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Details

Stereochemistry ABSOLUTE
Molecular Formula C8H13N5O4
Molecular Weight 243.2203
Optical Activity UNSPECIFIED
Defined Stereocenters 4 / 4
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TARIBAVIRIN

SMILES

C([C@]1([H])[C@]([H])([C@]([H])([C@]([H])(n2cnc(C(=N)N)n2)O1)O)O)O

InChI

InChIKey=NHKZSTHOYNWEEZ-AFCXAGJDSA-N
InChI=1S/C8H13N5O4/c9-6(10)7-11-2-13(12-7)8-5(16)4(15)3(1-14)17-8/h2-5,8,14-16H,1H2,(H3,9,10)/t3-,4-,5-,8-/m1/s1

HIDE SMILES / InChI

Molecular Formula C8H13N5O4
Molecular Weight 243.2203
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 4 / 4
E/Z Centers 0
Optical Activity UNSPECIFIED

Taribavirin, an oral prodrug of ribavirin that was developed as nucleoside antimetabolite, which interferes with duplication of viral genetic material. Taribavirin was studied in phase III clinical trial for the treatment of chronic hepatitis C patients. However, this drug not yet approved for pharmaceutical use.

Approval Year

PubMed

PubMed

TitleDatePubMed
Synthesis and antiviral activity of 1,2,4-triazole-3-thiocarboxamide and 1,2,4-triazole-3-carboxamidine ribonucleosides.
1973 Aug
Effects of ribamidine, a 3-carboxamidine derivative of ribavirin, on experimentally induced Phlebovirus infections.
1988 Dec 1
Treatment of lethal Pichinde virus infections in weanling LVG/Lak hamsters with ribavirin, ribamidine, selenazofurin, and ampligen.
1993 Jan
Antiviral and immunomodulating inhibitors of experimentally-induced Punta Toro virus infections.
1994 Oct
Identification of active antiviral compounds against a New York isolate of West Nile virus.
2002 Jul
Viramidine (Ribapharm).
2002 Nov
A simple assay for determining antiviral activity against Crimean-Congo hemorrhagic fever virus.
2004 Apr
Dual-action mechanism of viramidine functioning as a prodrug and as a catabolic inhibitor for ribavirin.
2004 Oct
In vitro and in vivo influenza virus-inhibitory effects of viramidine.
2005 Oct
New strategies for the treatment of hepatitis C virus infection and implications of resistance to new direct-acting antiviral agents.
2010
Antiviral therapy for hepatitis C virus: beyond the standard of care.
2010 Apr
Virologic response rates of weight-based taribavirin versus ribavirin in treatment-naive patients with genotype 1 chronic hepatitis C.
2010 Oct

Sample Use Guides

viramidine (TARIBAVIRIN) 600 mg BID
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Sat Jun 26 07:25:55 UTC 2021
Edited
by admin
on Sat Jun 26 07:25:55 UTC 2021
Record UNII
R3B1994K2E
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
TARIBAVIRIN
INN   MI   WHO-DD  
INN  
Official Name English
TARIBAVIRIN [WHO-DD]
Common Name English
TARIBAVIRIN [MI]
Common Name English
TARIBAVIRIN [INN]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C281
Created by admin on Sat Jun 26 07:25:55 UTC 2021 , Edited by admin on Sat Jun 26 07:25:55 UTC 2021
Code System Code Type Description
CAS
119567-79-2
Created by admin on Sat Jun 26 07:25:55 UTC 2021 , Edited by admin on Sat Jun 26 07:25:55 UTC 2021
PRIMARY
NCI_THESAURUS
C76499
Created by admin on Sat Jun 26 07:25:55 UTC 2021 , Edited by admin on Sat Jun 26 07:25:55 UTC 2021
PRIMARY
DRUG BANK
DB06408
Created by admin on Sat Jun 26 07:25:55 UTC 2021 , Edited by admin on Sat Jun 26 07:25:55 UTC 2021
PRIMARY
DRUG CENTRAL
3582
Created by admin on Sat Jun 26 07:25:55 UTC 2021 , Edited by admin on Sat Jun 26 07:25:55 UTC 2021
PRIMARY
PUBCHEM
451448
Created by admin on Sat Jun 26 07:25:55 UTC 2021 , Edited by admin on Sat Jun 26 07:25:55 UTC 2021
PRIMARY
INN
8619
Created by admin on Sat Jun 26 07:25:55 UTC 2021 , Edited by admin on Sat Jun 26 07:25:55 UTC 2021
PRIMARY
ChEMBL
CHEMBL2111108
Created by admin on Sat Jun 26 07:25:55 UTC 2021 , Edited by admin on Sat Jun 26 07:25:55 UTC 2021
PRIMARY
FDA UNII
R3B1994K2E
Created by admin on Sat Jun 26 07:25:55 UTC 2021 , Edited by admin on Sat Jun 26 07:25:55 UTC 2021
PRIMARY
WIKIPEDIA
TARIBAVIRIN
Created by admin on Sat Jun 26 07:25:55 UTC 2021 , Edited by admin on Sat Jun 26 07:25:55 UTC 2021
PRIMARY
MERCK INDEX
M10467
Created by admin on Sat Jun 26 07:25:55 UTC 2021 , Edited by admin on Sat Jun 26 07:25:55 UTC 2021
PRIMARY Merck Index
Related Record Type Details
SALT/SOLVATE -> PARENT
Related Record Type Details
METABOLITE ACTIVE -> PRODRUG