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Details

Stereochemistry ABSOLUTE
Molecular Formula C53H72N2O12
Molecular Weight 929.145
Optical Activity UNSPECIFIED
Defined Stereocenters 4 / 4
E/Z Centers 0
Charge 2

SHOW SMILES / InChI
Structure of CISATRACURIUM

SMILES

COC1=CC=C(C[C@@H]2C3=CC(OC)=C(OC)C=C3CC[N@+]2(C)CCC(=O)OCCCCCOC(=O)CC[N@@+]4(C)CCC5=C(C=C(OC)C(OC)=C5)[C@H]4CC6=CC=C(OC)C(OC)=C6)C=C1OC

InChI

InChIKey=YXSLJKQTIDHPOT-LJCJQEJUSA-N
InChI=1S/C53H72N2O12/c1-54(22-18-38-32-48(62-7)50(64-9)34-40(38)42(54)28-36-14-16-44(58-3)46(30-36)60-5)24-20-52(56)66-26-12-11-13-27-67-53(57)21-25-55(2)23-19-39-33-49(63-8)51(65-10)35-41(39)43(55)29-37-15-17-45(59-4)47(31-37)61-6/h14-17,30-35,42-43H,11-13,18-29H2,1-10H3/q+2/t42-,43-,54-,55-/m1/s1

HIDE SMILES / InChI
Molecular Formula C53H72N2O12
Molecular Weight 929.145
Charge 2
Count
Stereochemistry MIXED
Additional Stereochemistry No
Defined Stereocenters 2 / 4
E/Z Centers 0
Optical Activity UNSPECIFIED

Description
Curator's Comment: description was created based on several sources, including www.ncbi.nlm.nih.gov/pubmed/9349062

Cisatracurium is a cis-cis isomer of atracurium and five time as potent as atracurium. The drug is approved by FDA and marketed under the name Nimbex. It is indicated as an adjunct to general anesthesia, to facilitate tracheal intubation, and to provide skeletal muscle relaxation due to its antagonistic properties toward nicotinic acetylcholine receptors.

Originator

Burroughs Wellcome Fund
41
Sources: ISBN-13: 978-1461484400
Curator's Comment: Now part of GlaxoSmithKline.

Approval Year

1995
203
Targets

Targets

Primary TargetPharmacologyConditionPotency
Antagonist
2849
 54.0 nM [IC50]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
Approved
8583
NIMBEX

Approved Use

Cisatracurium besylate injection is an intermediate-onset/intermediate-duration neuromuscular blocking agent indicated for inpatients and outpatients as an adjunct to general anesthesia, to facilitate tracheal intubation, and to provide skeletal muscle relaxation during surgery or mechanical ventilation in the ICU.

Launch Date

1995
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
2129.97 ng/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/35065599/
0.2 mg/kg single, intravenous
dose: 0.2 mg/kg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
CISATRACURIUM plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
16.6 μg × min/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/8688259/
0.1 mg/kg single, intravenous
dose: 0.1 mg/kg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
CISATRACURIUM plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
19.1 μg × min/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/8688259/
0.1 mg/kg single, intravenous
dose: 0.1 mg/kg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
CISATRACURIUM plasma
Homo sapiens
population: UNKNOWN
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
1394.04 ng × h/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/35065599/
0.2 mg/kg single, intravenous
dose: 0.2 mg/kg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
CISATRACURIUM plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
22 min
DRUG LABEL
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/20551Orig1s026lbl.pdf
0.1 mg/kg 1 times / day steady-state, intravenous
dose: 0.1 mg/kg
route of administration: Intravenous
experiment type: STEADY-STATE
co-administered:
CISATRACURIUM plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: UNKNOWN
food status: UNKNOWN
24.4 min
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/8688259/
0.1 mg/kg single, intravenous
dose: 0.1 mg/kg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
CISATRACURIUM plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
23.5 min
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/8688259/
0.1 mg/kg single, intravenous
dose: 0.1 mg/kg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
CISATRACURIUM plasma
Homo sapiens
population: UNKNOWN
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
29.44 min
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/35065599/
0.2 mg/kg single, intravenous
dose: 0.2 mg/kg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
CISATRACURIUM plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
Sourcing

Sourcing

Vendor/AggregatorIDURL
ChEBI
CHEBI:140621
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:140621
ZINC
ZINC000238809664
http://zinc15.docking.org/substances/ZINC000238809664
PubMed

PubMed

TitleDatePubMed
Prolonged weakness after cisatracurium infusion: a case report.
1998 Jul
Severe anaphylactic reaction to cisatracurium.
1999 Feb
Complete recovery from prolonged cardiac arrest following self-administration of cisatracurium.
2005 Jan
Prevention of succinylcholine-induced fasciculation and myalgia: a meta-analysis of randomized trials.
2005 Oct
Distinct pharmacologic properties of neuromuscular blocking agents on human neuronal nicotinic acetylcholine receptors: a possible explanation for the train-of-four fade.
2006 Sep
Acute coronary syndrome in cisatracurium-induced anaphylactic shock: Kounis syndrome.
2008 Dec
Patents

