Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C12H13Cl2N3.BrH |
| Molecular Weight | 351.07 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Br.ClC1=CC=CC(Cl)=C1N(CC=C)C2=NCCN2
InChI
InChIKey=JLFOQBZGELKSOT-UHFFFAOYSA-N
InChI=1S/C12H13Cl2N3.BrH/c1-2-8-17(12-15-6-7-16-12)11-9(13)4-3-5-10(11)14;/h2-5H,1,6-8H2,(H,15,16);1H
| Molecular Formula | BrH |
| Molecular Weight | 80.912 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C12H13Cl2N3 |
| Molecular Weight | 270.158 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Alinidine, a specific bradycardiac agent, which reduces myocardial oxygen consumption and improves exercise tolerance in patients with angina pectoris. In randomized controlled trial alinidine did not enhance myocardial salvage or preservation of left ventricular function of major arrhythmias in the early phase of infarction. The development of this drug was stopped because it was not sufficiently specific for its target.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Alinidine in angina. | 1983 Dec |
|
| Specificity of nonadrenergic imidazoline binding sites in insulin-secreting cells and relation to the block of ATP-sensitive K(+) channels. | 2003 Dec |
|
| Bradycardia induces angiogenesis, increases coronary reserve, and preserves function of the postinfarcted heart. | 2004 Aug 17 |
|
| Antagonism of the insulinotropic action of first generation imidazolines by openers of K(ATP) channels. | 2007 Jan 1 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 10:04:36 GMT 2023
by
admin
on
Sat Dec 16 10:04:36 GMT 2023
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| Record UNII |
Q8XXC72UBI
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| Record Status |
Validated (UNII)
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| Record Version |
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Q8XXC72UBI
Created by
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71306-36-0
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134052
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DTXSID10221461
Created by
admin on Sat Dec 16 10:04:37 GMT 2023 , Edited by admin on Sat Dec 16 10:04:37 GMT 2023
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PARENT -> SALT/SOLVATE |
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ACTIVE MOIETY |