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Details

Stereochemistry ACHIRAL
Molecular Formula C18H14F3N3O4S
Molecular Weight 425.382
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TOLTRAZURIL

SMILES

CN1C(=O)NC(=O)N(C1=O)C2=CC(C)=C(OC3=CC=C(SC(F)(F)F)C=C3)C=C2

InChI

InChIKey=OCINXEZVIIVXFU-UHFFFAOYSA-N
InChI=1S/C18H14F3N3O4S/c1-10-9-11(24-16(26)22-15(25)23(2)17(24)27)3-8-14(10)28-12-4-6-13(7-5-12)29-18(19,20)21/h3-9H,1-2H3,(H,22,25,26)

HIDE SMILES / InChI

Molecular Formula C18H14F3N3O4S
Molecular Weight 425.382
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Toltrazuril (Baycox, Procox, Tolcox, Toltrazuril) is a veterinary drug approved in Europe for the treatment of parasitic infections caused by roundworms and coccidia. In dogs it is used in combination with emodepside (Procox).

CNS Activity

Curator's Comment: Toltrazuril and the metabolite were found in brain tissues of new born mice, indicating that passage of the blood-brain barrier occurred.

Originator

Curator's Comment: # Bayer

Approval Year

Targets

Targets

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
Toltrazuril

Approved Use

Prevention and treatment of coccidiosis.

Launch Date

8.9138882E11
Curative
Procox

Approved Use

Procox is used to treat dogs which are infected, or which the veterinary surgeon suspects of being infected, by two types of parasite at the same time, roundworms and coccidia.

Launch Date

1.30325755E12
PubMed

PubMed

TitleDatePubMed
Assessment of drugs against Cryptosporidium parvum using a simple in vitro screening method.
1999 Sep 15
[The influence of Baycox and Anticoc on the dynamics of Eimeria sp. course in calves].
2001
Efficacy of toltrazuril against artificial infections with Eimeria bovis in calves.
2003 Jul
Studies on the efficacy of toltrazuril, diclazuril and sulphadimidine against artificial infections with Isospora suis in piglets.
2003 Jul
Effects of toltrazuril and ponazuril on the fine structure and multiplication of tachyzoites of the NC-1 strain of Neospora caninum (a synonym of Hammondia heydorni) in cell cultures.
2004 Apr
Effects of toltrazuril and ponazuril on Hammondia heydorni (syn. Neospora caninum) infections in mice.
2004 Apr
Field trial of a Caryospora species vaccine for controlling clinical coccidiosis in falcons.
2005 Jan 29
The efficacy and economic benefits of Supercox, a live anticoccidial vaccine in a commercial trial in broiler chickens in China.
2006 Nov 30
Controlling coccidiosis in piglets: the importance of the subclinical infection.
2007 Jan
NcGRA2 as a molecular target to assess the parasiticidal activity of toltrazuril against Neospora caninum.
2008 Aug
The value of plant extracts with antioxidant activity in attenuating coccidiosis in broiler chickens.
2008 May 31
An outbreak of cryptosporidiosis in a collection of Stone curlews (Burhinus oedicnemus) in Dubai.
2008 Oct
Efficacy of toltrazuril (Baycox 5% suspension) in natural infections with pathogenic Eimeria spp. in housed lambs.
2009 Apr
Haste makes waste: accelerated molt adversely affects the expression of melanin-based and depigmented plumage ornaments in house sparrows.
2010 Dec 3
Pharmacokinetics and improved bioavailability of toltrazuril after oral administration to rabbits.
2010 Oct
Patents