Patents

EP2283005 A2
4
US20110185796 A1
4

Sample Use Guides

In Vivo Use Guide
The recommended initial doses is 0.2 mg/kg, however it should be individualized. A dose of 0.03 mg/kg is recommended for maintenance of neuromuscular block during prolonged surgical procedures.
Route of Administration: Intravenous
In Vitro Use Guide
Human umbilical vein endothelial cells were incubated with 0, 0.96, 3.2, 9.6, 32, and 96 microM of cisatracurium for 72 h and the drug (3.2 microM) decreased the cell count to 50% (SD, 8.6%).
Substance Class Chemical
Created
by admin
on Mon Mar 31 18:07:34 GMT 2025
Edited
by admin
on Mon Mar 31 18:07:34 GMT 2025
Record UNII
QX62KLI41N
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CISATRACURIUM ION
Preferred Name English
CISATRACURIUM
VANDF   WHO-DD  
Common Name English
(1R,2R,1'R,2'R)-2,2'-(PENTANE-1,5-DIYLBIS(OXY(3-OXOPROPANE-3,1-DIYL)))BIS(1-(3,4-DIMETHOXYBENZYL)-6,7-DIMETHOXY-2-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINIUM)
Common Name English
CISATRACURIUM CATION
Common Name English
Cisatracurium [WHO-DD]
Common Name English
ISOQUINOLINIUM, 2,2'-(1,5-PENTANEDIYLBIS(OXY(3-OXO-3,1-PROPANEDIYL)))BIS(1-((3,4-DIMETHOXYPHENYL)METHYL)-1,2,3,4-TETRAHYDRO-6,7-DIMETHOXY-2-METHYL-, (1R,2R,1'R,2'R)-
Common Name English
CISATRACURIUM [VANDF]
Common Name English
Classification Tree Code System Code
NDF-RT N0000175720
Created by admin on Mon Mar 31 18:07:34 GMT 2025 , Edited by admin on Mon Mar 31 18:07:34 GMT 2025
WHO-ATC M03AC11
Created by admin on Mon Mar 31 18:07:34 GMT 2025 , Edited by admin on Mon Mar 31 18:07:34 GMT 2025
NDF-RT N0000175732
Created by admin on Mon Mar 31 18:07:34 GMT 2025 , Edited by admin on Mon Mar 31 18:07:34 GMT 2025
WHO-VATC QM03AC11
Created by admin on Mon Mar 31 18:07:34 GMT 2025 , Edited by admin on Mon Mar 31 18:07:34 GMT 2025
NCI_THESAURUS C66886
Created by admin on Mon Mar 31 18:07:34 GMT 2025 , Edited by admin on Mon Mar 31 18:07:34 GMT 2025
Code System Code Type Description
LACTMED
Cisatracurium
Created by admin on Mon Mar 31 18:07:34 GMT 2025 , Edited by admin on Mon Mar 31 18:07:34 GMT 2025
PRIMARY
DAILYMED
QX62KLI41N
Created by admin on Mon Mar 31 18:07:34 GMT 2025 , Edited by admin on Mon Mar 31 18:07:34 GMT 2025
PRIMARY
EPA CompTox
DTXSID60873212
Created by admin on Mon Mar 31 18:07:34 GMT 2025 , Edited by admin on Mon Mar 31 18:07:34 GMT 2025
PRIMARY
EVMPD
SUB01319MIG
Created by admin on Mon Mar 31 18:07:34 GMT 2025 , Edited by admin on Mon Mar 31 18:07:34 GMT 2025
PRIMARY
NCI_THESAURUS
C77365
Created by admin on Mon Mar 31 18:07:34 GMT 2025 , Edited by admin on Mon Mar 31 18:07:34 GMT 2025
PRIMARY
DRUG CENTRAL
661
Created by admin on Mon Mar 31 18:07:34 GMT 2025 , Edited by admin on Mon Mar 31 18:07:34 GMT 2025
PRIMARY
FDA UNII
QX62KLI41N
Created by admin on Mon Mar 31 18:07:34 GMT 2025 , Edited by admin on Mon Mar 31 18:07:34 GMT 2025
PRIMARY
CAS
96946-41-7
Created by admin on Mon Mar 31 18:07:34 GMT 2025 , Edited by admin on Mon Mar 31 18:07:34 GMT 2025
PRIMARY
MESH
C101584
Created by admin on Mon Mar 31 18:07:34 GMT 2025 , Edited by admin on Mon Mar 31 18:07:34 GMT 2025
PRIMARY
SMS_ID
100000087946
Created by admin on Mon Mar 31 18:07:34 GMT 2025 , Edited by admin on Mon Mar 31 18:07:34 GMT 2025
PRIMARY
DRUG BANK
DB00565
Created by admin on Mon Mar 31 18:07:34 GMT 2025 , Edited by admin on Mon Mar 31 18:07:34 GMT 2025
PRIMARY
RXCUI
319864
Created by admin on Mon Mar 31 18:07:34 GMT 2025 , Edited by admin on Mon Mar 31 18:07:34 GMT 2025
PRIMARY RxNorm
WIKIPEDIA
Cisatracurium
Created by admin on Mon Mar 31 18:07:34 GMT 2025 , Edited by admin on Mon Mar 31 18:07:34 GMT 2025
PRIMARY
PUBCHEM
62887
Created by admin on Mon Mar 31 18:07:34 GMT 2025 , Edited by admin on Mon Mar 31 18:07:34 GMT 2025
PRIMARY
Related Record Type Details
Structure of CISATRACURIUM BESYLATE
SALT/SOLVATE -> PARENT
Related Record Type Details
Structure of LAUDANOSINE
METABOLITE ACTIVE -> PARENT
MAJOR
Related Record Type Details
Structure of CISATRACURIUM
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Biological Half-life PHARMACOKINETIC
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
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