MORNIFLUMATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C19H20F3N3O3
Molecular Weight	395.3756
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

FC(F)(F)C1=CC=CC(NC2=C(C=CC=N2)C(=O)OCCN3CCOCC3)=C1

InChI

InChIKey=LDXSPUSKBDTEKA-UHFFFAOYSA-N

InChI=1S/C19H20F3N3O3/c20-19(21,22)14-3-1-4-15(13-14)24-17-16(5-2-6-23-17)18(26)28-12-9-25-7-10-27-11-8-25/h1-6,13H,7-12H2,(H,23,24)

HIDE SMILES / InChI

Molecular Formula	C19H20F3N3O3
Molecular Weight	395.3756
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1796197 | https://www.ncbi.nlm.nih.gov/pubmed/25921871

Morniflumate is a non-steroidal anti-inflammatory drug and represent as a beta-morpholinoethyl ester of niflumic acid, which is rapidly hydrolyzed in the plasma, releasing the free acidic form, the molecule responsible for the pharmacological effects. It was shown, that morniflumate was effective in the treatment of chronic recurring bronchitis and inhibited cyclooxygenase-1, 2 (COX-1, 2). Morniflumate has a 30-year history of clinical use, particularly for the treatment of pain associated with pediatric ear-nose-throat (ENT) infection. In addition, it appears to be a valid and well-tolerated alternative to other NSAIDs, or to antibiotics, for the treatment of pain and other symptoms of soft tissue inflammation.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Cyclooxygenase 89 Target ID: CHEMBL2094253 Sources: https://www.ncbi.nlm.nih.gov/pubmed/27841153	Inhibitor 8504

Conditions

Condition	Modality	Highest Phase	Product
Chronic recurring bronchitis 1 Sources: https://www.ncbi.nlm.nih.gov/pubmed/1796197	Primary	Phase II 1147	Unknown Approved Use Unknown
Paediatric ear-nose-throat (ENT) infection 1 Sources: https://www.ncbi.nlm.nih.gov/pubmed/25921871	Palliative	Not Provided 511	Unknown Approved Use Unknown
Soft tissue inflammation 1 Sources: https://www.ncbi.nlm.nih.gov/pubmed/25921871	Palliative	Not Provided 511	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method.	2010-12	21818443
Effects of perioperative intravenous low dose of ketamine on postoperative analgesia in children.	2010-01	19535988
Drug use in children: cohort study in three European countries.	2008-11-24	19029175
Acute regulation of the SLC26A3 congenital chloride diarrhoea anion exchanger (DRA) expressed in Xenopus oocytes.	2003-05-15	12651923
Retrospective analysis of drug-induced urticaria and angioedema: a survey of 2287 patients.	2001-11	11792017
Reactive haemophagocytic syndrome in children with inflammatory disorders. A retrospective study of 24 patients.	2001-11	11709613
Modulation of arachidonic acid metabolism by orally administered morniflumate in man.	1991-07	1659152
[A new anti-inflammatory-analgesic-antipyretic, morniflumate, in the treatment of chronic recurring bronchitis].	1991-02-01	1796197
A gastroprotective anti-inflammatory agent: the beta-morpholinoethyl ester of niflumic acid (morniflumate).	1984-02	6608862

Patents

Sample Use Guides

In Vivo Use Guide

Comparative pharmacokinetic and bioequivalence evaluation of two formulations of morniflumate 350-mg tablets: single dose of 350-mg tablet

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:05:21 GMT 2025` Edited by `admin` on `Mon Mar 31 18:05:21 GMT 2025`
Record UNII	R133MWH7X1
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

NIFLUMIC ACID .BETA.-MORPHOLINOETHYL ESTER

Preferred Name

English

MORNIFLUMATE

Official Name

English

NIFLUMIC ACID .BETA.-MORPHOLINOETHYL ESTER [MI]

Common Name

English

morniflumate [INN]

Common Name

English

MORNIFLUMATE [MART.]

Common Name

English

MORNIFLUMATE [USAN]

Common Name

English

3-PYRIDINECARBOXYLIC ACID, 2-((3-(TRIFLUOROMETHYL)PHENYL)AMINO)-, 2-(4-MORPHOLINYLETHYL) ESTER

Common Name

English

UP-164

Code

English

UP 164

Code

English

Morniflumate [WHO-DD]

Common Name

English

2-MORPHOLINOETHYL 2-(A,A,A-TRIFLUORO-M-TOLUIDINO)NICOTINATE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C28394