ICOMIDOCHOLIC ACID

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C44H79NO5
Molecular Weight	702.1018
Optical Activity	UNSPECIFIED
Defined Stereocenters	11 / 11
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]1(CC[C@@]2([H])[C@]3([H])[C@H](O)C[C@]4([H])C[C@H](CC[C@]4(C)[C@@]3([H])C[C@H](O)[C@]12C)NC(=O)CCCCCCCCCCCCCCCCCCC)[C@H](C)CCC(O)=O

InChI

InChIKey=SHKXZIQNFMOPBS-OOMQYRRCSA-N

InChI=1S/C44H79NO5/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-40(48)45-34-27-28-43(3)33(29-34)30-38(46)42-36-25-24-35(32(2)23-26-41(49)50)44(36,4)39(47)31-37(42)43/h32-39,42,46-47H,5-31H2,1-4H3,(H,45,48)(H,49,50)/t32-,33+,34+,35-,36+,37+,38-,39+,42+,43+,44-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C44H79NO5
Molecular Weight	702.1018
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	10 / 11
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/24815326 | https://www.ncbi.nlm.nih.gov/pubmed/29159325 | http://galmedpharma.investorroom.com/2019-04-09-Galmed-Pharmaceuticals-Announces-Successful-Completion-of-End-of-Phase-2-Meeting-With-FDA-and-Plan-for-Start-of-Phase-3

Approval Year

PubMed

Title	Date	PubMed
The fatty acid-bile acid conjugate Aramchol reduces liver fat content in patients with nonalcoholic fatty liver disease.	2014 Dec	24815326
Role of Aramchol in steatohepatitis and fibrosis in mice.	2017 Nov	29159325
Current and emerging pharmacological therapy for non-alcoholic fatty liver disease.	2017 Nov 14	29204050

Patents

Sample Use Guides

In Vivo Use Guide

Patients were given Aramchol (100 or 300 mg) or placebo once daily for 3 months

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Sat Dec 16 10:59:14 UTC 2023` Edited by `admin` on `Sat Dec 16 10:59:14 UTC 2023`
Record UNII	QE1Q24M65Y
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ICOMIDOCHOLIC ACID

Official Name

English

Arachidyl amido cholanoic acid [WHO-DD]

Common Name

English

CHOLAN-24-OIC ACID, 7,12-DIHYDROXY-3-((1-OXOEICOSYL)AMINO)-, (3.BETA.,5.BETA.,7.ALPHA.,12.ALPHA.)-

Systematic Name

English

C20-FABAC

Common Name

English

ARAMCHOL

Common Name

English

(3.BETA.)-ARACHIDYLAMIDO-7.ALPHA.,12.ALPHA.-DIHYDROXY-5.BETA.-CHOLAN-24-OIC ACID

Systematic Name

English

icomidocholic acid [INN]

Common Name

English

Code System Code Type Description

EPA CompTox

DTXSID90179395