EPOLAMINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C6H13NO
Molecular Weight	115.1735
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OCCN1CCCC1

InChI

InChIKey=XBRDBODLCHKXHI-UHFFFAOYSA-N

InChI=1S/C6H13NO/c8-6-5-7-3-1-2-4-7/h8H,1-6H2

HIDE SMILES / InChI

Molecular Formula	C6H13NO
Molecular Weight	115.1735
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/8980926 | https://www.flectorpatch.com/about-flector-patch

Epolamine (N-(2-hydroxyethyl)pyrrolidine) is a strong base used to salify organic acids of pharmaceutical interest in order to improve their solubility in water. Diclofenac epolamine (Flector) is an example of the epolamine salt of a drug.

Approval Year

PubMed

Title	Date	PubMed
Topical nonsteroidal anti-inflammatory drugs for the treatment of pain due to soft tissue injury: diclofenac epolamine topical patch.	2010-11-10	21197326
In vitro cytotoxicity of benzopyranone derivatives with basic side chain against human lung cell lines.	2010-11	21115914
Topical diclofenac epolamine patch 1.3% for treatment of acute pain caused by soft tissue injury.	2010-10	20666849
Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography.	2009-08-13	19618939
Topical diclofenac: clinical effectiveness and current uses in osteoarthritis of the knee and soft tissue injuries.	2008-11	18937623
Review of the pharmaceutical properties and clinical effects of the topical NSAID formulation, diclofenac epolamine.	2008-10	18814824
Ex vivo study of transdermal permeation of four diclofenac salts from different vehicles.	2007-04	17286288
Diclofenac pyrrolidine versus Ketoprofen for the relief of pain from episiotomy: a randomized controlled trial.	2005-10	16167910
Comparison of the physicochemical properties of the N-(2-hydroxyethyl) pyrrolidine, diethylamine and sodium salt forms of diclofenac.	2001-07-17	11427358

Patents

Substance Class	Chemical Created by `admin` on `Wed Apr 02 06:56:19 GMT 2025` Edited by `admin` on `Wed Apr 02 06:56:19 GMT 2025`
Record UNII	R3D835XVCR
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

EPOLAMINE

Official Name

English

N-(2-HYDROXYETHYL)PYRROLIDINE

Preferred Name

English

epolamine [INN]

Common Name

English

NSC-26883

Code

English

Code System Code Type Description

EPA CompTox

DTXSID70183733