CO-101244

Details

Stereochemistry	ACHIRAL
Molecular Formula	C21H27NO3
Molecular Weight	341.444
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=CC=C(CC2(O)CCN(CCOC3=CC=C(O)C=C3)CC2)C=C1

InChI

InChIKey=VKMFDKYCIKEDMR-UHFFFAOYSA-N

InChI=1S/C21H27NO3/c1-17-2-4-18(5-3-17)16-21(24)10-12-22(13-11-21)14-15-25-20-8-6-19(23)7-9-20/h2-9,23-24H,10-16H2,1H3

HIDE SMILES / InChI

Molecular Formula	C21H27NO3
Molecular Weight	341.444
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Glutamate [NMDA] receptor subunit epsilon 2 13 Target ID: CHEMBL311 Sources: https://www.ncbi.nlm.nih.gov/pubmed/12183650	Antagonist 2778		0.043 µM [IC50]
Glutamate NMDA receptor; GRIN1/GRIN2B 6 Target ID: CHEMBL1907603 Sources: https://adisinsight.springer.com/drugs/800011124 \| https://www.ncbi.nlm.nih.gov/pubmed/10425109	Antagonist 2778		5.0 nM [IC50]

PubMed

Title	Date	PubMed
Pharmacological characterization of Ro 63-1908 (1-[2-(4-hydroxy-phenoxy)-ethyl]-4-(4-methyl-benzyl)-piperidin-4-ol), a novel subtype-selective N-methyl-D-aspartate antagonist.	2002 Sep	12183650
Pharmacological modulation of glutamate transmission in a rat model of L-DOPA-induced dyskinesia: effects on motor behavior and striatal nuclear signaling.	2009 Jul	19357321

Patents

Substance Class	Chemical Created by `admin` on `Sat Dec 16 09:23:14 GMT 2023` Edited by `admin` on `Sat Dec 16 09:23:14 GMT 2023`
Record UNII	Q85IYK36S4
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

CO-101244

Common Name

English

4-PIPERIDINOL, 1-(2-(4-HYDROXYPHENOXY)ETHYL)-4-((4-METHYLPHENYL)METHYL)-

Systematic Name

English

PD-174494

Code

English

RO-63-1908

Code

English

1-(2-(4-HYDROXYPHENOXY)ETHYL)-4-((4-METHYLPHENYL)METHYL)-4-PIPERIDINOL

Systematic Name

English

Code System Code Type Description

PUBCHEM

6918409

Created by admin on Sat Dec 16 09:23:14 GMT 2023 , Edited by admin on Sat Dec 16 09:23:14 GMT 2023

PRIMARY

CAS

193359-26-1

Created by admin on Sat Dec 16 09:23:14 GMT 2023 , Edited by admin on Sat Dec 16 09:23:14 GMT 2023

PRIMARY

FDA UNII

Q85IYK36S4

Created by admin on Sat Dec 16 09:23:14 GMT 2023 , Edited by admin on Sat Dec 16 09:23:14 GMT 2023

PRIMARY

Related Record Type Details


					Q85IYK36S4

CO-101244

ACTIVE MOIETY