFYHSFB-UHFFFAOYSA-N

InChI=1S/C22H28N2O3/c1-2-22(26)18-8-10-21(11-9-18)27-17-20(25)16-23-12-14-24(15-13-23)19-6-4-3-5-7-19/h3-11,20,25H,2,12-17H2,1H3

HIDE SMILES / InChI

Molecular Formula	C22H28N2O3
Molecular Weight	368.4693
Charge	0
Count	MOL RATIO 1 MOL RATIO (average)

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Approval Year

Targets

Targets

Primary Target	Pharmacology	Condition	Potency
serotonin receptor signaling pathway 6	Modulator 846

Substance Class	Chemical
Record UNII	R5YPG9LA47
Record Status	`Validated (UNII)`
Record Version

Show entries

Name

Type

Language

CENTPROPAZINE

Common Name

English

1-(4-(2-HYDROXY-3-(4-PHENYLPIPERAZIN-1-YL)PROPOXY)PHENYL)PROPAN-1-ONE

Preferred Name

English

4'-(2-HYDROXY-3-(4-PHENYLPIPERAZIN-1-YL)PROPOXY)PROPIOPHENONE

Systematic Name

English

1-PROPANONE, 1-(4-(2-HYDROXY-3-(4-PHENYL-1-PIPERAZINYL)PROPOXY)PHENYL)-

Systematic Name

English

Showing 1 to 4 of 4 entries

Previous1Next

Show entries

Code System

Code

Type

Description

MANUFACTURER PRODUCT INFORMATION

CENTPROPAZINE

PRIMARY

CAS No. 34675-77-9; Chemical Name: Centpropazine

CAS

91315-34-3

PRIMARY

EPA CompTox

DTXSID00919825

PRIMARY

PUBCHEM

118176

PRIMARY

FDA UNII

R5YPG9LA47

PRIMARY

Showing 1 to 5 of 5 entries

Previous1Next

Show entries

Related Record

Type

Details


					R5YPG9LA47

CENTPROPAZINE

ACTIVE MOIETY

Comments:

Single oral doses of 10 to 160 mg centpropazine, a new antidepressant (synthesized by CDRI, Lucknow, India) were administered to groups of 4-5 male volunteers, each dose being interspersed with placebo in a double blind, non-crossover study by random distribution. The drug was well tolerated. Drowsiness, heaviness, weakness and/or headache were reported only at doses of 120 mg and above. No adverse effect was noted in various laboratory tests, ECG or vital parameters.

Amount:


					R5YPG9LA47

CENTPROPAZINE

ACTIVE MOIETY

Comments:

Centpropazine is a new antidepressant with minimal anticholinergic effects in preclinical animal models. In this study centpropazine has been compared with imipramine in a double blind randomized multicentric study. A total of 159 patients of major depressive disorder (79 in centpropazine group and 80 in imipramine group) from four centres were included in this trial. Each patient was randomised to receive either centpropazine in a dose of 40 to 120 mg per day or imipramine in a dose of 50 to 150 mg per day for a period of six weeks. The antidepressant efficacy of centpropazine was comparable to imipramine but anticholinergic side effects were four times less than imipramine.

Amount:

Showing 1 to 2 of 2 entries

Previous1Next