ARSTHINOL

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

First approved in 1952

First approved in 1952

Details

Stereochemistry	RACEMIC
Molecular Formula	C11H14AsNO3S2
Molecular Weight	347.285
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of ARSTHINOL

Structure Search

SMILES

CC(=O)NC1=C(O)C=CC(=C1)[As]2SCC(CO)S2

InChI

InChIKey=MRUDSZSRLQAPOG-UHFFFAOYSA-N

InChI=1S/C11H14AsNO3S2/c1-7(15)13-10-4-8(2-3-11(10)16)12-17-6-9(5-14)18-12/h2-4,9,14,16H,5-6H2,1H3,(H,13,15)

HIDE SMILES / InChI

Molecular Formula	C11H14AsNO3S2
Molecular Weight	347.285
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/23831266 | https://www.ncbi.nlm.nih.gov/pubmed/13138828

ARSTHINOL, an organoarsenical compound, is an antiprotozoal agent used for the treatment of mild or asymptomatic intestinal amebiasis. ARSTHINOL in complex with cyclodextrin displays an anticancer activity.

Approval Year

PubMed

PubMed

Title	Date	PubMed
The treatment of amebiasis with arsthinol (N.N.R) (balarsen).	1954 Jun	24543096
Arsthinol (balarsen), a new trivalent arsenical for the treatment of intestinal amebiasis and other intestinal protozoa.	1954 Mar	13138828
Intestinal amebiasis; incidence, symptoms, and treatment with arsthinol (balarsen).	1956 Feb 4	13278204
The antitumor effects of an arsthinol-cyclodextrin complex in a heterotopic mouse model of glioma.	2013 Nov	23831266

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:14:54 GMT 2023` Edited by `admin` on `Fri Dec 15 15:14:54 GMT 2023`
Record UNII	QNT09A162Y
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ARSTHINOL

Official Name

English

3-HYDROXYPROPYLENE ESTER OF 3-ACETAMIDO-4-HYDROXYDITHIOBENZENEARSONOUS ACID

Common Name

English

ARSTHINOL [MI]

Common Name

English

Arsthinol [WHO-DD]

Common Name

English

arsthinol [INN]

Common Name

English

Classification Tree Code System Code

WHO-ATC

P01AR01

Created by admin on Fri Dec 15 15:14:54 GMT 2023 , Edited by admin on Fri Dec 15 15:14:54 GMT 2023

WHO-VATC

QP51AD01

Created by admin on Fri Dec 15 15:14:54 GMT 2023 , Edited by admin on Fri Dec 15 15:14:54 GMT 2023

Code System Code Type Description

DRUG CENTRAL

3007

Created by admin on Fri Dec 15 15:14:54 GMT 2023 , Edited by admin on Fri Dec 15 15:14:54 GMT 2023

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FDA UNII

QNT09A162Y

Created by admin on Fri Dec 15 15:14:54 GMT 2023 , Edited by admin on Fri Dec 15 15:14:54 GMT 2023

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EPA CompTox

DTXSID40861753

Created by admin on Fri Dec 15 15:14:54 GMT 2023 , Edited by admin on Fri Dec 15 15:14:54 GMT 2023

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DRUG BANK

DB08928

Created by admin on Fri Dec 15 15:14:54 GMT 2023 , Edited by admin on Fri Dec 15 15:14:54 GMT 2023

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PUBCHEM

8414

Created by admin on Fri Dec 15 15:14:54 GMT 2023 , Edited by admin on Fri Dec 15 15:14:54 GMT 2023

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WIKIPEDIA

ARSTHINOL

Created by admin on Fri Dec 15 15:14:54 GMT 2023 , Edited by admin on Fri Dec 15 15:14:54 GMT 2023

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INN

240

Created by admin on Fri Dec 15 15:14:54 GMT 2023 , Edited by admin on Fri Dec 15 15:14:54 GMT 2023

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EVMPD

SUB05572MIG

Created by admin on Fri Dec 15 15:14:54 GMT 2023 , Edited by admin on Fri Dec 15 15:14:54 GMT 2023

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SMS_ID

100000086623

Created by admin on Fri Dec 15 15:14:54 GMT 2023 , Edited by admin on Fri Dec 15 15:14:54 GMT 2023

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NCI_THESAURUS

C76411

Created by admin on Fri Dec 15 15:14:54 GMT 2023 , Edited by admin on Fri Dec 15 15:14:54 GMT 2023

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MESH

C546471

Created by admin on Fri Dec 15 15:14:54 GMT 2023 , Edited by admin on Fri Dec 15 15:14:54 GMT 2023

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CAS

119-96-0

Created by admin on Fri Dec 15 15:14:54 GMT 2023 , Edited by admin on Fri Dec 15 15:14:54 GMT 2023

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MERCK INDEX

m2072

Created by admin on Fri Dec 15 15:14:54 GMT 2023 , Edited by admin on Fri Dec 15 15:14:54 GMT 2023

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Merck Index

ECHA (EC/EINECS)

204-361-7

Created by admin on Fri Dec 15 15:14:54 GMT 2023 , Edited by admin on Fri Dec 15 15:14:54 GMT 2023

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ENANTIOMER -> RACEMATE

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					QNT09A162Y

ARSTHINOL

ACTIVE MOIETY