TOLTRAZURIL

Possibly Marketed Outside US

Details

Stereochemistry	ACHIRAL
Molecular Formula	C18H14F3N3O4S
Molecular Weight	425.382
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

CN1C(=O)NC(=O)N(C1=O)C2=CC(C)=C(OC3=CC=C(SC(F)(F)F)C=C3)C=C2

InChI

InChIKey=OCINXEZVIIVXFU-UHFFFAOYSA-N

InChI=1S/C18H14F3N3O4S/c1-10-9-11(24-16(26)22-15(25)23(2)17(24)27)3-8-14(10)28-12-4-6-13(7-5-12)29-18(19,20)21/h3-9H,1-2H3,(H,22,25,26)

HIDE SMILES / InChI

Molecular Formula	C18H14F3N3O4S
Molecular Weight	425.382
Charge	0
Count	MOL RATIO 1 MOL RATIO (average)

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description

Toltrazuril (Baycox, Procox, Tolcox, Toltrazuril) is a veterinary drug approved in Europe for the treatment of parasitic infections caused by roundworms and coccidia. In dogs it is used in combination with emodepside (Procox).

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Enzymes of the respiratory cain 1	Inhibitor 8,297

Conditions

Condition	Modality	Targets	Highest Phase	Product
Coccidiosis 45	Curative		Approved 8,429	Toltrazuril
Round worms 1	Curative		Approved 8,429	Procox

PubMed

Show entries

Title	Date	PubMed
[The influence of Baycox and Anticoc on the dynamics of Eimeria sp. course in calves].	2001	16888954
An explorative study to assess the efficacy of toltrazuril-sulfone (ponazuril) in calves experimentally infected with Neospora caninum.	2002 Oct 18	12437777
Vomiting, diarrhoea and inappetence in a young cat with hypoproteinaemia.	2002 Sep	12398315
Efficacy of toltrazuril against artificial infections with Eimeria bovis in calves.	2003 Jul	12928893
Clinical Hepatozoon canis infection in a dog in Turkey.	2004 Dec	15600273

Showing 1 to 5 of 23 entries

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Patents

Sample Use Guides

In Vivo Use Guide

Administration via drinking water at 25 mg/l over 48 h, or at 75 mg/l given for 8h per day for 2 consecutive days (turkeys and chickens). Treatment corresponds to a dose of approximately 7 mg/kg bw/day. In dogs: the recommended minimum dose is 0.5 ml/kg bodyweight (bw), equivalent to 0.45 mg emodepside/kg bw and 9 mg toltrazuril/kg bw.

Route of Administration: Oral

In Vitro Use Guide

Anticoccidial drugs were evaluated for activity and for the development of resistance in a model of Toxoplasma gondii growing in human fibroblast cultures. 50% inhibitory concentration, in micrograms per milliliter for toltrazuril = 0.4.