Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C26H34O5S |
Molecular Weight | 458.61 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 2 / 2 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
O[C@H]([C@H](SCCC(O)=O)C1=C(CCCCCCCCC2=CC=CC=C2)C=CC=C1)C(O)=O
InChI
InChIKey=PZIFPMYXXCAOCC-JWQCQUIFSA-N
InChI=1S/C26H34O5S/c27-23(28)18-19-32-25(24(29)26(30)31)22-17-11-10-16-21(22)15-9-4-2-1-3-6-12-20-13-7-5-8-14-20/h5,7-8,10-11,13-14,16-17,24-25,29H,1-4,6,9,12,15,18-19H2,(H,27,28)(H,30,31)/t24-,25-/m1/s1
Molecular Formula | C26H34O5S |
Molecular Weight | 458.61 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 2 / 2 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
Pobilukast is the Leukotriene D4 receptor antagonist. Pobilukast significantly attenuated the Salmonella enteritidis endotoxin-induced thrombocytopenia but had no effect on either the endotoxin-induced early leukopenia or late leukocytosis. Additionally, Pobilukast significantly reduced the endotoxin-induced hemoconcentration and improved survival to 30% at 48 hr. Pobilukast dose-dependently inhibited the immediate hemodynamic changes after leukotriene D4 (LTD4) injections. Pobilukast also attenuated the increase in vascular permeability and the prolonged decrease in CO, suggesting that the observed cardiac and vascular effects of LTs were mediated by stimulation of LT receptors. A shift toward the right of the dose-response curves to histamine with pobilukast compared to that with placebo in three subjects was demonstrated, whereas the active compound did not exhibit any protective effect against histamine in the remaining nine subjects. It was concluded that there is a leukotriene component to the bronchial responses to histamine in some, but not all, subjects. Pobilukast had been in phase II clinical trial for the treatment of asthma. However, this development was discontinued.
Originator
Approval Year
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 17:13:27 UTC 2023
by
admin
on
Sat Dec 16 17:13:27 UTC 2023
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Record UNII |
R2N8IH71HC
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Record Status |
Validated (UNII)
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Record Version |
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-
Download
Name | Type | Language | ||
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Official Name | English | ||
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Common Name | English | ||
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Common Name | English | ||
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Common Name | English |
Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C29712
Created by
admin on Sat Dec 16 17:13:28 UTC 2023 , Edited by admin on Sat Dec 16 17:13:28 UTC 2023
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Code System | Code | Type | Description | ||
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100000081934
Created by
admin on Sat Dec 16 17:13:28 UTC 2023 , Edited by admin on Sat Dec 16 17:13:28 UTC 2023
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PRIMARY | |||
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C96710
Created by
admin on Sat Dec 16 17:13:28 UTC 2023 , Edited by admin on Sat Dec 16 17:13:28 UTC 2023
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PRIMARY | |||
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CHEMBL22776
Created by
admin on Sat Dec 16 17:13:28 UTC 2023 , Edited by admin on Sat Dec 16 17:13:28 UTC 2023
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PRIMARY | |||
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7179
Created by
admin on Sat Dec 16 17:13:28 UTC 2023 , Edited by admin on Sat Dec 16 17:13:28 UTC 2023
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PRIMARY | |||
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C052393
Created by
admin on Sat Dec 16 17:13:28 UTC 2023 , Edited by admin on Sat Dec 16 17:13:28 UTC 2023
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PRIMARY | |||
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107023-41-6
Created by
admin on Sat Dec 16 17:13:28 UTC 2023 , Edited by admin on Sat Dec 16 17:13:28 UTC 2023
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PRIMARY | |||
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60842
Created by
admin on Sat Dec 16 17:13:28 UTC 2023 , Edited by admin on Sat Dec 16 17:13:28 UTC 2023
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PRIMARY | |||
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R2N8IH71HC
Created by
admin on Sat Dec 16 17:13:28 UTC 2023 , Edited by admin on Sat Dec 16 17:13:28 UTC 2023
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PRIMARY | |||
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SUB09961MIG
Created by
admin on Sat Dec 16 17:13:28 UTC 2023 , Edited by admin on Sat Dec 16 17:13:28 UTC 2023
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PRIMARY |
Related Record | Type | Details | ||
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SALT/SOLVATE -> PARENT |
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TARGET -> INHIBITOR |
Ki
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SALT/SOLVATE -> PARENT |
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SALT/SOLVATE -> PARENT |
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Related Record | Type | Details | ||
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ACTIVE MOIETY |
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