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Details

Stereochemistry RACEMIC
Molecular Formula C13H14N2O
Molecular Weight 214.2631
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PHENYRAMIDOL

SMILES

OC(CNC1=CC=CC=N1)C2=CC=CC=C2

InChI

InChIKey=ZEAJXCPGHPJVNP-UHFFFAOYSA-N
InChI=1S/C13H14N2O/c16-12(11-6-2-1-3-7-11)10-15-13-8-4-5-9-14-13/h1-9,12,16H,10H2,(H,14,15)

HIDE SMILES / InChI
Molecular Formula C13H14N2O
Molecular Weight 214.2631
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Description

PHENYRAMIDOL (ANALEXIN®), also known as fenyramidol, is an aminopyridine derivative, used as analgesic and muscle relaxant. It is considered as a drug that possibly causes hepatotoxicity.

Approval Year

1960
107
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Approved
8429
Analexin

Approved Use

Analgesic, Muscle relaxant

Launch Date

1959
Doses

Doses

DosePopulationAdverse events​
400 mg 2 times / day multiple, oral
Dose: 400 mg, 2 times / day
Route: oral
Route: multiple
Dose: 400 mg, 2 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/12921508
unhealthy, 70 years
n = 1
Health Status: unhealthy
Age Group: 70 years
Sex: M
Population Size: 1
Sources:
https://pubmed.ncbi.nlm.nih.gov/12921508
Disc. AE: Liver injury...
AEs leading to
discontinuation/dose reduction:
Liver injury
Sources:
https://pubmed.ncbi.nlm.nih.gov/12921508
AEs

AEs

AESignificanceDosePopulation
Liver injury Disc. AE
400 mg 2 times / day multiple, oral
Dose: 400 mg, 2 times / day
Route: oral
Route: multiple
Dose: 400 mg, 2 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/12921508
unhealthy, 70 years
n = 1
Health Status: unhealthy
Age Group: 70 years
Sex: M
Population Size: 1
Sources:
https://pubmed.ncbi.nlm.nih.gov/12921508
Sourcing

Sourcing

Vendor/AggregatorIDURL
001 Chemical
DY548700
https://www.001chemical.com/chem/326-43-2
ABI Chem
AC1L1T44
Alfa Chemistry
ACM326432
BOC Sciences
326-43-2
BOC Sciences
553-69-5
Chemieliva Pharmaceutical Co., Ltd
PBCM0639514
Chemspace
CSC000251451
Chemspace
CSC010499475
Chemspace
CSC010556475
Compound Cloud
9469
Compound Cloud
9470
Enamine
BBV-24869013
Enamine
BBV-45306755
Enamine
BBV-45369977
Enamine
Z31268347
Finetech
FT-0699783
http://www.finetechnology-ind.com/prod/detail/pub/553-69-5.html
HongKong Chemhere
SCA18366
MolPort
MolPort-006-111-788
Molcore
MC548700
https://www.molcore.com/product/326-43-2
NCI Plated 2007
17777
NovoSeek
9470
Smolecule
S576140
https://www.smolecule.com/products/s576140
THE BioTek
bt-368553
https://www.thebiotek.com/product/others/bt-368553
Yick-Vic Chemicals & Pharmaceuticals (HK) Ltd.
PH-2488AA
ZINC
ZINC000022910917
http://zinc15.docking.org/substances/ZINC000022910917
ZINC
ZINC000022910921
http://zinc15.docking.org/substances/ZINC000022910921
eMolecules
37191127
eMolecules
76759028
eNovation Chemicals
D140204
mcule
MCULE-9231150796
https://mcule.com/MCULE-9231150796/
PubMed

PubMed

TitleDatePubMed
Analgesic effectiveness of phenyramidol hydrochloride, a new aminopyridine derivative.
1959 Sep
Pharmacology of phenyramidol (IN511) with emphasis on analgesic and muscle-relaxant effects.
1960 Mar 30
Phenyramidol-associated liver toxicity.
2003 Sep
Patents

