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Details

Stereochemistry ACHIRAL
Molecular Formula C21H25N
Molecular Weight 291.4299
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MELITRACEN

SMILES

CN(C)CCC=C1C2=CC=CC=C2C(C)(C)C3=CC=CC=C13

InChI

InChIKey=GWWLWDURRGNSRS-UHFFFAOYSA-N
InChI=1S/C21H25N/c1-21(2)19-13-7-5-10-17(19)16(12-9-15-22(3)4)18-11-6-8-14-20(18)21/h5-8,10-14H,9,15H2,1-4H3

HIDE SMILES / InChI

Molecular Formula C21H25N
Molecular Weight 291.4299
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Melitracen (HCl) is a tricyclic antidepressant with actions and effects similar to amitriptyline.Melitracen (HCl) is given orally in the treatment of depression. It should be withdrawn gradually to reduce the risk of withdrawl symptoms. Melitracen (HCl) is primarily indicated in conditions like Anxiety, Asthenia, Depression, gastro-intestinal disorders associated with anxiety and agitation. Melitracen is marketed in Europe and Japan by Lundbeck and Takeda, respectively, for the treatment of depression and anxiety. In addition to single drug preparations, it is also available as Deanxit, a combination product containing both melitracen and flupentixol. The way this drug works hasn’t been thoroughly researched, but some hypothesize that it may work similarly to the drugs Imipramine and Amitriptyline. In comparison to older TCAs, this drug is thought to work more quickly with more favorable side effects.

CNS Activity

Originator

Approval Year

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Deanxit
Primary
Deanxit
Primary
Deanxit

Cmax

ValueDoseCo-administeredAnalytePopulation
9.7926 ng/mL
10 mg single, oral
MELITRACEN plasma
Homo sapiens
10.6205 ng/mL
10 mg single, oral
MELITRACEN plasma
Homo sapiens

AUC

ValueDoseCo-administeredAnalytePopulation
453.7055 ng × h/mL
10 mg single, oral
MELITRACEN plasma
Homo sapiens
477.9061 ng × h/mL
10 mg single, oral
MELITRACEN plasma
Homo sapiens

T1/2

ValueDoseCo-administeredAnalytePopulation
72.793 h
10 mg single, oral
MELITRACEN plasma
Homo sapiens
67.1625 h
10 mg single, oral
MELITRACEN plasma
Homo sapiens

Funbound

ValueDoseCo-administeredAnalytePopulation
11%
MELITRACEN plasma
Homo sapiens

Doses

PubMed

Sample Use Guides

In Vivo Use Guide
Oral Depression Adult: Initially, 25 mg bid-tid, gradually increased to 225 mg daily if necessary. Elderly: Initially, 25 mg daily.
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Record UNII
Q7T0Y1109Z
Record Status Validated (UNII)
Record Version