HCT-1026

CC(C(=O)OCCCCO[N+]([O-])=O)C1=CC(F)=C(C=C1)C2=CC=CC=C2

InChIKey=DLWSRGHNJVLJAH-UHFFFAOYSA-N

InChI=1S/C19H20FNO5/c1-14(19(22)25-11-5-6-12-26-21(23)24)16-9-10-17(18(20)13-16)15-7-3-2-4-8-15/h2-4,7-10,13-14H,5-6,11-12H2,1H3

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

PubMed

Title	Date	PubMed
Switching the microglial harmful phenotype promotes lifelong restoration of subtantia nigra dopaminergic neurons from inflammatory neurodegeneration in aged mice.	2011-08	21793734
Combining nitric oxide release with anti-inflammatory activity preserves nigrostriatal dopaminergic innervation and prevents motor impairment in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease.	2010-11-23	21092260
Nitroflurbiprofen, a nitric oxide-releasing cyclooxygenase inhibitor, improves cirrhotic portal hypertension in rats.	2007-02	17258737
Nitric oxide-releasing flurbiprofen reduces formation of proinflammatory hydrogen sulfide in lipopolysaccharide-treated rat.	2006-04	16491094
A nitric oxide releasing derivative of flurbiprofen inhibits experimental autoimmune encephalomyelitis.	2004-05	15081244
Inhibition of nuclear factor-kappaB by a nitro-derivative of flurbiprofen: a possible mechanism for antiinflammatory and antiproliferative effect.	2003-04	12716482
Protective effect of NO on gastric lesions and inhibition of expression of gastric inducible NOS by flurbiprofen and its nitro-derivative, nitroflurbiprofen.	1995-09	8528547
Flurbinitroxybutylester: a novel anti-inflammatory drug has enhanced antithrombotic activity.	1995-07-01	7495106

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:11:58 GMT 2025` Edited by `admin` on `Mon Mar 31 18:11:58 GMT 2025`
Record UNII	Q8ERI3E76F
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

HCT-1026

Code

English

FLURBINITROXY BUTYL ESTER

Preferred Name

English

(1,1'-BIPHENYL)-4-ACETIC ACID, 2-FLUORO-.ALPHA.-METHYL-, 4-(NITROOXY)BUTYL ESTER

Systematic Name

English

NO-FLURBIPROFEN

Common Name

English

NITROXYBUTYL FLURBIPROFEN

Common Name

English

Code System Code Type Description

EPA CompTox

DTXSID30936005