ICOMIDOCHOLIC ACID

Investigational

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C44H79NO5
Molecular Weight	702.1018
Optical Activity	UNSPECIFIED
Defined Stereocenters	11 / 11
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCCCCCCCCCCCCCCCCCC(=O)N[C@H]1CC[C@@]2(C)[C@H](C[C@@H](O)[C@H]3[C@@H]4CC[C@H]([C@H](C)CCC(O)=O)[C@@]4(C)[C@@H](O)C[C@H]23)C1

InChI

InChIKey=SHKXZIQNFMOPBS-OOMQYRRCSA-N

InChI=1S/C44H79NO5/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-40(48)45-34-27-28-43(3)33(29-34)30-38(46)42-36-25-24-35(32(2)23-26-41(49)50)44(36,4)39(47)31-37(42)43/h32-39,42,46-47H,5-31H2,1-4H3,(H,45,48)(H,49,50)/t32-,33+,34+,35-,36+,37+,38-,39+,42+,43+,44-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C44H79NO5
Molecular Weight	702.1018
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	11 / 11
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/24815326 | https://www.ncbi.nlm.nih.gov/pubmed/29159325 | http://galmedpharma.investorroom.com/2019-04-09-Galmed-Pharmaceuticals-Announces-Successful-Completion-of-End-of-Phase-2-Meeting-With-FDA-and-Plan-for-Start-of-Phase-3

Approval Year

PubMed

Title	Date	PubMed
Current and emerging pharmacological therapy for non-alcoholic fatty liver disease.	2017-11-14	29204050
Role of Aramchol in steatohepatitis and fibrosis in mice.	2017-11	29159325
The fatty acid-bile acid conjugate Aramchol reduces liver fat content in patients with nonalcoholic fatty liver disease.	2014-12	24815326

Patents

Sample Use Guides

In Vivo Use Guide

Patients were given Aramchol (100 or 300 mg) or placebo once daily for 3 months

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Mon Mar 31 23:33:24 GMT 2025` Edited by `admin` on `Mon Mar 31 23:33:24 GMT 2025`
Record UNII	QE1Q24M65Y
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ICOMIDOCHOLIC ACID

Official Name

English

ARAMCHOL

Preferred Name

English

Arachidyl amido cholanoic acid [WHO-DD]

Common Name

English

CHOLAN-24-OIC ACID, 7,12-DIHYDROXY-3-((1-OXOEICOSYL)AMINO)-, (3.BETA.,5.BETA.,7.ALPHA.,12.ALPHA.)-

Systematic Name

English

C20-FABAC

Common Name

English

(3.BETA.)-ARACHIDYLAMIDO-7.ALPHA.,12.ALPHA.-DIHYDROXY-5.BETA.-CHOLAN-24-OIC ACID

Systematic Name

English

icomidocholic acid [INN]

Common Name

English

Code System Code Type Description

EPA CompTox

DTXSID90179395