TEPIRINDOLE HYDROCHLORIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C16H19ClN2.ClH
Molecular Weight	311.249
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.CCCN1CCC(=CC1)C2=CNC3=C2C=C(Cl)C=C3

InChI

InChIKey=LQNYZAQTPONBOP-UHFFFAOYSA-N

InChI=1S/C16H19ClN2.ClH/c1-2-7-19-8-5-12(6-9-19)15-11-18-16-4-3-13(17)10-14(15)16;/h3-5,10-11,18H,2,6-9H2,1H3;1H

HIDE SMILES / InChI

Molecular Formula	C16H19ClN2
Molecular Weight	274.788
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2342229 | Annual Reports in Medicinal Chemistry, V. 22, p. 6, retrieved from: https://books.google.ru/books?id=oJeTSJveeuAC&pg=PA6&lpg=PA6&dq=HR-592+TEPIRINDOLE&source=bl&ots=9bsWMHLDKh&sig=ACfU3U152dpzs8c_kfJ3eL-3VSIz13dd8w&hl=ru&sa=X&ved=2ahUKEwjL_IXp-qnjAhVCxMQBHdlCCgEQ6AEwA3oECAgQAQ#v=onepage&q=HR-592%20TEPIRINDOLE&f=false

Tepirindole (also known as HR-592), an indole derivative has a high affinity for DA, 5-HT and NE receptors but has little properties to cause catalepsy. Animal experiments have shown that this compound could alleviate the adverse effect of neuroleptics such as haloperidol. Information about the current development of tepirindole is not available.

Approval Year

PubMed

Title	Date	PubMed
Behavioral effects of HR-592, a new derivative of indole.	1990 Apr	2342229
Effects of HR-592, a new derivative of indole, on conditioned behavior.	1990 Feb	2330844

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:18:33 GMT 2023` Edited by `admin` on `Fri Dec 15 15:18:33 GMT 2023`
Record UNII	QIM3OH6KNF
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TEPIRINDOLE HYDROCHLORIDE

Common Name

English

HR-592

Code

English

1H-INDOLE, 5-CHLORO-3-(1,2,3,6-TETRAHYDRO-1-PROPYL-4-PYRIDINYL)-, HYDROCHLORIDE (1:1)

Systematic Name

English

RU-27592 HYDROCHLORIDE

Code

English

Code System Code Type Description

PUBCHEM

3055747