PIROCTONE

Details

Stereochemistry	RACEMIC
Molecular Formula	C14H23NO2
Molecular Weight	237.3379
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(CC1=CC(C)=CC(=O)N1O)CC(C)(C)C

InChI

InChIKey=OIQJEQLSYJSNDS-UHFFFAOYSA-N

InChI=1S/C14H23NO2/c1-10-6-12(15(17)13(16)8-10)7-11(2)9-14(3,4)5/h6,8,11,17H,7,9H2,1-5H3

HIDE SMILES / InChI

Molecular Formula	C14H23NO2
Molecular Weight	237.3379
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/21282741 | https://www.ncbi.nlm.nih.gov/pubmed/21272039

Piroctone olamine is used in combination with other substances as a part of shampoo effectively reduced the amount of dandruff and, at the same time, provided hair conditioning advantages. Recently was shown, that piroctone olamine could induce apoptosis and possessed a significant in vivo effect against myeloma.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Dandruff 7 Sources: https://www.ncbi.nlm.nih.gov/pubmed/21272039	Primary		Not Provided 511	Unknown Approved Use Unknown
Myeloma 4 Sources: https://www.ncbi.nlm.nih.gov/pubmed/21282741	Primary		Preclinical	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Allergic contact dermatitis to propyl gallate and pentylene glycol in an emollient cream.	2010-05	20546226
The in vitro effect of a collagenolytic enzyme inhibitor on lesion development in root dentin.	2009-04	19626976
Treatment of mild to moderate seborrhoeic dermatitis with MAS064D (Sebclair), a novel topical medical device: results of a pilot, randomized, double-blind, controlled trial.	2008-03	18269596
In vitro investigations on the mode of action of the hydroxypyridone antimycotics rilopirox and piroctone on Candida albicans.	2006-05	16681805
[Determination of antidangdruff agent salicylic acid, zinc pyrithione, octopirox, climbazole and ketoconazole in shampoo by high performance liquid chromatography].	2005-09	16329615
In vitro antimycotic activity and nail permeation models of a piroctone olamine (octopirox) containing transungual water soluble technology.	2005	16149717
Enhanced delivery of an anti-dandruff active in a shampoo vehicle.	2004	15645098
Effect of residence time on the efficacy of antidandruff shampoos.	2003-12	18494909
Nudging hair shedding by antidandruff shampoos. A comparison of 1% ketoconazole, 1% piroctone olamine and 1% zinc pyrithione formulations.	2002-10	18498517

Patents

Sample Use Guides

In Vivo Use Guide

shampoo

Route of Administration: Topical

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:26:45 GMT 2025` Edited by `admin` on `Mon Mar 31 18:26:45 GMT 2025`
Record UNII	R49EFA73Q7
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PIROCTONE [MI]

Preferred Name

English

PIROCTONE

Official Name

English

PIROCTONOL

Common Name

English

PIROCTONE [USAN]

Common Name

English

Piroctone [WHO-DD]

Common Name

English

piroctone [INN]

Common Name

English

1-HYDROXY-4-METHYL-6(2,4,4-TRIMETHYLPENTYL)-2-PYRIDONE

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C78284