Details
Stereochemistry | ACHIRAL |
Molecular Formula | C18H14F3N3O4S |
Molecular Weight | 425.382 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CN1C(=O)NC(=O)N(C1=O)C2=CC(C)=C(OC3=CC=C(SC(F)(F)F)C=C3)C=C2
InChI
InChIKey=OCINXEZVIIVXFU-UHFFFAOYSA-N
InChI=1S/C18H14F3N3O4S/c1-10-9-11(24-16(26)22-15(25)23(2)17(24)27)3-8-14(10)28-12-4-6-13(7-5-12)29-18(19,20)21/h3-9H,1-2H3,(H,22,25,26)
Molecular Formula | C18H14F3N3O4S |
Molecular Weight | 425.382 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
CNS Activity
Sources: https://www.ncbi.nlm.nih.gov/pubmed/19205743
Curator's Comment: Toltrazuril and the metabolite were found in brain tissues of new born mice, indicating that passage of the blood-brain barrier occurred.
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: Enzymes of the respiratory cain |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Curative | Toltrazuril Approved UsePrevention and treatment of coccidiosis. Launch Date8.9138882E11 |
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Curative | Procox Approved UseProcox is used to treat dogs which are infected, or which the veterinary surgeon suspects of being infected, by two types of parasite at the same time, roundworms and coccidia. Launch Date1.30325755E12 |
PubMed
Title | Date | PubMed |
---|---|---|
Assessment of drugs against Cryptosporidium parvum using a simple in vitro screening method. | 1999 Sep 15 |
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[The influence of Baycox and Anticoc on the dynamics of Eimeria sp. course in calves]. | 2001 |
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Efficacy of toltrazuril against artificial infections with Eimeria bovis in calves. | 2003 Jul |
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Studies on the efficacy of toltrazuril, diclazuril and sulphadimidine against artificial infections with Isospora suis in piglets. | 2003 Jul |
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Effects of toltrazuril and ponazuril on the fine structure and multiplication of tachyzoites of the NC-1 strain of Neospora caninum (a synonym of Hammondia heydorni) in cell cultures. | 2004 Apr |
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Effects of toltrazuril and ponazuril on Hammondia heydorni (syn. Neospora caninum) infections in mice. | 2004 Apr |
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Field trial of a Caryospora species vaccine for controlling clinical coccidiosis in falcons. | 2005 Jan 29 |
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The efficacy and economic benefits of Supercox, a live anticoccidial vaccine in a commercial trial in broiler chickens in China. | 2006 Nov 30 |
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Controlling coccidiosis in piglets: the importance of the subclinical infection. | 2007 Jan |
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NcGRA2 as a molecular target to assess the parasiticidal activity of toltrazuril against Neospora caninum. | 2008 Aug |
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The value of plant extracts with antioxidant activity in attenuating coccidiosis in broiler chickens. | 2008 May 31 |
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An outbreak of cryptosporidiosis in a collection of Stone curlews (Burhinus oedicnemus) in Dubai. | 2008 Oct |
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Efficacy of toltrazuril (Baycox 5% suspension) in natural infections with pathogenic Eimeria spp. in housed lambs. | 2009 Apr |
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Haste makes waste: accelerated molt adversely affects the expression of melanin-based and depigmented plumage ornaments in house sparrows. | 2010 Dec 3 |
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Pharmacokinetics and improved bioavailability of toltrazuril after oral administration to rabbits. | 2010 Oct |
Patents
Sample Use Guides
Administration via drinking water at 25 mg/l over 48 h, or at 75 mg/l given for 8h per day for 2 consecutive days (turkeys and chickens). Treatment corresponds to a dose of approximately 7 mg/kg bw/day.
In dogs: the recommended minimum dose is 0.5 ml/kg bodyweight (bw), equivalent to 0.45 mg emodepside/kg bw and 9 mg toltrazuril/kg bw.
Route of Administration:
Oral
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC192392/
Anticoccidial drugs were evaluated for activity and for the development of resistance in a model of Toxoplasma gondii growing in human fibroblast cultures. 50% inhibitory concentration, in micrograms per milliliter for toltrazuril = 0.4.
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 17:31:44 UTC 2023
by
admin
on
Sat Dec 16 17:31:44 UTC 2023
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Record UNII |
QVZ3IAR3JS
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Record Status |
Validated (UNII)
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Record Version |
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-
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NCI_THESAURUS |
C277
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WHO-VATC |
QP51AJ01
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WHO-VATC |
QP52AX60
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EMA VETERINARY ASSESSMENT REPORTS |
PROCOX [AUTHORIZED]
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CHEMBL2104931
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Z-55
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759176
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TOLTRAZURIL
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69004-03-1
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C72601
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C036670
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1535930
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DTXSID90219063
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m10955
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