Patents

20020006951
5
Substance Class Chemical
Created
by admin
on Fri Dec 15 19:08:25 GMT 2023
Edited
by admin
on Fri Dec 15 19:08:25 GMT 2023
Record UNII
R3V02WL7O3
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
PHENYRAMIDOL
MI  
Common Name English
BENZYL ALCOHOL, .ALPHA.-((2-PYRIDYLAMINO)METHYL)-
Systematic Name English
CABRAL
Common Name English
MJ-505
Code English
EVASPRIN
Common Name English
NSC-23634
Code English
FENYRAMIDOL
INN   WHO-DD  
INN  
Official Name English
fenyramidol [INN]
Common Name English
(±)-PHENYRAMIDOL
Common Name English
PHENYRAMIDOL [MI]
Common Name English
Fenyramidol [WHO-DD]
Common Name English
BENZENEMETHANOL, .ALPHA.-((2-PYRIDINYLAMINO)METHYL)-
Systematic Name English
Classification Tree Code System Code
NCI_THESAURUS C29696
Created by admin on Fri Dec 15 19:08:25 GMT 2023 , Edited by admin on Fri Dec 15 19:08:25 GMT 2023
WHO-ATC M03BX30
Created by admin on Fri Dec 15 19:08:25 GMT 2023 , Edited by admin on Fri Dec 15 19:08:25 GMT 2023
WHO-VATC QM03BX30
Created by admin on Fri Dec 15 19:08:25 GMT 2023 , Edited by admin on Fri Dec 15 19:08:25 GMT 2023
Code System Code Type Description
MESH
C478450
Created by admin on Fri Dec 15 19:08:25 GMT 2023 , Edited by admin on Fri Dec 15 19:08:25 GMT 2023
PRIMARY
ECHA (EC/EINECS)
209-044-7
Created by admin on Fri Dec 15 19:08:25 GMT 2023 , Edited by admin on Fri Dec 15 19:08:25 GMT 2023
PRIMARY
INN
1204
Created by admin on Fri Dec 15 19:08:25 GMT 2023 , Edited by admin on Fri Dec 15 19:08:25 GMT 2023
PRIMARY
MERCK INDEX
m8702
Created by admin on Fri Dec 15 19:08:25 GMT 2023 , Edited by admin on Fri Dec 15 19:08:25 GMT 2023
PRIMARY Merck Index
CAS
553-69-5
Created by admin on Fri Dec 15 19:08:25 GMT 2023 , Edited by admin on Fri Dec 15 19:08:25 GMT 2023
PRIMARY
PUBCHEM
9470
Created by admin on Fri Dec 15 19:08:25 GMT 2023 , Edited by admin on Fri Dec 15 19:08:25 GMT 2023
PRIMARY
SMS_ID
100000081490
Created by admin on Fri Dec 15 19:08:25 GMT 2023 , Edited by admin on Fri Dec 15 19:08:25 GMT 2023
PRIMARY
WIKIPEDIA
FENYRAMIDOL
Created by admin on Fri Dec 15 19:08:25 GMT 2023 , Edited by admin on Fri Dec 15 19:08:25 GMT 2023
PRIMARY
EPA CompTox
DTXSID00862185
Created by admin on Fri Dec 15 19:08:25 GMT 2023 , Edited by admin on Fri Dec 15 19:08:25 GMT 2023
PRIMARY
DRUG CENTRAL
2151
Created by admin on Fri Dec 15 19:08:25 GMT 2023 , Edited by admin on Fri Dec 15 19:08:25 GMT 2023
PRIMARY
ChEMBL
CHEMBL1697767
Created by admin on Fri Dec 15 19:08:25 GMT 2023 , Edited by admin on Fri Dec 15 19:08:25 GMT 2023
PRIMARY
EVMPD
SUB07602MIG
Created by admin on Fri Dec 15 19:08:25 GMT 2023 , Edited by admin on Fri Dec 15 19:08:25 GMT 2023
PRIMARY
NCI_THESAURUS
C84054
Created by admin on Fri Dec 15 19:08:25 GMT 2023 , Edited by admin on Fri Dec 15 19:08:25 GMT 2023
PRIMARY
DRUG BANK
DB13414
Created by admin on Fri Dec 15 19:08:25 GMT 2023 , Edited by admin on Fri Dec 15 19:08:25 GMT 2023
PRIMARY
NSC
23634
Created by admin on Fri Dec 15 19:08:25 GMT 2023 , Edited by admin on Fri Dec 15 19:08:25 GMT 2023
PRIMARY
FDA UNII
R3V02WL7O3
Created by admin on Fri Dec 15 19:08:25 GMT 2023 , Edited by admin on Fri Dec 15 19:08:25 GMT 2023
PRIMARY
Related Record Type Details
Structure of PHENYRAMIDOL SALICYLATE
SALT/SOLVATE -> PARENT
Structure of FENYRAMIDOL, (R)-
ENANTIOMER -> RACEMATE
Structure of FENYRAMIDOL, (S)-
ENANTIOMER -> RACEMATE
Structure of PHENYRAMIDOL HYDROCHLORIDE
SALT/SOLVATE -> PARENT
Related Record Type Details
Structure of PHENYRAMIDOL
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