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Details

Stereochemistry ACHIRAL
Molecular Formula C19H20F3N3O3
Molecular Weight 395.3756
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MORNIFLUMATE

SMILES

FC(F)(F)C1=CC(NC2=NC=CC=C2C(=O)OCCN3CCOCC3)=CC=C1

InChI

InChIKey=LDXSPUSKBDTEKA-UHFFFAOYSA-N
InChI=1S/C19H20F3N3O3/c20-19(21,22)14-3-1-4-15(13-14)24-17-16(5-2-6-23-17)18(26)28-12-9-25-7-10-27-11-8-25/h1-6,13H,7-12H2,(H,23,24)

HIDE SMILES / InChI

Molecular Formula C19H20F3N3O3
Molecular Weight 395.3756
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Morniflumate is a non-steroidal anti-inflammatory drug and represent as a beta-morpholinoethyl ester of niflumic acid, which is rapidly hydrolyzed in the plasma, releasing the free acidic form, the molecule responsible for the pharmacological effects. It was shown, that morniflumate was effective in the treatment of chronic recurring bronchitis and inhibited cyclooxygenase-1, 2 (COX-1, 2). Morniflumate has a 30-year history of clinical use, particularly for the treatment of pain associated with pediatric ear-nose-throat (ENT) infection. In addition, it appears to be a valid and well-tolerated alternative to other NSAIDs, or to antibiotics, for the treatment of pain and other symptoms of soft tissue inflammation.

Approval Year

Targets

Primary TargetPharmacologyConditionPotency

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown
Palliative
Unknown
Palliative
Unknown

PubMed

Patents

Sample Use Guides

In Vivo Use Guide
Comparative pharmacokinetic and bioequivalence evaluation of two formulations of morniflumate 350-mg tablets: single dose of 350-mg tablet
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Record UNII
R133MWH7X1
Record Status Validated (UNII)
Record Version