Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C12H13Cl2N3 |
| Molecular Weight | 270.158 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
ClC1=CC=CC(Cl)=C1N(CC=C)C2=NCCN2
InChI
InChIKey=OXTYVEUAQHPPMV-UHFFFAOYSA-N
InChI=1S/C12H13Cl2N3/c1-2-8-17(12-15-6-7-16-12)11-9(13)4-3-5-10(11)14/h2-5H,1,6-8H2,(H,15,16)
| Molecular Formula | C12H13Cl2N3 |
| Molecular Weight | 270.158 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Alinidine, a specific bradycardiac agent, which reduces myocardial oxygen consumption and improves exercise tolerance in patients with angina pectoris. In randomized controlled trial alinidine did not enhance myocardial salvage or preservation of left ventricular function of major arrhythmias in the early phase of infarction. The development of this drug was stopped because it was not sufficiently specific for its target.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Pharmacological stimulation and inhibition of insulin secretion in mouse islets lacking ATP-sensitive K+ channels. | 2010-02-01 |
|
| Selective enhancement of nutrient-induced insulin secretion by ATP-sensitive K+ channel-blocking imidazolines. | 2009-12 |
|
| Heart rate and cardiovascular disease: an alternative to Beta blockers. | 2009 |
|
| Antagonism of the insulinotropic action of first generation imidazolines by openers of K(ATP) channels. | 2007-01-01 |
|
| Molecular regulation and pharmacology of pacemaker channels. | 2007 |
|
| [Selective I(f) channel inhibition: an alternative for treating coronary artery disease?]. | 2006-02 |
|
| Physiology and pharmacology of the cardiac pacemaker ("funny") current. | 2005-07 |
|
| Reduction of heart rate by chronic beta1-adrenoceptor blockade promotes growth of arterioles and preserves coronary perfusion reserve in postinfarcted heart. | 2005-06 |
|
| Angiogenesis in ischaemic and hypertrophic hearts induced by long-term bradycardia. | 2005 |
|
| Bradycardia induces angiogenesis, increases coronary reserve, and preserves function of the postinfarcted heart. | 2004-08-17 |
|
| Specificity of nonadrenergic imidazoline binding sites in insulin-secreting cells and relation to the block of ATP-sensitive K(+) channels. | 2003-12 |
|
| Sinus tachyarrhythmias and the specific bradycardic agents: a marriage made in heaven? | 2003-06 |
|
| Desensitization of insulin secretory response to imidazolines, tolbutamide, and quinine. II. Electrophysiological and fluorimetric studies. | 2001-12-15 |
|
| Desensitization of insulin secretory response to imidazolines, tolbutamide, and quinine. I. Secretory and morphological studies. | 2001-12-15 |
|
| Control of catecholamine-induced tachycardia with alinidine in the anesthetized dog. | 1987-08 |
|
| Alinidine in angina. | 1983-12 |
|
| Effect of alinidine on experimental cardiac arrhythmias. | 1982-03-01 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 18:32:15 GMT 2025
by
admin
on
Mon Mar 31 18:32:15 GMT 2025
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| Record UNII |
E7IDJ8DS1D
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| Record Status |
Validated (UNII)
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| Record Version |
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NCI_THESAURUS |
C29709
Created by
admin on Mon Mar 31 18:32:15 GMT 2025 , Edited by admin on Mon Mar 31 18:32:15 GMT 2025
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| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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C022192
Created by
admin on Mon Mar 31 18:32:15 GMT 2025 , Edited by admin on Mon Mar 31 18:32:15 GMT 2025
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m1508
Created by
admin on Mon Mar 31 18:32:15 GMT 2025 , Edited by admin on Mon Mar 31 18:32:15 GMT 2025
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PRIMARY | Merck Index | ||
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Alinidine
Created by
admin on Mon Mar 31 18:32:15 GMT 2025 , Edited by admin on Mon Mar 31 18:32:15 GMT 2025
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36354
Created by
admin on Mon Mar 31 18:32:15 GMT 2025 , Edited by admin on Mon Mar 31 18:32:15 GMT 2025
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PRIMARY | |||
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CHEMBL278581
Created by
admin on Mon Mar 31 18:32:15 GMT 2025 , Edited by admin on Mon Mar 31 18:32:15 GMT 2025
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PRIMARY | |||
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DTXSID4022571
Created by
admin on Mon Mar 31 18:32:15 GMT 2025 , Edited by admin on Mon Mar 31 18:32:15 GMT 2025
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PRIMARY | |||
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C72571
Created by
admin on Mon Mar 31 18:32:15 GMT 2025 , Edited by admin on Mon Mar 31 18:32:15 GMT 2025
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E7IDJ8DS1D
Created by
admin on Mon Mar 31 18:32:15 GMT 2025 , Edited by admin on Mon Mar 31 18:32:15 GMT 2025
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PRIMARY | |||
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100000087434
Created by
admin on Mon Mar 31 18:32:15 GMT 2025 , Edited by admin on Mon Mar 31 18:32:15 GMT 2025
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SUB05330MIG
Created by
admin on Mon Mar 31 18:32:15 GMT 2025 , Edited by admin on Mon Mar 31 18:32:15 GMT 2025
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33178-86-8
Created by
admin on Mon Mar 31 18:32:15 GMT 2025 , Edited by admin on Mon Mar 31 18:32:15 GMT 2025
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PRIMARY | |||
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4548
Created by
admin on Mon Mar 31 18:32:15 GMT 2025 , Edited by admin on Mon Mar 31 18:32:15 GMT 2025
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PRIMARY |
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SALT/SOLVATE -> PARENT |
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ACTIVE MOIETY |
