Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C18H25N3O5 |
| Molecular Weight | 363.4082 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
NCCCC[C@H](N[C@H]1CCC2=C(C=CC=C2)N(CC(O)=O)C1=O)C(O)=O
InChI
InChIKey=AXTCRUUITQKBAV-KBPBESRZSA-N
InChI=1S/C18H25N3O5/c19-10-4-3-6-14(18(25)26)20-13-9-8-12-5-1-2-7-15(12)21(17(13)24)11-16(22)23/h1-2,5,7,13-14,20H,3-4,6,8-11,19H2,(H,22,23)(H,25,26)/t13-,14-/m0/s1
| Molecular Formula | C18H25N3O5 |
| Molecular Weight | 363.4082 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Libenzapril is a long-acting, small polar angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. Libenzapril competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Libenzapril also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow. Both libenzapril and water transport was found to be significantly higher (about two- to five-fold) in six of the seven different brain regions in hypertensive rats as compared to the normotensive controls.
CNS Activity
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Direct determination of angiotensin-converting enzyme inhibitors in plasma by radioenzymatic assay. | 1987 Apr |
|
| Additive beneficial effects of two inhibitors of vasoconstrictor mediators in acute myocardial ischemia. | 1987 Jul |
|
| Potentiation of the protective effects of a converting enzyme inhibitor and a thromboxane synthetase inhibitor in hemorrhagic shock. | 1987 Jul |
|
| Determination of CGS 16617 and stable isotope-labeled CGS 16617, an angiotensin-converting enzyme inhibitor, in human plasma by gas chromatography/mass spectrometry. | 1991 Jan |
|
| Inhibition of thromboxane synthetase potentiates the antihypertensive action of an angiotensin-converting enzyme inhibitor by a prostaglandin-dependent but kinin-independent mechanism. | 1991 Oct |
|
| Patterns of renal function in hypertension due to unilateral renal artery occlusion. | 1992 |
|
| Effect of chronic hypertension on the blood-brain barrier permeability of libenzapril. | 1992 Feb |
|
| Time-dependent effect of the angiotensin converting enzyme inhibitor, abutapril, on voluntary alcohol intake in the rat. | 1992 May |
|
| Increased blood-brain barrier permeability of amino acids in chronic hypertension. | 1993 |
|
| Rapid reversal of angiotensin I-induced contractions in rat carotid arteries after acute and chronic treatment with the angiotensin-converting enzyme inhibitor, 3-[(5-amino-1-carboxy-1S-pentyl)amino]2,3,4,5-tetrahydro-2-oxo- 3S-1H-1-benzazepena-1-acetic acid (CGS 16617). | 1993 Dec |
|
| Inhibition of angiotensin-converting enzyme with libenzapril in normotensive males. | 1994 Dec |
|
| Absorption of ACE inhibitors from small intestine and colon. | 1994 Sep |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 15:50:16 GMT 2023
by
admin
on
Fri Dec 15 15:50:16 GMT 2023
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| Record UNII |
QD8496WWYK
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| Record Status |
Validated (UNII)
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NCI_THESAURUS |
C247
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ACTIVE MOIETY |
