CHLORAZEPAM

US Previously Marketed

First approved in 1975

Details

Stereochemistry	ACHIRAL
Molecular Formula	C16H13ClN2O.C2H3Cl3O2
Molecular Weight	450.143
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC(O)C(Cl)(Cl)Cl.CN1C2=CC=C(Cl)C=C2C(=NCC1=O)C3=CC=CC=C3

InChI

InChIKey=SDWAACKJISOIGZ-UHFFFAOYSA-N

InChI=1S/C16H13ClN2O.C2H3Cl3O2/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11;3-2(4,5)1(6)7/h2-9H,10H2,1H3;1,6-7H

HIDE SMILES / InChI

Molecular Formula	C2H3Cl3O2
Molecular Weight	165.403
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C16H13ClN2O
Molecular Weight	284.74
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

C_max

Value	Dose	Co-administered	Analyte	Population
10.4 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/4828698/	2 mg single, oral dose: 2 mg route of administration: Oral experiment type: SINGLE co-administered:		CHLORAZEPAM plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED

AUC

Value	Dose	Co-administered	Analyte	Population
242 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/4828698/	2 mg single, oral dose: 2 mg route of administration: Oral experiment type: SINGLE co-administered:		CHLORAZEPAM plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED

T_1/2

Value	Dose	Co-administered	Analyte	Population
26.4 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/4828698/	2 mg single, oral dose: 2 mg route of administration: Oral experiment type: SINGLE co-administered:		CHLORAZEPAM plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED

Sourcing

Vendor/Aggregator	ID	URL
ABI Chem	AC1MJ2VA
PubChem	3084599	https://pubchem.ncbi.nlm.nih.gov/compound/3084599

Substance Class	Chemical Created by `admin` on `Sat Dec 16 09:59:22 GMT 2023` Edited by `admin` on `Sat Dec 16 09:59:22 GMT 2023`
Record UNII	R14J9HX8JT
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CHLORAZEPAM

Common Name

English

CLORAZEPAT

Brand Name

English

1,1-ETHANEDIOL, 2,2,2-TRICHLORO-, COMPD. WITH 7-CHLORO-1,3-DIHYDRO-1-METHYL-5-PHENYL-2H-1,4-BENZODIAZEPIN-2-ONE (1:1)

Systematic Name

English

2H-1,4-BENZODIAZEPIN-2-ONE, 7-CHLORO-1,3-DIHYDRO-1-METHYL-5-PHENYL-, COMPD. WITH 2,2,2-TRICHLORO-1,1-ETHANEDIOL (1:1)

Systematic Name

English

Chlorazepam [WHO-DD]

Common Name

English

CHLORAL HYDRATE-DIAZEPAM (1:1)

Systematic Name

English

Code System Code Type Description

ECHA (EC/EINECS)

252-308-1