Mivocabtagene Autoleucel

Approval Year

Substance Class	Structurally Diverse Created by `admin` on `Wed Apr 02 17:49:40 GMT 2025` Edited by `admin` on `Wed Apr 02 17:49:40 GMT 2025`
Source Materials Class	ORGANISM
Source Materials Type	AUTOLOGOUS HUMAN
Source Materials State	LIVE GENETICALLY MODIFIED
Source Materials Parent	`G0T704E6Z3` HOMO SAPIENS WHOLE
Part	blood
Fraction Name	CD4+/CD8+ enriched T cells
Record UNII	QTE27WBS5A
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

autologous CD4+/CD8+ enriched T lymphocytes derived from leukapheresis material, transduced with a self-inactivating, non-replicating lentiviral vector encoding a CD19 targeting chimeric antigen receptor (CAR) comprising a CD8 alpha (CD8?) signal peptide

Preferred Name

English

Mivocabtagene Autoleucel

Official Name

English

mivocabtagene autoleucel [INN]

Common Name

English

Code System Code Type Description

FDA UNII

QTE27WBS5A

Created by admin on Wed Apr 02 17:49:40 GMT 2025 , Edited by admin on Wed Apr 02 17:49:40 GMT 2025

PRIMARY

INN

13488

Created by admin on Wed Apr 02 17:49:40 GMT 2025 , Edited by admin on Wed Apr 02 17:49:40 GMT 2025

PRIMARY

Related Record Type Details


					TYR224OK86

CD19 POSITIVE CELLS

TARGET->CYTOTOXIC T-CELL

Interaction Type:

IN-VITRO

Amount:

Related Record Type Details


					QTE27WBS5A

Mivocabtagene Autoleucel

ACTIVE MOIETY

Amount:

Agent Modifications

Modification Process	Modification Role	Modification Type	Fragment Name	Fragment ID
CULTURE	ACTIVATOR	BIOLOGICAL	HUMAN AB SERUM	S6RLS52G3S
CULTURE	ACTIVATOR	BIOLOGICAL	INTERLEUKIN-7 HUMAN RECOMBINANT	418XB47Y71
LENTIVIRAL TRANSFECTION	TRANSFECTION	BIOLOGICAL	Mivocabtagene autoleucel lentiviral vector	C3CKE5WGY4
CULTURE	EXPANSION	BIOLOGICAL	INTERLEUKIN-7 HUMAN RECOMBINANT	418XB47Y71

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
VECTOR EXPRESSED PROTEIN					Mivocabtagene autoleucel expressed human anti-CD19 CAR	VZY7HJ5FSB
INSERTED GENE EXPRESSION VECTOR					Mivocabtagene autoleucel transgene insert encoding the anti-CD19 CAR	VW2YVK95BV

Name	Property Type	Referenced Substance
ANTIGEN EXPRESSED	BIOLOGICAL	`2946IE3VYD` CD8

ANTIGEN EXPRESSED	BIOLOGICAL	`8OYI5QX0HL` T-CELL SURFACE GLYCOPROTEIN CD4