Sample Use Guides

Administration via drinking water at 25 mg/l over 48 h, or at 75 mg/l given for 8h per day for 2 consecutive days (turkeys and chickens). Treatment corresponds to a dose of approximately 7 mg/kg bw/day. In dogs: the recommended minimum dose is 0.5 ml/kg bodyweight (bw), equivalent to 0.45 mg emodepside/kg bw and 9 mg toltrazuril/kg bw.
Route of Administration: Oral
Anticoccidial drugs were evaluated for activity and for the development of resistance in a model of Toxoplasma gondii growing in human fibroblast cultures. 50% inhibitory concentration, in micrograms per milliliter for toltrazuril = 0.4.
Substance Class Chemical
Created
by admin
on Sat Dec 16 17:31:44 UTC 2023
Edited
by admin
on Sat Dec 16 17:31:44 UTC 2023
Record UNII
QVZ3IAR3JS
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
TOLTRAZURIL
INN   MART.   MI   USAN  
USAN   INN  
Official Name English
TOLTRAZURIL COMPONENT OF PROCOX
Common Name English
toltrazuril [INN]
Common Name English
PROCOX COMPONENT TOLTRAZURIL
Brand Name English
BAY VI 9142
Code English
TOLTRAZURIL [EMA EPAR VETERINARY]
Common Name English
TOLTRAZURIL [MART.]
Common Name English
TOLTRAZURIL [USAN]
Common Name English
BAY-VI-9142
Code English
NSC-759176
Code English
TOLTRAZURIL [MI]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C277
Created by admin on Sat Dec 16 17:31:44 UTC 2023 , Edited by admin on Sat Dec 16 17:31:44 UTC 2023
WHO-VATC QP51AJ01
Created by admin on Sat Dec 16 17:31:44 UTC 2023 , Edited by admin on Sat Dec 16 17:31:44 UTC 2023
WHO-VATC QP52AX60
Created by admin on Sat Dec 16 17:31:44 UTC 2023 , Edited by admin on Sat Dec 16 17:31:44 UTC 2023
EMA VETERINARY ASSESSMENT REPORTS PROCOX [AUTHORIZED]
Created by admin on Sat Dec 16 17:31:44 UTC 2023 , Edited by admin on Sat Dec 16 17:31:44 UTC 2023
Code System Code Type Description
ChEMBL
CHEMBL2104931
Created by admin on Sat Dec 16 17:31:44 UTC 2023 , Edited by admin on Sat Dec 16 17:31:44 UTC 2023
PRIMARY
USAN
Z-55
Created by admin on Sat Dec 16 17:31:44 UTC 2023 , Edited by admin on Sat Dec 16 17:31:44 UTC 2023
PRIMARY
NSC
759176
Created by admin on Sat Dec 16 17:31:44 UTC 2023 , Edited by admin on Sat Dec 16 17:31:44 UTC 2023
PRIMARY
WIKIPEDIA
TOLTRAZURIL
Created by admin on Sat Dec 16 17:31:44 UTC 2023 , Edited by admin on Sat Dec 16 17:31:44 UTC 2023
PRIMARY
CAS
69004-03-1
Created by admin on Sat Dec 16 17:31:44 UTC 2023 , Edited by admin on Sat Dec 16 17:31:44 UTC 2023
PRIMARY
FDA UNII
QVZ3IAR3JS
Created by admin on Sat Dec 16 17:31:44 UTC 2023 , Edited by admin on Sat Dec 16 17:31:44 UTC 2023
PRIMARY
NCI_THESAURUS
C72601
Created by admin on Sat Dec 16 17:31:44 UTC 2023 , Edited by admin on Sat Dec 16 17:31:44 UTC 2023
PRIMARY
MESH
C036670
Created by admin on Sat Dec 16 17:31:44 UTC 2023 , Edited by admin on Sat Dec 16 17:31:44 UTC 2023
PRIMARY
SMS_ID
100000077767
Created by admin on Sat Dec 16 17:31:44 UTC 2023 , Edited by admin on Sat Dec 16 17:31:44 UTC 2023
PRIMARY
EVMPD
SUB11181MIG
Created by admin on Sat Dec 16 17:31:44 UTC 2023 , Edited by admin on Sat Dec 16 17:31:44 UTC 2023
PRIMARY
DAILYMED
QVZ3IAR3JS
Created by admin on Sat Dec 16 17:31:44 UTC 2023 , Edited by admin on Sat Dec 16 17:31:44 UTC 2023
PRIMARY
INN
5576
Created by admin on Sat Dec 16 17:31:44 UTC 2023 , Edited by admin on Sat Dec 16 17:31:44 UTC 2023
PRIMARY
PUBCHEM
68591
Created by admin on Sat Dec 16 17:31:44 UTC 2023 , Edited by admin on Sat Dec 16 17:31:44 UTC 2023
PRIMARY
RXCUI
1535930
Created by admin on Sat Dec 16 17:31:44 UTC 2023 , Edited by admin on Sat Dec 16 17:31:44 UTC 2023
PRIMARY RxNorm
EPA CompTox
DTXSID90219063
Created by admin on Sat Dec 16 17:31:44 UTC 2023 , Edited by admin on Sat Dec 16 17:31:44 UTC 2023
PRIMARY
MERCK INDEX
m10955
Created by admin on Sat Dec 16 17:31:44 UTC 2023 , Edited by admin on Sat Dec 16 17:31:44 UTC 2023
PRIMARY Merck Index
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