IMIGLIPTIN DIHYDROCHLORIDE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C21H24N6O.2ClH
Molecular Weight	449.377
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.Cl.CN1C(=O)N(CC2=C(C=CC=C2)C#N)C3=C1N=C(C)C=C3N4CCC[C@@H](N)C4

InChI

InChIKey=TYFRVIKMTJPQNF-ZEECNFPPSA-N

InChI=1S/C21H24N6O.2ClH/c1-14-10-18(26-9-5-8-17(23)13-26)19-20(24-14)25(2)21(28)27(19)12-16-7-4-3-6-15(16)11-22;;/h3-4,6-7,10,17H,5,8-9,12-13,23H2,1-2H3;2*1H/t17-;;/m1../s1

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C21H24N6O
Molecular Weight	376.4549
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Tue Apr 01 18:19:16 GMT 2025` Edited by `admin` on `Tue Apr 01 18:19:16 GMT 2025`
Record UNII	R2DSA9X1S7
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

2-((7-((3R)-3-AMINO-1-PIPERIDYL)-3,5-DIMETHYL-2-OXO-IMIDAZO(4,5-B)PYRIDIN-1-YL)METHYL)BENZONITRILE DIHYDROCHLORIDE

Preferred Name

English

IMIGLIPTIN DIHYDROCHLORIDE

Common Name

English

BENZONITRILE, 2-((7-((3R)-3-AMINO-1-PIPERIDINYL)-2,3-DIHYDRO-3,5-DIMETHYL-2-OXO-1H-IMIDAZO(4,5-B)PYRIDIN-1-YL)METHYL)-, HYDROCHLORIDE (1:2)

Systematic Name

English

Code System Code Type Description

FDA UNII

R2DSA9X1S7

Created by admin on Tue Apr 01 18:19:16 GMT 2025 , Edited by admin on Tue Apr 01 18:19:16 GMT 2025

PRIMARY

PUBCHEM

71475850

Created by admin on Tue Apr 01 18:19:16 GMT 2025 , Edited by admin on Tue Apr 01 18:19:16 GMT 2025

PRIMARY

MANUFACTURER PRODUCT INFORMATION

IMIGLIPTIN DIHYDROCHLORIDE

Created by admin on Tue Apr 01 18:19:16 GMT 2025 , Edited by admin on Tue Apr 01 18:19:16 GMT 2025

PRIMARY

CAS Number: 1314944-07-4(Imigliptin); Chemical Name: Imigliptin Dihydrochloride; Synonyms: Imigliptin Dihydrochloride; CMNumber: CMO20163489; Molecular Formula: C21H24N6O.2HCl; Formula Weight: 449.38

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Related Record Type Details


					R2DSA9X1S7

IMIGLIPTIN DIHYDROCHLORIDE

ACTIVE MOIETY

Comments:

Drug: Imigliptin(Primary); Indication: Type 2 diabetes mellitus; Focus: Adverse reaction, First in man; Sponsor: Sihuan Pharmaceutical Holdings Group; Most Recent Event: 12 Nov 2014 New trial record


					R2DSA9X1S7

IMIGLIPTIN DIHYDROCHLORIDE

ACTIVE MOIETY

Comments:

After receiving Phase I clinical trial approval of the new drug from CFDA in 2013, Shandong XuanZhu has actively cooperated with the preeminent Peking Union Medical College Hospital (the Hospital) to conduct the Phase I clinical trials, and the clinical trials Phase I (Ia, Ib , Ic) have been completed in early 2015. The Phase I clinical trial of Imigliptin Dihydrochloride shows that the new drug were safe and well tolerated in healthy volunteers and type 2 diabetes patients without serious or severe adverse events. Imigliptin Hydrochloride demonstrated good pharmacokinetic / pharmacodynamic (PK/PD) characteristics and exhibited dose-proportional plasma exposure which further validated the potent and long duration inhibition of DPP-4 by Imigliptin. This well designed and executed phase I clinical trial reached our study goal, thus warranting further studies of its long-term safety and efficacy in phase II/III clinic trials.